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Dee86: SNRI stopped and SSRI introduced, system overwhelmed.

Featured Replies

  • Author

Hi @SarahMc i did, I did two weeks on 175 and currently day 3 on 150. Feeling really crappy though 😭

SNRI for 14 years, GP stopped cold turkey. Introduced/removed 4 other meds in 5 months

2 hours ago, Dee86 said:

Hi @SarahMc i did, I did two weeks on 175 and currently day 3 on 150. Feeling really crappy though 😭

I’m sorry 😞. If it helps, it’s not surprising that you’re still feeling bad. You’re not an outlier or anything. And you can get better.

Is your plan to stay on the 150 Zoloft and try to stabilize? Or are you going to come off altogether?

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author

Thanks @SarahMc

I think I’m going to stay on 150 for a bit before anymore changes, I want to get off this eventually. I feel like my brain is fried, there has been that many medication changes in 6 months, I’m trying to feel a little more normal before anymore before anymore changes 😭

SNRI for 14 years, GP stopped cold turkey. Introduced/removed 4 other meds in 5 months

8 hours ago, Dee86 said:

I’m trying to feel a little more normal before anymore before anymore changes 😭

I think that is a really good idea. How would you rate your symptoms out of 10 before and after reducing? 10 being the worse you could imagine?

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Hey @Chippy I felt ok towards the end of the two weeks on 175.

The last few days on 150 have been a little harder, exhausted, headaches, severe brain fog, really down. I can’t even tell if this is the medication decrease or something else 😩

SNRI for 14 years, GP stopped cold turkey. Introduced/removed 4 other meds in 5 months

4 minutes ago, Dee86 said:

@ I felt ok towards the end of the two weeks on 175.

That is good news.

4 minutes ago, Dee86 said:

The last few days on 150 have been a little harder, exhausted, headaches, severe brain fog, really down.

Can you put a number on it?

4 minutes ago, Dee86 said:

I can’t even tell if this is the medication decrease or something else 😩

Oh it will be the cut, Im sure!

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

2 hours ago, Dee86 said:

The last few days on 150 have been a little harder, exhausted, headaches, severe brain fog, really down. I can’t even tell if this is the medication decrease or something else 😩

I have all of these symptoms @Dee86! It’s definitely all the med changes. I’m now about 3.5 months into my hold and still not great, but doing better overall. It takes a lot of patience, but if you stop making changes you can likely stabilize over time before starting your taper.

As Chippy said, it would be helpful to get a better idea of how bad your symptoms are — can you rate them out of 10, 10 being the worst?

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

On 6/14/2026 at 5:02 PM, Dee86 said:

Doctor said he doesn’t recommend reinstating the SNRI since it’s been almost 5 months. He did however tell me to drop the Zoloft to 150mg from the 200mg. I’m just scared 😭

Hi @Dee86 I'm so sorry you feel scared although it's legitimate to feel that way in this very, very challenging process.

Can I ask what symptoms you're experiencing? Is it constant or are there also lighter moments?

Also, could you please elaborate on what you were on and at what dosage you stopped?

I'll just add that no matter how bad you feel now, it's temporary, there will be unbearable moments, but the body is making tremendous efforts to heal and this is reflected in what it's experiencing.

Hang in there, we're with you.

Edited by Fullhealing

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 21.7% 0.0356.5g (2mg)/15.8 updose by 11.7% 0.0400g (2.23mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of terror, body pain and sleep.

  • Author

Hi all,

@Chippy @SarahMc thanks for both your replies. On a scale of 1-10 I would say a 5. Definitely better than a couple of months ago, I’m back at work part time. Since the decrease to 150mg (on day 4 now) it’s just been a struggle to focus, constant pit in my stomach and very sad. I did have the same feelings at 200mg and when dropping to 175mg but not as bad.

@Fullhealing thank you for your reply. Above is what I’m feeling.

I’m sorry I need to update my signature to include my meds. Below are the meds and changes this all happened after a breakdown in January 😢

Pristiq 100mg 14 years - stopped cold turkey in January 2026.

Mirtazapine 15mg added on for 15 days, increased to 30mg for 25 days then stopped.

Zoloft 50mg added for 20 days

Zoloft increase to 100mg for 7 days

Risperidone 1mg added when Zoloft increased. After 12 days this was stopped.

Zoloft increase to 150mg for 7 days.

Zoloft increased to 200mg - on for 13 weeks

Quetiapine 25mg added during the Zoloft increase and stopped after 36 days.

Two weeks ago

Zoloft dropped to 175mg for two weeks

Zoloft now at 150mg day 4

Hope this sheds some light ❤️

SNRI for 14 years, GP stopped cold turkey. Introduced/removed 4 other meds in 5 months

  • Author

Just came back from my doctor, he thinks it’s depression returning. He has no idea 😭

SNRI for 14 years, GP stopped cold turkey. Introduced/removed 4 other meds in 5 months

6 hours ago, Dee86 said:

Hi all,

@Chippy @SarahMc thanks for both your replies. On a scale of 1-10 I would say a 5. Definitely better than a couple of months ago, I’m back at work part time. Since the decrease to 150mg (on day 4 now) it’s just been a struggle to focus, constant pit in my stomach and very sad. I did have the same feelings at 200mg and when dropping to 175mg but not as bad.

@Fullhealing thank you for your reply. Above is what I’m feeling.

I’m sorry I need to update my signature to include my meds. Below are the meds and changes this all happened after a breakdown in January 😢

Pristiq 100mg 14 years - stopped cold turkey in January 2026.

Mirtazapine 15mg added on for 15 days, increased to 30mg for 25 days then stopped.

Zoloft 50mg added for 20 days

Zoloft increase to 100mg for 7 days

Risperidone 1mg added when Zoloft increased. After 12 days this was stopped.

Zoloft increase to 150mg for 7 days.

Zoloft increased to 200mg - on for 13 weeks

Quetiapine 25mg added during the Zoloft increase and stopped after 36 days.

Two weeks ago

Zoloft dropped to 175mg for two weeks

Zoloft now at 150mg day 4

Hope this sheds some light ❤️

Thank you for detailing @Dee86 I'm sorry, just see now that I didn't address your last update, anyway given the chemical mix, the CT and the fresh changes with Zoloft it is more than likely that you will feel the way you do but I see that you have managed to return to work part time which is amazing, I hope this will distract you somewhat, for many of us in the acute stages work is simply impossible so be very proud of yourself.

Hang in there, it's a tough ride but you got it!

Wishing you blessed long relief very soon 🩷

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 21.7% 0.0356.5g (2mg)/15.8 updose by 11.7% 0.0400g (2.23mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of terror, body pain and sleep.

9 hours ago, Dee86 said:

On a scale of 1-10 I would say a 5. Definitely better than a couple of months ago, I’m back at work part time. Since the decrease to 150mg (on day 4 now) it’s just been a struggle to focus, constant pit in my stomach and very sad. I did have the same feelings at 200mg and when dropping to 175mg but not as bad.

Good to hear things are better, how would you rate just before the cut and now after the cut?

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

@Chippy towards the end of the two weeks maybe 4 not that much better than I’m feeling now, but I had more windows of being ok, the past 3 days have been a constant ugliness, crying, pit in my stomach, head aches/tension.

I don’t even know what’s normal whilst going through this, I’m just hoping its temporary with the recent decrease.

SNRI for 14 years, GP stopped cold turkey. Introduced/removed 4 other meds in 5 months

19 hours ago, Dee86 said:

@Chippy towards the end of the two weeks maybe 4 not that much better than I’m feeling now, but I had more windows of being ok, the past 3 days have been a constant ugliness, crying, pit in my stomach, head aches/tension.

I don’t even know what’s normal whilst going through this, I’m just hoping its temporary with the recent decrease.

Ok, so things improved for you close to the point you cut, now you have cut things haven't worsened just you are not getting any breathers/windows? that sounds ok, I would just hold and monitor how you go, once you start to improve a little you can see where you want to go next. If things settle quickly you could perhaps make a further bigger cut, if it takes some time perhaps a smaller reduction is needed. I think it would be worth considering letting this get more in the 'mild' catogery before making any more reductions. Finding that normal baseline takes a little time but you'll sus it.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

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