Hi @Talltreescoldseas

We seem to be going down the same path 😅 i first started on working on

My gut i flew out to Germany to have intensive treatment fmt procedures and the Patricia Kane protocol for detox which is cellular membrane regeneration with glutathione and folic acid for detoxification. I also had heavy metal testing and genetic testing.

Im currently working on my methylation cycle using b2,b6,b9,b12 along with choline. The heavy metal testing is good because if your high in arsenic or lead it’s a sure sign it isnt working correctly. My arsenic was quite high it’s also good to get your homocysteine tested because if it’s above 8-10 it’s another sure sign it’s struggling to work properly. I also have the fast comt variant so I break down neurotransmitters 4x quicker then the average person.

Edited June 6Jun 6 by Richie

On 6/6/2026 at 2:19 AM, Richie said:

Hi @Talltreescoldseas

We seem to be going down the same path 😅 i first started on working on

My gut i flew out to Germany to have intensive treatment fmt procedures and the Patricia Kane protocol for detox which is cellular membrane regeneration with glutathione and folic acid for detoxification. I also had heavy metal testing and genetic testing.

Im currently working on my methylation cycle using b2,b6,b9,b12 along with choline. The heavy metal testing is good because if your high in arsenic or lead it’s a sure sign it isnt working correctly. My arsenic was quite high it’s also good to get your homocysteine tested because if it’s above 8-10 it’s another sure sign it’s struggling to work properly. I also have the fast comt variant so I break down neurotransmitters 4x quicker then the average person.

Good call on the metals

Yeah bro I also have fast comt. Sucks haha my whole life i swear i’ve had like 30% of the dopamine hits of normal people 😂 also very little adrenaline though so super cool during emergencies. Just level.

1 hour ago, Talltreescoldseas said:

Good call on the metals

Yeah bro I also have fast comt. Sucks haha my whole life i swear i’ve had like 30% of the dopamine hits of normal people 😂 also very little adrenaline though so super cool during emergencies. Just level.

Excuse my ignorance but what is "fast comt"? I've never had heavy metals tested, is it worth it? I envy you low adrenaline, I'm always agitated and very reactive 😱

On 6/8/2026 at 10:48 PM, Catbird said:

Excuse my ignorance but what is "fast comt"? I've never had heavy metals tested, is it worth it? I envy you low adrenaline, I'm always agitated and very reactive 😱

No prob. “Comt” here refers to a genetic setting. Basically it’s a gene that has about 4 different common mutations, and they can do either increase or decrease your clearance of neurotransmitters. Similarly to how an ssri slows down your reuptake of serotonin, comt is the base gene that sets your rate of reuptake. It’s like the cruise control setting at 100kmh.

Some peoples are set at 150kmh (mine, fast comt) and some are like 50kmh (slow comt). Basically i get rid of neuros quickly. So adrenaline hits are super fleeting, but its balanced out by reward and other things also being super fleeting.

Heavy metal testing can be good, recommend a hair test for that. But dont worry if they’re a little out. Thats normal. If you have a massive spike in any of them then that’s something to pay attention to

3 hours ago, Talltreescoldseas said:

No prob. “Comt” here refers to a genetic setting. Basically it’s a gene that has about 4 different common mutations, and they can do either increase or decrease your clearance of neurotransmitters. Similarly to how an ssri slows down your reuptake of serotonin, comt is the base gene that sets your rate of reuptake. It’s like the cruise control setting at 100kmh.

Some peoples are set at 150kmh (mine, fast comt) and some are like 50kmh (slow comt). Basically i get rid of neuros quickly. So adrenaline hits are super fleeting, but its balanced out by reward and other things also being super fleeting.

Heavy metal testing can be good, recommend a hair test for that. But dont worry if they’re a little out. Thats normal. If you have a massive spike in any of them then that’s something to pay attention to

Thank you. Food for thought

Been a while so throwing an update on here

Biggest change would be stepping down to 4.5mg of SSRI. Felt shit for a week but then felt much much better.

Bit of brain fog today, 14 days-ish after going down to 4.5.

Found a big group of people who are working with Dr Will Powers to try to find a solution to PSSD (aka PAWS aka shitty long term withdrawal) seems like the clinical abbreviation is PSSD (even though there are many phenotypes of it including of course completely non sexual side effect versions)

He bagan working with PFS and has expanded the scope to include post SSRI damage and harm as well. If anyone wants to check it out look up dr will powers on reddit and search for posts by him in his subreddit. It’s cool to finally see someone tackling this head on that actually greatly cares about the population and believes the accounts of affected individuals.

As for me i’m trucking along still working with gene stuff to figure out what’s going on. Figured out a lot of other stuff that has been personally enlightening to my situation as well and peripherally allowed me to fix some other issues that arent related to the common thread of what we’re all going through.

Cheers to the best

J

Thanks for the update, @Talltreescoldseas Sounds like you’re well on your way to recovery!

3 hours ago, mstimc60 said:

Thanks for the update, @Talltreescoldseas Sounds like you’re well on your way to recovery!

We hope so but aren’t these stupid things fickle as hell, We shall see what the next while brings

Thanks for the update.

I would suggest that you're best off being careful with introducing various new "treatments" at this stage that aim to treat persistent conditions that don't go away long after stopping psychiatric drugs.

This is because you're still taking psychiatric drugs and when you get to lower doses, you feel much better.

I think it's very much worth focusing on looking after yourself and finishing a safe taper and then seeing how you are a while after that.

Hey Luke

That's fair, and that's an opinion that I consider a lot. The other side of the coin is that this started with a different agent to most, as well as being exacerbated by something that doesn't fall into the category of SSRI/SNRI etc.

I also have to stay functional throughout, and when I taper, it's a real crapshoot whether I feel better or not. To me, the adjunct therapies of things can make my situation better. I've been able to return to work, to life, and keep things mostly together after digging myself out of an absolutely awful pit that most of us know all too well. Yes, I am still on psych drugs, but they were part of getting me out of the hole that 5-hpt, my own cellular shit and baseline dna issues, and prednisone got me into. For me, they're a scaffold, or a brace, while I build up the rest of the foundation to support the load that I'm slowly letting rest on it.

I know you don't agree with me, likely won't ever, but I do base my ramblings and musings in research and study. I'm not on here shooting from the hip for conclusions and I do only report things that I have enough basis to suspect or prove.

Most of these things have helped me or I have cast them to the side, and continued on in the name of addressing something that I believe is wrong at baseline with my specific body (as in, why do some of us have horrendous reactions to these meds while others are fine?) Obviously, something is different. And it may be different in different ways, but what I am looking for are things that help out in a general sense.

I would wager millions of dollars, that if you could take the entire population of harmed people, who are harmed in different ways, and analyse the genetics of them all, you would find markers that line up. There is almost no other explanation for why some of us are the way we are and some are different. Thus is the science behind genetics. It's the way we're made.

There are plenty of things that would help greatly. Take it like this: Could I say that restoring perfect mitochondrial function would instantly cure everyone? Of course not. The method of harm is different for different people. Could I say that it would help 100% of people feel at least a little better, and get many people to full recovery? Absolutely.

Take it as you will. This is how I look after myself and perform what I call a safe taper. Others may take some of my information into their own brains and do with it what they will. I'm not a doctor, I'm just really, really, well read.

Doleo, Ergo Sum

Edited August 7Aug 7 by Talltreescoldseas

@Talltreescoldseas Yes, but as you said, everything you're doing is in the context of being harmed by something else and then reacting very positively to psychiatric drugs.

Most of the people on this forum were doing ok until they were very badly harmed by psychiatric drugs.

5 hours ago, Talltreescoldseas said:

There are plenty of things that would help greatly. Take it like this: Could I say that restoring perfect mitochondrial function would instantly cure everyone? Of course not. The method of harm is different for different people. Could I say that it would help 100% of people feel at least a little better, and get many people to full recovery? Absolutely.

How can you say this "absolutely", without absolute proof that psychiatric drug harm always involves disrupted mitochondrial function?

I'm glad you're finding things that you feel are working well for you, but the reality is psychiatric drugs didn't instantly destroy your health- they helped you. I accept that you are really, really, well read when it comes to research papers about mitochondria.

I am really, really well read when it comes to reading thousands of stories of those significantly harmed by psychiatric drugs over a number of years. Obviously this is not scientific, but there are clear trends when it comes to recovery from them that can be observed having done this.

If you do not need this information because psychiatric drugs have been very helpful to you, and your taper is going ok because you're working on fixing the issues you had pre-psychiatric drug, then all I can really say is that your situation is quite different to those harmed by these drugs and I'm glad you're getting better.

Anyway, what I was referring to in my previous post was looking at PSSD and PFS treatments- you do not have these conditions, so very, very early research into how to treat them is something that you might want to evaluate with that in mind.

5 hours ago, Talltreescoldseas said:

I also have to stay functional throughout

Ideally I would also have remained functional instead of disabled and needing full time care for ages, but that's what being harmed and not helped by these drugs looks like.

You can insist that you're really, really well read about things like PSSD and how to recover from it, although you do not have it, and I can listen to you say that with immense skepticism having 90% recovered from PSSD and improving still month to month.

I think CNS harm/sensitivity is the same no matter what pill you take. My hubby is dealing with it having been put on a ridiculously high dose of levothyroxine... people deal with it from antibiotics and birth control.

The fact is everything affects the CNS and the "remedy" remains the same.

You mention staying functional and that is so important but messing around with too much can cause the opposite of that as the 5 htp has proven.

Just my thoughts. ❤️🙏

21 hours ago, Luke said:

Anyway, what I was referring to in my previous post was looking at PSSD and PFS treatments- you do not have these conditions, so very, very early research into how to treat them is something that you might want to evaluate with that in mind.

I dunno man… 5htp is a pretty strong serotogenic substance that I took for many years and is comparable to sertraline in boosting serotogenic signalling. I came iff it and it sent me into a pretty bad tailspin and then prednisone curb stomped me.

21 hours ago, Luke said:

and I can listen to you say that with immense skepticism having 90% recovered from PSSD and improving still month to month.

Nothing makes me happier than seeing your recovery my guy. Everyone’s different, I do know of a lot of people who dont recover from these things with just time. It’s a thing. It’s not necessarily a bad thing to have viewpoints that might work for others. I think that this is just my personal thread that i may be going against the common theme of recovery, yes. But that in itself is just my own lived experience with drug harm. Maybe someone will come along and be looking for stories that measure up to their lived experience and take some of what i say to heart simply because it is different, and it may pertain more to them. We live in a world of infinite variation especially with neuroactive stuff. To not share my viewpoint may be restricting the information that others have where they think “oh man i really don’t think i fit with everyone else because x happened before y in all those cases, but for me it was y then w then x.” It’s all harm.

21 hours ago, Luke said:

How can you say this "absolutely", without absolute proof that psychiatric drug harm always involves disrupted mitochondrial function?

I mean having an immensely important-for-proper-biological-health-in-all-cellular-lifeforms-system that is known to degrade (with no adverse events) purely with age restored to a better functioning system would improve people’s health. even if they were not harmed by any substances at all. It’s degradation is one of the main reasons we actually see the markers for age showing up in tissue tests and etc. Mitochondrial function is probably one of the most solid and reliable tests for determining overall health and biological age for an organism.

2 hours ago, Talltreescoldseas said:

I mean having an immensely important-for-proper-biological-health-in-all-cellular-lifeforms-system that is known to degrade (with no adverse events) purely with age restored to a better functioning system would improve people’s health. even if they were not harmed by any substances at all. It’s degradation is one of the main reasons we actually see the markers for age showing up in tissue tests and etc. Mitochondrial function is probably one of the most solid and reliable tests for determining overall health and biological age for an organism.

I could also say that staying hydrated would improve people's health, but that's not the claim being made here.

You were claiming it would get many people with protracted withdrawal syndrome/persistent psychiatric drug harms to full recovery:

On 8/7/2026 at 3:33 AM, Talltreescoldseas said:

Could I say that it would help 100% of people feel at least a little better, and get many people to full recovery? Absolutely.

6 hours ago, Luke said:

I could also say that staying hydrated would improve people's health, but that's not the claim being made here.

You were claiming it would get many people with protracted withdrawal syndrome/persistent psychiatric drug harms to full recovery:

And you would be right, in a case where taking something results in being dehydrated. Taking SSRIs and other serotogenics does result in the hampering of Mitochondrial processes. This is a proven fact. I can reference a study (and I did link one in my other post)

To address the claim: I’m only stating that it has been proven to be a culprit in many many other neuroaffective disorders, and also a culprit in many withdrawal syndromes that are better studied, such as benzo withdrawal, alcohol withdrawal, opiate withdrawal, etc.

Without actually knowing the method of harm for SSRI PAWS (unless someone does and is keeping it from us) I would draw a logical bridge that at least some of it stems from a disfunction that’s seen extremely widespread in other withdrawal symptoms. If it quacks like a duck, etc.

I would ask you in return: why do you not think it would be helpful?

Edited August 8Aug 8 by Talltreescoldseas

17 hours ago, Talltreescoldseas said:

And you would be right, in a case where taking something results in being dehydrated. Taking SSRIs and other serotogenics does result in the hampering of Mitochondrial processes. This is a proven fact. I can reference a study (and I did link one in my other post)

Yes, but there are also studies showing that psychiatric drugs disrupt an absolutely gigantic range of bodily systems and functions.

So far, nobody has been able to use any of this to consistently push people into a state of recovery.

17 hours ago, Talltreescoldseas said:

Without actually knowing the method of harm for SSRI PAWS (unless someone does and is keeping it from us) I would draw a logical bridge that at least some of it stems from a disfunction that’s seen extremely widespread in other withdrawal symptoms. If it quacks like a duck, etc.

If we don't know the method of harm, and we don't have any kind of consistent pattern of people successfully treating PAWS, can you claim that you have found something that will absolutely put many sufferers into recovery?

17 hours ago, Talltreescoldseas said:

I would ask you in return: why do you not think it would be helpful?

I stated that you cannot absolutely claim that improving mitochondrial function would put many people into full recovery from PAWS. Nobody has successfully demonstrated this yet.

Nothing more, nothing less.