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Steve1: Escitalopram nightmare - please help

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  • Author

Concerned its got worse every day since Sunday.

Will the body ever stabilise?!

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

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  • Bernadette
    Bernadette

    Hi @Steve1 a just read through your thread and from what I have read you say you went from 10mg to 5mg of escitalopram. So back when I was tappering citalopram which is the older of the two , escital

  • I have a thread in the success stories that I think tells the tale. Long story short, I'd been on Bupropion(wellbutrin) for 20 years, and I later read that if you're on a med for that long and begin

  • LostinCanada
    LostinCanada

    Hi @Steve1 I had a quick read of your thread. I suggest that you reread it as well. I really heard you saying escitalopram never has been good from the start. IMO you would not want to increase due to

3 hours ago, Steve1 said:

Concerned its got worse every day since Sunday.

Will the body ever stabilise?!

Waves and windows @Steve1. For myself, I've found it much more useful to look at my progress over months rather than days or weeks. You'll get there 🫂

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

@Steve1 Hello mate I wish you a speedy and full recovery as soon as possible. May god be on your side.

Is your activation permanent? Or does it come and go? I seriously consider to make an updose because from all the way down from 100mg to the current 6,52mg I never experienced such bad symptoms. It is very very clearly withdrawal for me so updosing might help. But I also get activation. But not persistent, it settles down after 20-30 minutes.

March 2020 Lexapro 10mg | August 2020 Lexapro 5mg (-50%), then stopped abruptly; mild akathisia and aggression for about one week.
January 2021 Zoloft 100mg | May 2022 75mg (-25%) | September 2022 50mg (-33.3%) | March 2023 25mg (-50%); libido disappeared and genital sensitivity decreased sharply.
July 2024 began tapering liquid Zoloft from 25mg | August 2024 22.5mg (-10%; held an extra month due to feeling unwell) | September 2024 19mg (-15.6%) | November 2024 17mg (-10.5%).
June 2025 Zoloft 9mg | September 2025 6.8mg; remained at 6.8mg for several months.
28 July 2026 Zoloft 6.80mg; daily reductions: 6.79 → 6.77 → 6.75 → 6.73 → 6.71 → 6.69 → 6.68mg; held for about two weeks because of activation and sleep problems.
August 2026 resumed daily reductions: 6.66 → 6.64 → 6.62 → 6.60 → 6.58 → 6.56 → 6.54 → 6.52mg (-4.1% from 6.80mg); holding at 6.52mg since 23 August 2026. | September 2026; Increased dose to 6,6mg to stabilize.

  • Author

Hi @leminaseri I can't be sure if its withdrawal or ongoing activation from escitalopram as the predominant side effect at the moment.

As a result I am trying to hold the line at 5mg and hoping the body can stabilise at some stage.

I really don't want to up dose ideally as 10mg was horrific

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

21 hours ago, Steve1 said:

Concerned its got worse every day since Sunday.

Will the body ever stabilise?!

Sorry Steve you really can't tell if you will stablise over such a short period of time. Worsening isn't un common, waves come, they also go. If you choose to continue holding you need to accept the ride mate. The body needs an unreasonable amount of time to settle from changes often.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

I felt okayish 5/10 for a few hours yesterday evening. But struggled to get to sleep and woken up feeling bad

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

Just now, Steve1 said:

I felt okayish 5/10 for a few hours yesterday evening. But struggled to get to sleep and woken up feeling bad

Take the win mate, it is a great sign. Sleep gets really messed up in WD unfortunately. Im sorry you feel bad today, lack of sleep is awful.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Hopefully I'm approaching the peak soon

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

1 minute ago, Steve1 said:

Hopefully I'm approaching the peak soon

I have everything crossed you have some better days very soon mate.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Thank you.....still holding out at 5mg. 7 weeks today

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

  • Author

Still feel dreadful. Will this misery ever end?

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

2 hours ago, Steve1 said:

Still feel dreadful. Will this misery ever end?

I'm so sorry, Steve, but rest assured this will end.

Right now, being at the bottom of the graph you see nothing but eternal suffering, yet just a little further ahead you will be at the very top where the present moment will look like a distant nightmare..

Just hold onto hope and keep surviving with distractions alongside acceptance as much as possible, you're system is constantly healing and will recover.

Easier days will come.

Sending lots of strength.

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 21.7% 0.0356.5g (2mg)/15.8 updose by 11.7% 0.0400g (2.23mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of terror, body pain and sleep.

  • Author

Dr says that withdrawal will only last a maximum of 8 weeks. Is this a reasonable timeframe or is he misguided?

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

22 minutes ago, Steve1 said:

Dr says that withdrawal will only last a maximum of 8 weeks. Is this a reasonable timeframe or is he misguided?

Unfortunately it can last longer, as all the folk on this forum will attest. Unless you want to believe that this doctor is correct, and everyone here finished withdrawal after 8 weeks, and then we all happened to develop new and mysterious illnesses that continued after that time.

We simply don't know how long your symptoms will last. I had a patient recently who was severely ill with WD for 3 months (bedbound and off work), then she recovered quite quickly and is fine now at 6 months off. Then you have folk here like Luke, who is still far from recovered at 3.5 years off, although improving.

All you can do is seek as much support as necessary and try to hang in there. Sending you care Xx.

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

  • Author

Feels like I can't win....10mg was too activating and now feel like I'm in deep withdrawal from 5mg (7weeks)!

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

1 hour ago, Steve1 said:

Dr says that withdrawal will only last a maximum of 8 weeks. Is this a reasonable timeframe or is he misguided?

Not necessarily misguided, for some it can happen within that time frame and for others it takes much longer.

Honestly, I wouldn't set a timeline even though I know how difficult the uncertainty is, our mind simply hates it, however, if you set a specific point in time and your expectations aren't met, it can be pretty devastating.

Try to focus on the present moment and not look further ahead than today, symptoms will come and go with varying intensities and when the system finishes regulating it will be over, that's a guarantee, but when exactly.. no one knows.

I hope those harsh days will be over soon for you, hang in there.

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 21.7% 0.0356.5g (2mg)/15.8 updose by 11.7% 0.0400g (2.23mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of terror, body pain and sleep.

  • Author

Thank you....today has been brutal

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

17 hours ago, Steve1 said:

Dr says that withdrawal will only last a maximum of 8 weeks. Is this a reasonable timeframe or is he misguided?

They are just old school and out of date. It is well understood now that WD and WD injury can last much much longer than 8 weeks. Continuing to believe and inform patients in 2026 in the UK where we have changes to guidelines and access to new data in the form of the Maudlsey Deprescribing Guidelines is un acceptable imo. Unfortunately very common still.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

So confused what to do with my dose. Now 7 weeks 2 days at 5mg and feel dreadful

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

8 minutes ago, Steve1 said:

So confused what to do with my dose. Now 7 weeks 2 days at 5mg and feel dreadful

Here for you what ever you choose to do Steve.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Really worried I've done permanant damage to my body

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

Hello @Steve1 I've had the Escitalopram WD experience also, so I understand what you're going through. It can be a dark and scary place – I get that!

It could be likened to a prison sentence! Not sure where you are in the world, but in the UK in the 70s we had a famous TV comedy sitcom called Porridge. The lead character was always giving good advice to his young cellmate about enduring: 'keeping your head down'; 'don't let the nerks grind you down', and simply 'doing your 'Porridge' (sentence). Acceptance I guess, being the point. I often called this to mind as my own Escitalopram Porridge ticked on…

Of practical help I found that in those darkest moments, turning the focus of my mind away from what I couldn't control (the random WD symptoms which you just cannot predict) to something that was within my control helped me endure.

Either a small 'mindless' task, say like making your bed; vacuuming; washing-up, (I know that can be challenging also!) Or, for me learning to control my reaction to the cascade of symptoms through breathing.

Google 'Box Breathing', and tips for calming the Vagus nerve – like pinching the ear lobes! Sounds whacky – but works!

Learning to modify our anxiety responses when we can't actually change circumstances and facts, has helped me. All the best.

1988 (Age 24) Prozac – briefly, then ceased.

1990 – 2007 Citalopram 20mg, then 10mg. Several 6-month cold-turkey/hard-stops, then reinstatements.

2007 Venlafaxine briefly, then ceased.

2008 – 2010 Citalopram 10mg

2010 Wellbutrin (Buproprione XL) 150mg + Citalopram 10mg

2010 – 2018 Alternated either/or Wellbutrin (Buproprione XL)/Citalopram annually.

2019 – 2021 Switched Citalopram with Escitalopram (Lexapro) 10mg

Sept 2021 Started Wellbutrin (Buproprione XL) 3 month taper (50%), skipping days.

Dec 2021 Wellbutrin (Buproprione XL) ceased.

Feb 2022 Started Escitalopram (Lexapro) 3 month taper (50%), skipping days.

May 2022 Escitalopram (Lexapro) ceased.

  • Author

Its so bizarre....I go from thinking its withdrawal to then thinking its ongoing activation from the 5mg pill

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

Just now, Steve1 said:

Its so bizarre....I go from thinking its withdrawal to then thinking its ongoing activation from the 5mg pill

You can't really know for sure. Aiming for replacing thinking – with doing (like the controlled breathing) helped me greatly.

1988 (Age 24) Prozac – briefly, then ceased.

1990 – 2007 Citalopram 20mg, then 10mg. Several 6-month cold-turkey/hard-stops, then reinstatements.

2007 Venlafaxine briefly, then ceased.

2008 – 2010 Citalopram 10mg

2010 Wellbutrin (Buproprione XL) 150mg + Citalopram 10mg

2010 – 2018 Alternated either/or Wellbutrin (Buproprione XL)/Citalopram annually.

2019 – 2021 Switched Citalopram with Escitalopram (Lexapro) 10mg

Sept 2021 Started Wellbutrin (Buproprione XL) 3 month taper (50%), skipping days.

Dec 2021 Wellbutrin (Buproprione XL) ceased.

Feb 2022 Started Escitalopram (Lexapro) 3 month taper (50%), skipping days.

May 2022 Escitalopram (Lexapro) ceased.

  • Author

Not sure I can recover from this

2014- April 2025 Escitalopram 10mg

April 2025 - straight swap to Sertraline 50mg

Dec 2025-Jan 2026 - tapered off Sertraline 50mg - 0mg

Jun 2026 - Escitalopram 10mg 9 weeks

Aug - Escitalopram 5mg

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