Tulip: Imipramine

March 17Mar 17

Author

I guess I should take the Ativan like usual. I am so unmotivated, flat feeling with waves of sadness today..I just can’t function.

Also, to get 14mg of imipramine ive been swallowing 1 10mg tablet then dissolving a 10mg imipramine tablet in 20ml of water, mixing it well, syringing out 4mg and squirting that in my mouth.. drinking it down with water. There’s really no way of knowing how much medication I’m getting in this liquid.

Edited March 17Mar 17 by Tulip

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

March 17Mar 17

25 minutes ago, Tulip said:

I guess I should take the Ativan like usual. I am so unmotivated, flat feeling with waves of sadness today..I just can’t function.

Also, to get 14mg of imipramine ive been swallowing 1 10mg tablet then dissolving a 10mg imipramine tablet in 20ml of water, mixing it well, syringing out 4mg and squirting that in my mouth.. drinking it down with water. There’s really no way of knowing how much medication I’m getting in this liquid.

how long have you been taking ativan ? a few days or months ?

if a few days please stop the ativan to avoid having another dependency.

if you took ativan for months, you will need to be tapering it properly in due time.

please look up about how to make a proper liquid, im not sure if this drug stays mixed in the water for a bit after shaking it.

it's your life, you got to taper it properly.

if you are so badly down due to impramine withdrawal, you might be wanting to just try updosing back to 20mg, untill you learn how to properly tapering this drug, your current regime makes no sense and you are just causing your nervous system more chaos.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.
Feel free to mention me whenever help is needed.

Current Supplements: Morning: Aloe Vera Gels. Night: 6mg melatonin and 133mg magnesium glycinate. Taking Omega 3 as needed to calm dyskinesia or over stimulation..

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

March 17Mar 17

55 minutes ago, Tulip said:

I guess I should take the Ativan like usual. I am so unmotivated, flat feeling with waves of sadness today..I just can’t function.

Also, to get 14mg of imipramine ive been swallowing 1 10mg tablet then dissolving a 10mg imipramine tablet in 20ml of water, mixing it well, syringing out 4mg and squirting that in my mouth.. drinking it down with water. There’s really no way of knowing how much medication I’m getting in this liquid.

Hi @Tulip I went through your thread a bit and I'm wondering why your last cuts were relatively large? the lower doses are harder and this is where it's better to be more careful, and btw, benzo's (Ativan) can definitely cause a lack of motivation and a general feeling of being shut down. It turns off anxiety but also everything else.

Edited March 17Mar 17 by Fullhealing

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 21.7% 0.0356.5g (2mg)/15.8 updose by 11.7% 0.0400g (2.23mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of terror, body pain and sleep.

March 17Mar 17

Author

Ok, I came from SA and this is the way to properly dissolve the tablet.. I was only saying that there’s no real way of knowing what you get but I’ve done it this way for years.

My reason for such a big cut is explained in detail in this thread.

@getofflexare you here? Any others from SA here?

Edited March 17Mar 17 by Tulip

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

March 18Mar 18

9 hours ago, Tulip said:

I guess I should take the Ativan like usual. I am so unmotivated, flat feeling with waves of sadness today..I just can’t function.

Yes if you’ve been taking it regularly you should now. If you can feel stable and feel the Ativan is causing you to feel flat you could start to reduce it. As you’ve not been on it long you can come off quicker. I’m lost if I’m honest with how much you take and when. Start by establishing a base line regular dose of everything for 14 days and let’s go from there.

Can you confirm what that will be and write it in your signature?

9 hours ago, Tulip said:

Also, to get 14mg of imipramine ive been swallowing 1 10mg tablet then dissolving a 10mg imipramine tablet in 20ml of water, mixing it well, syringing out 4mg and squirting that in my mouth.. drinking it down with water. There’s really no way of knowing how much medication I’m getting in this liquid.

This is all fine. It’s totally normal to make your own diy liquid up.

ill leave this here just for you to confirm what youre doing is correct. But it all looks fine to me from what you have said. Consistency is the main thing so you get the same drug amount each day.

Preparing Doses for Tapering - Weighing & DIY Liquids

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

March 20Mar 20

Author

Last night I fell asleep watching tv so didn’t I take the imipramine and I finally slept five solid hours. This is the first time in weeks that I didn’t wake up every 1 1/2-2 hours. I didn’t skip it just took it early in the a.m. just wanted to log and keep notes.

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

March 20Mar 20

2 hours ago, Tulip said:

Last night I fell asleep watching tv so didn’t I take the imipramine and I finally slept five solid hours. This is the first time in weeks that I didn’t wake up every 1 1/2-2 hours. I didn’t skip it just took it early in the a.m. just wanted to log and keep notes.

Be careful @Tulip try to take your dose the same time each night. It’s important your brain gets consistent doses.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

March 21Mar 21

Author

I have to take my restless legs med (mirapex) an hour or two before I take my imioramine bc the imioramine makes my restless legs crazy. Last night I took the mirapex as usual and 30 minutes later my restless legs was actually worse then it had been in a while. I had to get up and walk around and distract myself for about thirty minutes before my legs calmed down. I have been having a string suspicion for a couple of years now that the imioramine is prob causing my restless legs. I’m curious as to why my rls is going crazy all of a sudden after take the medication to stop it all of a sudden. Maybe bc of my lowering the imipramine dose? Maybe I don’t need the mirapex anymore?

Edited March 21Mar 21 by Tulip

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

March 22Mar 22

4 hours ago, Tulip said:

Maybe I don’t need the mirapex anymore?

If you don’t want to be on it. It also needs tapering. I’d still hold everything and wait to settle. When things have a bit you can perhaps start to taper this first and see how you react. If you can get in a good rhythm with that taper you could add the other in at the same time and see if you can tolerate it.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

March 23Mar 23

Author

My grandmother takes a lower dose of maripex and I got 5 from her to try. Symptoms are much better

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

March 24Mar 24

6 hours ago, Tulip said:

My grandmother takes a lower dose of maripex and I got 5 from her to try. Symptoms are much better

What dose were you on before? It’s not clear from your signature. Make sure you update it. As I said before you are supposed to taper it rather than chop your dose around. I’m glad it’s much better though.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

March 31Mar 31

Author

I was on 75 mirapex and I tapered to .5 a little over a week.

Withdrawals from imipramine taper and Mirapex taper has settled down.. doing much better.

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

1

March 31Mar 31

1 hour ago, Tulip said:

I was on 75 mirapex and I tapered to .5 a little over a week.

Withdrawals from imipramine taper and Mirapex taper has settled down.. doing much better.

Glad things are easier for you 😀

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

April 1Apr 1

Author

A little over a year ago my eyes were hurting and feeling strained so I made an appt with eye doc. He said you’re having these headaches bc your prescription is too strong. This last week I’m experiencing the same thing.. calling for another eye exam tomorrow! Eye strain started within my last two imipramine tapers. I really think the last one has changed my eyesight again 😁

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

April 1Apr 1

2 hours ago, Tulip said:

really think the last one has changed my eyesight again 😁

It wouldn’t shock me tbh!

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

April 5Apr 5

Author

So glad I tapered the mirapex. My restless legs is actually better on this lower dose and I’m sleeping better.

I’m super excited to be down to 14mg of imipramine. I am 94% done with this ever so slow taper. Things are good!

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

April 6Apr 6

54 minutes ago, Tulip said:

So glad I tapered the mirapex. My restless legs is actually better on this lower dose and I’m sleeping better.

I’m super excited to be down to 14mg of imipramine. I am 94% done with this ever so slow taper. Things are good!

Well done with the TCA taper @Tulip! I’m soon to embark on an Amitriptyline taper, from 20mg to 10mg. I’ve had such awful side effects. Have you had side effects too?

Link to SA Profile: https://www.survivingantidepressants.org/forums/topic/32414-catbird-introduction-a-long-and-winding-road/

1996 Commenced on Sertraline 50 - 100mg. Many ADs trialled -Fluoxetine 20 mg, Paroxetine 20mg, Venlafaxine 75mg, Escitalopram 10 - 20mg, Vortioxetine 20mg, Bupropion 150mg. 2019 Recommenced Escitalopram 2022 Mirtazapine 30mg - Rapid taper. Amitriptyline 20mg

CURRENT MEDICATIONS: Escitalopram taper from ~ 10mg commenced 2024, Amitriptyline 20mg at night, Diazepam 7.5mg total per day, Baclofen 10mg morning, 10mg lunch and 20mg night, Polaramine 2mg at night, Ketamine troche 25mg per day (Ceased early September 2025), Valsartan 160mg evening, HRT (Oestrogen 25mcg/day)

ESCITALOPRAM TAPER: 5 April 2025 - started holding at 1.516mg. Escitalopram taper resumed July 2025; End Aug 1.364; End Sept 1.228; End Oct 1.145; End Nov 1.1 Early Dec 1.11; End Dec 1.082; 2026 End Jan 1.047; Feb 6 1.030; Feb 20 1.014; April 10 1.012; May 3 1.014; May 11 1.010 & still holding

Supplements: Mg++ glycinate, Omega 3s, Curcumin. Vit D3/K2 spray, Vitamin B12 spray, chelated zinc.

April 6Apr 6

1 hour ago, Tulip said:

So glad I tapered the mirapex. My restless legs is actually better on this lower dose and I’m sleeping better.

I’m super excited to be down to 14mg of imipramine. I am 94% done with this ever so slow taper. Things are good!

Great news, well done! may it stay that well the rest of the way 🙏

Edited April 6Apr 6 by Fullhealing

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 21.7% 0.0356.5g (2mg)/15.8 updose by 11.7% 0.0400g (2.23mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of terror, body pain and sleep.

April 6Apr 6

4 hours ago, Tulip said:

So glad I tapered the mirapex. My restless legs is actually better on this lower dose and I’m sleeping better.

I’m super excited to be down to 14mg of imipramine. I am 94% done with this ever so slow taper. Things are good!

This is great news! Good to hear.

Now slow and steady. You seem to be doing well. 👍 If you want to talk about taper plans from here, make sure you check in with us. No sudden dose changes or drops. 😀

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

April 14Apr 14

On 3/17/2026 at 4:48 PM, Tulip said:

@getofflexare you here? Any others from SA here?

Yes, I'm here, but I can't be here regularly. Got a lot on my plate at the time. I'm glad to hear things are going well for you!

Only tag me for urgent questions about tapering and reinstating - thank you.

***Please note this is not medical advice. Discuss any decisions about your medical care with a doctor who understands psych meds and how to withdraw from them.

Paxil 2002 - 2010, Dr. abruptly switched to Lexapro 2010, no issues

Trazodone 50 mg. 2002 - 2019, fast tapered in 2019

Xanax 0.5 mg as needed 2002 - 2019, up to 3x weekly

Lexapro Started Apr 15 2010 - 10 mg; started taper August 2017, recent taper info: Apr 2 '20 0.18 mg; Jul 16 0.17 mg, Aug 23 0.16 mg, Oct 7 0.15 mg, Nov 8 - 0.14, Jan 16 '21 - 0.13, Feb 7 - 0.12, Feb 22 - 0.11, Mar 26 - 0.10, May 21 - 0.09, June 15 - 0.08 Aug 16 - 0.07, Oct 6 - 0.06, Nov 21 0.05, Dec. 17 0.04, Jan 14 '22 0.03, Feb 19 0.02, Apr 18 0.01, May 15 0.005, Jul 8, 0.00. Psych Drug Free as of July 8, 2022!! Woohoo!!!

other meds: Levothyroxine 75 mg

suppl 3:30 - 4:00 AM: melatonin 2 mg, Lactium 167 mg, magnesium lysinate glycinate chelated 200 mg., vitamin C 250 mg

suppl 7:00 AM: high quality fish oil, vit E, multivitamin, zinc

suppl 8 PM: magnesium citrate 350 mg, melatonin 2 mg, Lactium milk protein hydrolysate 167 mg, aspirin 325 mg

July 19Jul 19

Author

Since getting down to lower doses I’ve noticed each time I taper my restless legs is much worse. I went down to 14 mg and my system settled down about a week later. I gradually got down to 10mg and now suddenly every night about an hour after I take the imioramine the restless legs is so bad I can barely stand it. I experimented and skipped the imipramine completely a couple of nights and my restless legs was completely back in control with the medication I take for it. I’ve tried lowering the dose to see if that would help, still crazy restless. What do I do?

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

July 19Jul 19

From what I could think of, you may have tapered the drug too fast, since when you went down to 14mg it did pass after 1 week but after that you tapered more, it came to a certain point the restless legs require a longer time to pass. generally the lower doses do most of the effect on the receptors with these drugs.

25 minutes ago, Tulip said:
I experimented and skipped the imipramine completely a couple of nights

Please try to avoid skipping doses. as it can cause more instability which will take longer to recover from.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.
Feel free to mention me whenever help is needed.

Current Supplements: Morning: Aloe Vera Gels. Night: 6mg melatonin and 133mg magnesium glycinate. Taking Omega 3 as needed to calm dyskinesia or over stimulation..

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

1

July 19Jul 19

Author

No, i meant that after I got to 14 it took about a week for the restless legs to settle down. I didn’t taper again for a few more weeks. I’ve been tapering very slowly for 6 years.

Edited July 19Jul 19 by Tulip

1994-2002 several different SSRI’s, klonopin.
2002 ct klonopin, 2 wks later put back on klonopin, added Seroquel & lexapro,

2002 weaned klonopin 2003 weaned off seroquel. 2006 Ct lexapro,

2007 imipramine 250mg, 2016-2017 150mg, 2017-2019 100 mg, Jan 2020 50mg, 2 weeks later 60 mg November 2022 56 mg December 2022 50mg 4/5/23 47mg April 2023 40mg june 23,2023 35mg, April 15, 2024 33mg, May 15, 2024 32mg, 5/27/24 30mg, 6/09/24 29mg, 6/14 28mg, 8/2 27mg, 12/9/24 26mg 12/28/24 25mg 10/11/25 20mg, 3/13/26 14mg

2023 Mirapex .75, March 2026 .5 Mirapex

December 2025 Ativan .5 in an, .5 in pm

Supplements: cream of tartar and Celtic sea salt, transdermal magnesium oil

July 19Jul 19

13 minutes ago, Tulip said:
No, i meant that after I got to 14 it took about a week for the restless legs to settle down. I didn’t taper again for a few more weeks. I’ve been tapering very slowly for 6 years.

how did you do your steps after that ? can you update your signature with a date of each reduction, and to what dose did you reduce ?

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.
Feel free to mention me whenever help is needed.

Current Supplements: Morning: Aloe Vera Gels. Night: 6mg melatonin and 133mg magnesium glycinate. Taking Omega 3 as needed to calm dyskinesia or over stimulation..

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

July 19Jul 19

4 hours ago, Tulip said:
Since getting down to lower doses I’ve noticed each time I taper my restless legs is much worse. I went down to 14 mg and my system settled down about a week later. I gradually got down to 10mg and now suddenly every night about an hour after I take the imioramine the restless legs is so bad I can barely stand it. I experimented and skipped the imipramine completely a couple of nights and my restless legs was completely back in control with the medication I take for it. I’ve tried lowering the dose to see if that would help, still crazy restless. What do I do?

Hi @Tulip are you tapering hyperbolically?

Link to SA Profile: https://www.survivingantidepressants.org/forums/topic/32414-catbird-introduction-a-long-and-winding-road/

1996 Commenced on Sertraline 50 - 100mg. Many ADs trialled -Fluoxetine 20 mg, Paroxetine 20mg, Venlafaxine 75mg, Escitalopram 10 - 20mg, Vortioxetine 20mg, Bupropion 150mg. 2019 Recommenced Escitalopram 2022 Mirtazapine 30mg - Rapid taper. Amitriptyline 20mg

CURRENT MEDICATIONS: Escitalopram taper from ~ 10mg commenced 2024, Amitriptyline 20mg at night, Diazepam 7.5mg total per day, Baclofen 10mg morning, 10mg lunch and 20mg night, Polaramine 2mg at night, Ketamine troche 25mg per day (Ceased early September 2025), Valsartan 160mg evening, HRT (Oestrogen 25mcg/day)

ESCITALOPRAM TAPER: 5 April 2025 - started holding at 1.516mg. Escitalopram taper resumed July 2025; End Aug 1.364; End Sept 1.228; End Oct 1.145; End Nov 1.1 Early Dec 1.11; End Dec 1.082; 2026 End Jan 1.047; Feb 6 1.030; Feb 20 1.014; April 10 1.012; May 3 1.014; May 11 1.010 & still holding

Supplements: Mg++ glycinate, Omega 3s, Curcumin. Vit D3/K2 spray, Vitamin B12 spray, chelated zinc.

Tulip: Imipramine

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