Mittenraised: Seroquel tapering from 250 MG

March 26Mar 26

Author

Thanks, @N2deep. I would be lost without my coffee. I am fortunate that I can still tolerate my morning wake up cup.

I see your photo has a motorcycle. Do you ride? I'm a motorcycle junkie.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

March 26Mar 26

No ... not yet anyway. I'm just a big fan of road racing - like they have in parts of the UK and Europe (Isle of Man TT, North West 200 etc). You're not the first person to ask me that on here so I think I'd better change my picture as I kinda feel like a poser now 🤣

I can imagine one becoming a junkie (and that becoming excessively expensive) as I can see wanting sport bikes and dual-sports and cruisers and freakin Goldwings ... everything. What are you into?

Olanzapine (5mg) started June 2023 - This is the only drug I'm currently taking. I haven't used any other psych drugs.

After 4 weeks dropped to 2.5mg for 5 days then dropped to 1.25mg for 3 days (all on doctor's orders) - Severe withdrawal symptoms commenced. I then took a single dose of 3.75mg, then went to 2.5mg on July 19/23 and held.

Sept28/2023: -2.5%Oct5: -2.5%Oct12: -2.5%Oct19: -5%Oct29: -5%Nov10: 2.0mg Nov20: 1.9mg Nov30: 1.8mg Dec12: 1.75mg Dec22: 1.70mg Dec29: 1.65mg Jan 06/2024: 1.60mg Jan14: 1.55mg Jan25: 1.50mg Feb12: Updose to 1.55mg Apr25: 1.50mg May22: 1.45mg Jun5: 1.40mg Jun25: 1.35mg Jul24: 1.30mg Aug7: 1.25mg Aug21: 1.20mg Sept4: 1.15mg Sept18: 1.10mg Oct2: 1.05mg Oct18: 1mg Nov1: 0.95mg Nov15: 0.90mg Nov29: 0.85mg Dec18: 0.80mg Jan 17/2025: 0.75mg Feb5: 0.725mg Feb15: 0.70mg Feb26: 0.675mg Mar8: 0.65mg Mar19: 0.625mg Mar30: 0.60mg Apr10: 0.575mg Apr23: 0.55mg May14: 0.525mg Jun10: 0.50mg Jun24: 0.475mg Jul8: 0.45mg Jul23: 0.425mg Aug13: 0.40mg Aug31: 0.375mg Sept18: 0.35mg Oct7: 0.325mg Oct27: 0.30mg Nov17: 0.275mg Dec8: 0.25mg Jan 13/2026: 0.225mg Jan26: 0.2125mg Feb8: 0.20mg Feb 21: 0.1875mg Mar7: 0.175mg Mar22: 0.1625mg Apr4: 0.15mg Apr18: 0.1375mg May2: 0.125mg ... Aug9: 0.075mg Aug20: 0.07mg Aug 30: 0.065mg

I lack hubris and read academic literature - so it's safe to say I'm not a medical professional. Nothing I say should be taken as medical advice.

1

March 29Mar 29

Author

@N2deep, I love watching the Isle of Man TT! I ride a BMW K1600GT, GS1200 and a few other crotch rockets that have come and gone through my garage. The tapering slowed my riding down some in the beginning. Im getting to old for anything too crazy. Motorcycles are good for the soul, they make me smile.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

March 29Mar 29

On 3/26/2026 at 4:50 PM, Mittenraised said:

I would be lost without my coffee. I am fortunate that I can still tolerate my morning wake up cup.

I'm a big tea enthusiast and haven't drank tea for a year and a half, I managed to return to it in March, after I had a dream, and I was scared to try but was so hopeless depressed I didn't care, turns out I can tolerate it. I feel the same like you.

5 hours ago, Mittenraised said:

@N2deep, I love watching the Isle of Man TT! I ride a BMW K1600GT, GS1200 and a few other crotch rockets that have come and gone through my garage. The tapering slowed my riding down some in the beginning. Im getting to old for anything too crazy. Motorcycles are good for the soul, they make me smile.

That's cool, it can be pretty fun I imagine, my mom has instilled fear in me from motorcycles since age 0 so I will never have one hahaha, probably not a bad thing.

I really like to watch snooker sometimes, It's an interesting sport with tons of aspects and complexitiy, I love those kind of stuff, tea is also a big rabbit hole people in the west aren't aware of haha.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.
Feel free to mention me whenever help is needed.

Current Supplements: Morning: Aloe Vera Gels. Night: 6mg melatonin and 133mg magnesium glycinate. Taking Omega 3 as needed to calm dyskinesia or over stimulation..

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

March 29Mar 29

9 hours ago, Lighty said:

my mom has instilled fear in me from motorcycles since age 0 so I will never have one hahaha, probably not a bad thing.

I always wanted a sport bike since I was a kid but then a guy I know got in a life-altering crash on one - which kinda put the fear in me for a very long time. That said I still want one. Though I'm kind of more interested in learning to get good on a track - alas, there aren't any around me.

You're clearly riding in style, Mittenraised.

Olanzapine (5mg) started June 2023 - This is the only drug I'm currently taking. I haven't used any other psych drugs.

After 4 weeks dropped to 2.5mg for 5 days then dropped to 1.25mg for 3 days (all on doctor's orders) - Severe withdrawal symptoms commenced. I then took a single dose of 3.75mg, then went to 2.5mg on July 19/23 and held.

Sept28/2023: -2.5%Oct5: -2.5%Oct12: -2.5%Oct19: -5%Oct29: -5%Nov10: 2.0mg Nov20: 1.9mg Nov30: 1.8mg Dec12: 1.75mg Dec22: 1.70mg Dec29: 1.65mg Jan 06/2024: 1.60mg Jan14: 1.55mg Jan25: 1.50mg Feb12: Updose to 1.55mg Apr25: 1.50mg May22: 1.45mg Jun5: 1.40mg Jun25: 1.35mg Jul24: 1.30mg Aug7: 1.25mg Aug21: 1.20mg Sept4: 1.15mg Sept18: 1.10mg Oct2: 1.05mg Oct18: 1mg Nov1: 0.95mg Nov15: 0.90mg Nov29: 0.85mg Dec18: 0.80mg Jan 17/2025: 0.75mg Feb5: 0.725mg Feb15: 0.70mg Feb26: 0.675mg Mar8: 0.65mg Mar19: 0.625mg Mar30: 0.60mg Apr10: 0.575mg Apr23: 0.55mg May14: 0.525mg Jun10: 0.50mg Jun24: 0.475mg Jul8: 0.45mg Jul23: 0.425mg Aug13: 0.40mg Aug31: 0.375mg Sept18: 0.35mg Oct7: 0.325mg Oct27: 0.30mg Nov17: 0.275mg Dec8: 0.25mg Jan 13/2026: 0.225mg Jan26: 0.2125mg Feb8: 0.20mg Feb 21: 0.1875mg Mar7: 0.175mg Mar22: 0.1625mg Apr4: 0.15mg Apr18: 0.1375mg May2: 0.125mg ... Aug9: 0.075mg Aug20: 0.07mg Aug 30: 0.065mg

I lack hubris and read academic literature - so it's safe to say I'm not a medical professional. Nothing I say should be taken as medical advice.

March 30Mar 30

Author

Slight sleep disruption. Going ok, if that's all I have to deal with, I feel blessed.

I'm gonna try and jump off at 2 mg. That follows the info I read on SA. If it doesn't work, I'll reinstate and keep going lower.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

March 30Mar 30

1 hour ago, Mittenraised said:

Slight sleep disruption. Going ok, if that's all I have to deal with, I feel blessed.

I'm gonna try and jump off at 2 mg. That follows the info I read on SA. If it doesn't work, I'll reinstate and keep going lower.

It’s better to step off rather than jump of of anything. Ri isn’t a good back up plan. Low and slow to the finish line would be my thoughts 😀

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

April 23Apr 23

Author

2.6 mg. Getting closer...

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

April 23Apr 23

1 hour ago, Mittenraised said:
2.6 mg. Getting closer...

🎉 😀

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

June 2Jun 2

Author

2.25 mg. Steady as she goes. Had a rough patch, back to "normal".

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

June 2Jun 2

7 hours ago, Mittenraised said:
2.25 mg. Steady as she goes. Had a rough patch, back to "normal".

Great hear :)

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

June 2Jun 2

Hi @Mittenraised. Nice to see someone on here tapering seroquel. I’m currently on a relatively low dose (12.5 mg) and hope to start my taper once things have settled down following several drugs changes that have left me very unstable.

I’m having a hard time finding tapering resources specific to seroquel/antipsychotics generally. I found a copy of the index to the Maudsley Deprescribing Guidelines online and it doesn’t look like they cover antipsychotics. I did find one paper by Horowitz and others that suggested you could jump off seroquel at 20 mg — which seems crazy high!!

Can I ask if there are any specific resources you used to guide your taper, especially at lower doses?

Edited June 2Jun 2 by SarahMc

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

1

June 3Jun 3

Author

Hi @SarahMc ,

I followed FeralCatman at Survivingantidepressants.org. I water titrate the immediate acting pill.

Taper 10% of my last dose, each month. Sometimes longer, sometimes sooner. You can tell, your body speaks to you through discomfort. If I need to, I wait. I plan to discontinue around 1 mg. I had a friend at SA that stopped at 2 mg. She was OK. Everyone is different. Let me know when you start, I'll help as much as I can. Stay healthy! ~M

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

June 3Jun 3

Thanks very much @Mittenraised. I get the feeling it’s going to take a pretty long hold for me to stabilize, but I’ll certainly reach out when I’m ready to start tapering. I appreciate you offering to help!

Sounds like your taper has been going relatively smoothly, that’s great to see. Hope it continues that way for you 😊

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

June 3Jun 3

Author

Hi @SarahMc.

I've had a few rough patches. Mostly insomnia when I push too fast. Allergies and other histamine related issues. They were at the higher doses, while tapering.

The insomnia really is the biggest factor, it makes everything else harder.

Stay healthy, ~M

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

June 3Jun 3

37 minutes ago, Mittenraised said:
The insomnia really is the biggest factor, it makes everything else harder.

100%. I’ve heard that the insomnia can be really bad when coming off seroquel. The last big mistake I made before I found this site and decided to stabilize on my current meds was trying to come off my seroquel dose really fast. I think I got like 3-4 hours of sleep per night for a couple weeks before giving up.

Hope you’ve been sleeping ok since your latest reduction.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

1

June 4Jun 4

Author

Tonight is when the symptoms show up. Day 3 or 4. I'll know tomorrow! Thanks for the conversation, I appreciate talking to others in my situation. We can recover and get well. It just takes time, patience and iron will perseverance.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

June 12Jun 12

Author

This last one went pretty smooth. I wish they were all that easy.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

June 12Jun 12

7 hours ago, Mittenraised said:
This last one went pretty smooth. I wish they were all that easy.

Glad to hear it!

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

July 1Jul 1

Author

2.0 mg tonight. Hopefully, as good as last month.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

2

July 1Jul 1

4 hours ago, Mittenraised said:
2.0 mg tonight. Hopefully, as good as last month.

Steady with your reductions, Im glad they are going well but your %s have been a bit quick, it can seem like things are going well, then the symptoms stack and you can crash. Lower the slower........

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

July 3Jul 3

Author

On 7/1/2026 at 3:43 AM, Chippy said:
Steady with your reductions, Im glad they are going well but your %s have been a bit quick, it can seem like things are going well, then the symptoms stack and you can crash. Lower the slower........

@Chippy ,

I've been at it for 3.5 years. I have figured out what I can tolerate. It's almost clockwork.

I am fortunate my body seems to handle 12% reductions.

~M

Edited July 3Jul 3 by Mittenraised

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

July 3Jul 3

Mittenraise, welcome to the forum, It's good to see that your in tune with what your system is telling you. I vaguely remember when I hit 3mg of Citalopram my system did not handle any caffeine, and I do like my chocolate and I had to give that up to. More things started to effect my system the lower I got and yes insomnia was a big one as it is for so many of us here. Your doing great and glade you are so in tune with your body and what is telling you.

Dec 23 Citalopram 15mg

13 March 24 13.5mg

27 March 24 10mg

12 March 24 7.5mg

20 March 24 6mg

10 Aug 24 5mg

24 Aug 24 4mg

2 Sept 24 3.5mg

11 Sept 24 3mg

19 Sept 24 2.5mg

26 Sept 24 2mg

5 Oct 24 1.5mg

12 Oct 24 1mg

17 Oct 24 Jumped off.

2

July 3Jul 3

7 hours ago, Mittenraised said:
@Chippy ,
I've been at it for 3.5 years. I have figured out what I can tolerate. It's almost clockwork.
I am fortunate my body seems to handle 12% reductions.
~M

That is good to hear, glad your taper is going so well for you. Be aware the lower you go the harder it is, you may find you'll need to slow at some point.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

July 7Jul 7

Author

The insomnia or early waking showed up on the 3rd night. A few more days and it will be gone.

One foot in front of the other... slow process but almost there!

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

2

Mittenraised: Seroquel tapering from 250 MG

Featured Replies

Top Posters In This Topic

Most Popular Posts

Chippy

Mittenraised

Bernadette

Create an account or sign in to comment

Top Posters In This Topic

Most Popular Posts

Chippy

Mittenraised

Bernadette

Account

Navigation

Search

Configure browser push notifications

Chrome (Android)

Chrome (Desktop)

Safari (iOS 16.4+)

Safari (macOS)

Edge (Android)

Edge (Desktop)

Firefox (Android)

Firefox (Desktop)