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Gilda: Urgent support needed: Neurological despair, extreme kindling, and adverse reaction to Mirtazapine

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  • Author

Hi everyone,

I was absolutely terrified of taking any more medications, but I couldn't go on living like that. The visceral anxiety, the strange feeling in my head, the panic attacks, the 24/7 agitation, and everything else you already know about. Remeron (mirtazapine) had completely devastated me. I had only reduced it by 10% and I felt horribly ill for two months, getting worse day by day. Out of sheer desperation, I went to the hospital and was admitted. I was terrified of medications, absolutely frozen with fear. But fortunately, they worked for me and allowed me to completely discontinue Remeron (mirtazapine), which was literally killing me. I still have tinnitus and pain all over my body, especially frequent headaches. I know this is Remeron (mirtazapine) withdrawal, and I hope it passes soon, but it is nothing compared to how I was before. I don't know if reinstating Rivotril (clonazepam) was a good idea, but anyway, I am now back to cooking, cleaning the house, and grocery shopping without having panic attacks. I even managed to sit at the PC and make payments that I had been dragging out for two months. Let's say I'm at 50%.

The psychiatrist I was assigned to after the hospital discharge understood my extreme sensitivity to medications, and especially to withdrawals. For the time being, I am going to stay like this for a while. Reducing Levopraid (levosulpiride) was not a good idea. In fact, my psychiatrist told me to stop the reduction or, at most, just increase it by one single drop without going back to the original dosage. It really seems like she understands how tapering works. I am able to sleep, but the problem is that I have nightmares about the medications that harmed me; I feel emotionally blocked in this condition. On a positive note, I even visited a website where I used to buy clothes, which was unthinkable for me before. Tonight I am going out with my friends, something I couldn't even bear to think about doing until recently. I was lucky to find a therapy that helped me.

Thank you so much for the support you have given me. I will keep you updated.

Medication History

  • January – March 2025: Use of Xanax (Alprazolam).

  • Late March 2025: Mirtazapine 15 mg for only two weeks.

  • May 2025 – December 2025: Use of Rivotril (Clonazepam) (8 drops in the evening, 5 drops in the morning).

  • December 1, 2025: Discontinuation of Rivotril (Clonazepam) after a 4-month taper. Experienced various physical pains but no depression or agitation. Developed tinnitus. Since then: chronic agitation, vertigo, diagnosed by psychiatrists as "automated anxiety," and persistent tinnitus.

The Final Breakdown (February 2026)

After discontinuing Rivotril (Clonazepam), I suffered trauma from "polypharmacy," triggering a violent reaction:

  • February 6–16: Rapid rotation between medications (Mirtazapine, Olanzapine, Zoloft, Cipralex).

  • February 17: I decided NOT to take the dose because the tinnitus had become unbearable.

  • February 17 – March 22: Total discontinuation. The abyss: subjective akathisia, debilitating panic attacks, constant chest tightness.

Chaos and harm caused by dosage variations in March:

  • March 22–23: Reintroduction of Mirtazapine 7.5 mg. Subjective akathisia improved, but severe chest pain appeared.

  • March 24–27: Dosage reduced to 3.5 mg. Reintroduction of Rivotril (Clonazepam) (1 drop on March 26 and 27). It was after this reduction that physical pain, immediate and violent, exploded.

  • March 28: I discontinued Rivotril (Clonazepam) and returned to Mirtazapine 7.5 mg. I felt extremely ill for a week with a "strange head" and pain. Then, slowly, I stabilized slightly. Tinnitus decreased. I have good days, but I still have a lot of agitation.

Recent events:

  • April 18: Reduced Mirtazapine to 5 mg, but was forced to return to 7.5 mg the following day. Since then: strange sensation in the head, back pain, violent tinnitus.

  • April 25: Reduced to 6.8 mg of Mirtazapine. Worse than before: severe back pain, depression, insomnia, stomach pain, muffled ears, tinnitus in the head. Increased agitation, visceral akathisia appearing throughout the day, headache.

  • Currently, April 29: Reduced Mirtazapine dosage to 6.8 mg

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  • mstimc60
    mstimc60

    I feel you, @Gilda I had to work through my withdrawal because my job carried my family's insurance. It was tough but I made it. Some days I couldn't do much more than listen to a calming audio over a

  • Emsy
    Emsy

    Hi @Gilda sorry to be replying so late, I only check in occasionally at the moment as I find I get very triggered reading others threads and so I’ve just picked up my tags. I use the oradispersible ta

  • Chippy
    Chippy

    Hey @Gilda yes many of us on here have had our lives turned upside down by this nasty drug. I am sorry you are having to deal with it too. This is too common a story, you are not alone Gilda. I am v

20 minutes ago, Gilda said:

Hi everyone,

I was absolutely terrified of taking any more medications, but I couldn't go on living like that. The visceral anxiety, the strange feeling in my head, the panic attacks, the 24/7 agitation, and everything else you already know about. Remeron (mirtazapine) had completely devastated me. I had only reduced it by 10% and I felt horribly ill for two months, getting worse day by day. Out of sheer desperation, I went to the hospital and was admitted. I was terrified of medications, absolutely frozen with fear. But fortunately, they worked for me and allowed me to completely discontinue Remeron (mirtazapine), which was literally killing me. I still have tinnitus and pain all over my body, especially frequent headaches. I know this is Remeron (mirtazapine) withdrawal, and I hope it passes soon, but it is nothing compared to how I was before. I don't know if reinstating Rivotril (clonazepam) was a good idea, but anyway, I am now back to cooking, cleaning the house, and grocery shopping without having panic attacks. I even managed to sit at the PC and make payments that I had been dragging out for two months. Let's say I'm at 50%.

The psychiatrist I was assigned to after the hospital discharge understood my extreme sensitivity to medications, and especially to withdrawals. For the time being, I am going to stay like this for a while. Reducing Levopraid (levosulpiride) was not a good idea. In fact, my psychiatrist told me to stop the reduction or, at most, just increase it by one single drop without going back to the original dosage. It really seems like she understands how tapering works. I am able to sleep, but the problem is that I have nightmares about the medications that harmed me; I feel emotionally blocked in this condition. On a positive note, I even visited a website where I used to buy clothes, which was unthinkable for me before. Tonight I am going out with my friends, something I couldn't even bear to think about doing until recently. I was lucky to find a therapy that helped me.

Thank you so much for the support you have given me. I will keep you updated.

@Gilda I'm so happy for you. It must feel wonderful to have some relief and get back to life. I'm literally trapped by my meds. The slightest change and all hell breaks loose. The last 2 months of my journey have been a nightmare. So much physical pain and sheer terror. The ADs have generally locked my mood into a nothing position - no joy, no depression. However now I have a deep sense of foreboding, feeling I'll be stuck here forever.

I'll be interested to see how you progress over the next few months. Being on multiple medications just seems to complicate things for me. 🤗

Link to SA Profile: https://www.survivingantidepressants.org/forums/topic/32414-catbird-introduction-a-long-and-winding-road/

1996 Commenced on Sertraline 50 - 100mg. Many ADs trialled -Fluoxetine 20 mg, Paroxetine 20mg, Venlafaxine 75mg, Escitalopram 10 - 20mg, Vortioxetine 20mg, Bupropion 150mg.  2019 Recommenced Escitalopram 2022 Mirtazapine 30mg - Rapid taper. Amitriptyline 20mg

CURRENT MEDICATIONS: Escitalopram taper from ~ 10mg commenced 2024, Amitriptyline 20mg at night, Diazepam 7.5mg total per day, Baclofen 10mg morning, 10mg lunch and 20mg night, Polaramine 2mg at night, Ketamine troche 25mg per day (Ceased early September 2025), Valsartan 160mg evening, HRT (Oestrogen 25mcg/day) 

ESCITALOPRAM TAPER: 5 April 2025 - started holding at 1.516mg. Escitalopram taper resumed July 2025; End Aug 1.364; End Sept 1.228; End Oct 1.145; End Nov 1.1 Early Dec 1.11; End Dec 1.082; 2026 End Jan 1.047; Feb 6 1.030; Feb 20 1.014; April 10 1.012; May 3 1.014; May 11 1.020 & still holding; Sept 19 1.014; Oct 4 1.006; Oct 8 1.010

Supplements: Mg++ glycinate, Omega 3s, Curcumin. Vit D3/K2 spray, Vitamin B12 spray, chelated zinc.

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