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kangamangus: Struggling with Sertraline and Mirtazapine

Featured Replies

  • Author
5 minutes ago, cherrysquid said:

Me too ❤️

And its Bitsy the mouse from a D&D podcast haha.

Cool-just looked it up. Ive played dnd for like 15 years but had never heard of avantris. Maybe something for me to listen to! Cheers

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

  • Replies 60
  • Views 989
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  • cherrysquid
    cherrysquid

    Stay strong. Bad day for me too. We can do this. It'll pass x

  • kangamangus
    kangamangus

    Sorry to hear that Cherry. We got this. Hang in there

  • SarahMc
    SarahMc

    I definitely empathize with that horrendous combination of exhaustion and activation. I hope you get some sleep tonight 💜.

2 minutes ago, kangamangus said:

Cool-just looked it up. Ive played dnd for like 15 years but had never heard of avantris. Maybe something for me to listen to! Cheers

Urgh im jealous. Ive always wanted to play but none of my friends are into it. I was invited to a gathering a few years ago but I only knew one person and was too shy 😂 ill have to stick to BG3 haha

2016 - Sertraline 50mg

2016 - Sertraline 100mg.

I didnt know better and rarely took it consistently.

June 2024 - went down to 75mg

2025 - Down to 50mg

2026 - down to 25mg

April 2026 - hit by withdrawal and kindling

Reinstated April 2026 - 25mg

May 27th 2026 - Upped to 50mg

  • Author
9 minutes ago, cherrysquid said:

Urgh im jealous. Ive always wanted to play but none of my friends are into it. I was invited to a gathering a few years ago but I only knew one person and was too shy 😂 ill have to stick to BG3 haha

Love bg3. I hope one day you find a good group to play with. Ive been lucky in that regard, same group of friends since high school still play together.

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

  • Author

Really suffering quite badly this morning. About 1 hour of sleep last night. In a total state of panic and flight or fight. Hot flashes and shaking. This is the worst wave ive had. I had a window from Saturday-Monday. Brief window last night of about 2 hours before the shaking started. Just have to keep telling myself that. I will feel better again, its just hard. My body is telling me to hold, so that is what I will do. I need time for this to settle, but god its so hard sometimes. Will never take sleep for granted again.

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

53 minutes ago, kangamangus said:

Really suffering quite badly this morning. About 1 hour of sleep last night. In a total state of panic and flight or fight. Hot flashes and shaking. This is the worst wave ive had. I had a window from Saturday-Monday. Brief window last night of about 2 hours before the shaking started. Just have to keep telling myself that. I will feel better again, its just hard. My body is telling me to hold, so that is what I will do. I need time for this to settle, but god its so hard sometimes. Will never take sleep for granted again.

I’m so sorry @kangamangus, just hang in there. Sometimes we just need to survive a minute at a time. My thoughts are with you today.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author
28 minutes ago, SarahMc said:

I’m so sorry @kangamangus, just hang in there. Sometimes we just need to survive a minute at a time. My thoughts are with you today.

Thanks Sarah, I appreciate that. Surviving a minute at a time is what im doing 🙏

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

1 hour ago, kangamangus said:

Really suffering quite badly this morning. About 1 hour of sleep last night. In a total state of panic and flight or fight. Hot flashes and shaking. This is the worst wave ive had. I had a window from Saturday-Monday. Brief window last night of about 2 hours before the shaking started. Just have to keep telling myself that. I will feel better again, its just hard. My body is telling me to hold, so that is what I will do. I need time for this to settle, but god its so hard sometimes. Will never take sleep for granted again.

Stay strong. Bad day for me too. We can do this. It'll pass x

2016 - Sertraline 50mg

2016 - Sertraline 100mg.

I didnt know better and rarely took it consistently.

June 2024 - went down to 75mg

2025 - Down to 50mg

2026 - down to 25mg

April 2026 - hit by withdrawal and kindling

Reinstated April 2026 - 25mg

May 27th 2026 - Upped to 50mg

  • Author
9 minutes ago, cherrysquid said:

Stay strong. Bad day for me too. We can do this. It'll pass x

Sorry to hear that Cherry. We got this. Hang in there

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

Welcome to the forum.

Hopefully the window of a few days is a sign that you will stabilise in time.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

  • Author

Really struggling. Ive never felt so exhausted in my life, and yet I still feel that "activation". 48hours with 5 hours sleep and rolling panic attacks. Hoping for sleep tonight and a better tomorrow

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

I definitely empathize with that horrendous combination of exhaustion and activation. I hope you get some sleep tonight 💜.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author

I was able to eat a little bit tonight and have calmed down some. My average heart rate yesterday was 100, going up to 130-140 during the panic attacks. Today it was 86 and I didn't have panic attacks as bad as yesterday. Hope this means things are calming down for me. Still feel very sensitized. Thinking now that I never gave my CNS a chance to heal years ago when I initially dealt with withdrawal. Stupid of me, but the pain was too much at the time. I hope one day it can heal and I haven't done permanent damage. Its hard to keep hope that I can heal, but what choice do I have? One foot in front of the other is all I can do. Does anybody have experience with sudden jerking/electric shock sensations when falling asleep? Its like I am so tired and start to doze off then a sudden surge through my body, almost like adrenaline. Wakes me up and I start shaking. Hoping somebody else has dealt with this and has some tips for how to cope and getting sleep.

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

On 7/15/2026 at 4:57 AM, kangamangus said:

Hello, its been a few months since I have posted here. I found I was ruminating too much on withdrawal and had to step back a bit. My taper has been progressing okay, and I am now 25% off of the Sertraline, but unfortunately I am having a hard time now. About a month ago I unknowingly ingested a decent amount of caffeine and had a massive panic attack. This seemed to trigger a horrible wave that I have been stuck in since. I have had windows during that time, but they are fleeting. I have been holding my dose since the panic attack in the hopes that my system would settle down. Yesterday I had a great window followed by another terrible panic attack. Woke up early today and had another panic attack around noon, and I have been stuck in flight-or-fight mode since. I am immensely uncomfortable right now and at a loss for what to do. My rational mind is saying to keep holding at my current dose, but part of me is wondering if I should resume my taper since I was in tolerance withdrawal when I began. I truly don't know what to do. I need to be better about recording my daily thoughts and feelings so I can document the windows when they do happen. I just need to remember that yesterday I was feeling much better than I am right now. I can get back there again. Ugh. Just venting I guess. I will try to update my signature when I am feeling up to it, right now I can barely type this post. Not doing well at all.

On 7/15/2026 at 5:01 AM, kangamangus said:

I forgot to mention, during my first terrible panic attack after the caffeine I took half of a .5mg Klonopin that my mother gave me. It helped in the moment, but I have been wondering if it possibly upset my nervous system even more. I still have the other half of the pill if I really really feel like I need it but I have been able to do without for now. God this anxiety is just unreal.

Hi @kangamangus very sorry for the hot spot you are in.

I feel you well with the unbearable chemical anxiety and understand the dilemma about a possible reduction, I think we are all torn between reducing quickly and waiting and hoping to balance and I wish there was a paved and clear path for all of us but unfortunately there's not.

I think if you managed to balance after waiting long enough in the past it is the right thing to do but of course it is your personal decision.

Regarding Benzo, I understand the desire to lower the flame but it is impossible to put out fire with fire, there is a risk here that is not worth taking.

Please hold on, every difficulty is meant to pass and this too.

Wishing you easier days very soon.

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 21.7% 0.0356.5g (2mg)/15.8 updose by 11.7% 0.0400g (2.23mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of terror, body pain and sleep.

6 hours ago, kangamangus said:

I hope one day it can heal and I haven't done permanent damage.

You won't have, the nerous system is designed to heal, just it isn't fast at it! You are doing great, as others have said the windows are great signs of the body adjusting and healing. More to come. x

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Went to bed earlier last night and managed maybe 4 hours of sleep. Woke up around 4am and kind of dozed in and out until around 7. When I got up, had a bad panic attack. Feeling more settled now and my heart rate has come down. Have a bad headache now and just generally hurt all over. Feel "activated". Like my nervous system has been hooked up to a car battery. Feel like s***. Just very upset by this whole thing. Hoping for a peaceful day. I am not functioning well at all. Spent most of the past 3 days in bed.

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

54 minutes ago, kangamangus said:

Went to bed earlier last night and managed maybe 4 hours of sleep. Woke up around 4am and kind of dozed in and out until around 7. When I got up, had a bad panic attack. Feeling more settled now and my heart rate has come down. Have a bad headache now and just generally hurt all over. Feel "activated". Like my nervous system has been hooked up to a car battery. Feel like s***. Just very upset by this whole thing. Hoping for a peaceful day. I am not functioning well at all. Spent most of the past 3 days in bed.

Hang in there @kangamangus I know its so hard but better times are ahead. Ive seen "activated" mentioned on here a lot. What does it mean?

Are you able to distract yourself with something?

The car battery sensation is awful what helps me with that is a warm bath and I massage bio oil into my stomach and chest where I feel the buzzing sensations.

Hope you feel better soon x

2016 - Sertraline 50mg

2016 - Sertraline 100mg.

I didnt know better and rarely took it consistently.

June 2024 - went down to 75mg

2025 - Down to 50mg

2026 - down to 25mg

April 2026 - hit by withdrawal and kindling

Reinstated April 2026 - 25mg

May 27th 2026 - Upped to 50mg

Just now, cherrysquid said:

Hang in there @kangamangus I know its so hard but better times are ahead. Ive seen "activated" mentioned on here a lot. What does it mean?

Are you able to distract yourself with something?

The car battery sensation is awful what helps me with that is a warm bath and I massage bio oil into my stomach and chest where I feel the buzzing sensations.

Hope you feel better soon x

Oh also a mug of warm milk soothes the buzzing but again I get it in my stomach and chest it might be somewhere else for you

2016 - Sertraline 50mg

2016 - Sertraline 100mg.

I didnt know better and rarely took it consistently.

June 2024 - went down to 75mg

2025 - Down to 50mg

2026 - down to 25mg

April 2026 - hit by withdrawal and kindling

Reinstated April 2026 - 25mg

May 27th 2026 - Upped to 50mg

  • Author

I am considering updosing. I feel so incredibly dizzy and faint. I dont know what to do. I am terrified of going to the hospital. Any advice would be welcome

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

1 hour ago, kangamangus said:

I am considering updosing. I feel so incredibly dizzy and faint. I dont know what to do. I am terrified of going to the hospital. Any advice would be welcome

I'm so sorry for your suffering @kangamangus. I don't know enough about updosing to comment responsibly so I'll leave that to others but I just wanted to say that we're here for you. Do you have anyone around to look after you?

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author
25 minutes ago, SarahMc said:

I'm so sorry for your suffering @kangamangus. I don't know enough about updosing to comment responsibly so I'll leave that to others but I just wanted to say that we're here for you. Do you have anyone around to look after you?

Yes my mother is here. I just feel so strange. Never felt this bad in my life. Im very scared. Dont know how I will get through this. Thank you

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

3 hours ago, kangamangus said:

Yes my mother is here. I just feel so strange. Never felt this bad in my life. Im very scared. Dont know how I will get through this. Thank you

I know it is so, so hard. I think most people on here (including myself) will tell you that WD or drug injury is the worst they've ever felt. And like you, I still have a long taper ahead of me. It is scary, but we can see that so many people ahead of us have gotten through it, so we can too. Keep up the fight.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author

I spoke with a psychiatrist on the phone today. Couldn"t take the activated/akathisia feeling anymore. He is a deprescribing psychiatrist that helps people come off of their meds. He suggested to me that we try propranolol to help in the short term and then resume my taper at a slower pace. I have to get blood work done first which I am going to do tomorrow. Really hoping this helps me cope.

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

17 hours ago, kangamangus said:

Feel "activated". Like my nervous system has been hooked up to a car battery.

15 hours ago, kangamangus said:

I am considering updosing. I feel so incredibly dizzy and faint. I dont know what to do. I am terrified of going to the hospital. Any advice would be welcome

As you feel overly activated I would suggest not updosing personally, it might make you worse. If you do still want to try just around 2.5% max of you current dose so pretty much back to your previous is all I would suggest.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

7 hours ago, kangamangus said:

I spoke with a psychiatrist on the phone today. Couldn"t take the activated/akathisia feeling anymore. He is a deprescribing psychiatrist that helps people come off of their meds. He suggested to me that we try propranolol to help in the short term and then resume my taper at a slower pace. I have to get blood work done first which I am going to do tomorrow. Really hoping this helps me cope.

My thoughts would be to not add any more fuel to fire, but of course this is your choice. I am sorry things are so tough for you atm.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author
19 hours ago, Chippy said:

My thoughts would be to not add any more fuel to fire, but of course this is your choice. I am sorry things are so tough for you atm.

Thanks Chippy. I felt it was necessary as I felt unable to cope. I am not going to updose, I was just in such a desperate state.

Better day today. Just wanted to write that down. Yesterday was the most severe I have ever been. Truly truly horrifying. Felt convinced I had severe brain damage. Still feel that way a little. Lifted just enough at night for me to get 6 hours of sleep.

Woke up today around 7am with intense heart pounding anxiety. Anxiety dissipated and I felt much better than yesterday, I think due to getting some actual restful sleep. If yesterday was an 15/10 on the awful scale today was a 6/10. Even had dreams last night which I havent for a while. Feeling better lasted most of the day, interspersed with some periods of increased anxiety and restlessness. Began to feel bad again once it began to get dark out but it has since settled down. Felt on the verge of a panic attack and told myself if you are going to have one, go ahead and get it over with. Never happened.

I did recieve the prescription for propranolol today. 10mg.I decided to take it. I took half of a pill around 5:30 and felt no discernable difference. Thought I was going to have a panic attack taking it, I was so afraid of triggering something but I didnt. I don't know if it helped or not, if it did the effect was very minor. I took the other half around 8:30. Again no change or very minor calming. Not sure if I will take anymore. Will sleep on it tonight.

Thanks for all of the kind words of encouragement everybody. Tuesday through Thursday this week were awful awful. I appreciate this Site for being somewhere I could reach out to in my desperation.

2008-2017 Sertraline @100mg

2017  Sertraline @50mg 

2017 Mirtazapine @15mg

March 11 Hyperbolic Taper Began

March 11 2026 Sertraline 48.75mg(BM2.5%)

March 18 2026 Sertraline 47.5mg

March 25 2026 Sertraline 46.25mg

April 1 2026 Sertraline 45mg

April 22 2026 Sertraline 43.875mg

April 29 2026 Sertraline 42.75mg

May 6 2026 Sertraline 41.625mg

May 13 2026 Sertraline 40.5mg

June 3 2026 Sertraline 39.5mg

June 10 2026 Sertraline 38.5mg

June 17 2026 Sertraline 37.5mg----Holding here until symptoms stabilize.

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