Mittenraised: Seroquel tapering from 250 MG

July 12Jul 12

Author

I can honestly say, it takes a full 10 days to feel "normal" after tapering. 3 to 4 rough days with very little sleep or recovery, 6 so-so nights of broken sleep then it's right back to regular business.

The human body is an amazing machine when you let it do its thing.

~M

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

2

July 12Jul 12

22 minutes ago, Mittenraised said:
I can honestly say, it takes a full 10 days to feel "normal" after tapering. 3 to 4 rough days with very little sleep or recovery, 6 so-so nights of broken sleep then it's right back to regular business.
The human body is an amazing machine when you let it do its thing.

Glad to hear things are still going pretty smoothly for you. I hope to be in your shoes sometime soon!

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

July 14Jul 14

Author

On 7/12/2026 at 5:58 PM, SarahMc said:
Glad to hear things are still going pretty smoothly for you. I hope to be in your shoes sometime soon!

Thanks @SarahMc ! You will get there too.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

July 25Jul 25

Author

6 days out from my drop it 1.8 MG. I had a few high stress days; work and home life. It really effects the sleep patterns.

I've recovered but rest, sleep and recovery are a top priority.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

August 1Aug 1

Author

1.8 MG tonight... getting closer!

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

August 1Aug 1

👍

1998 -1999 Paxil CT after 5 months.

1999 - 2024 every 2 to 4 years went from one SSRI to the next. That includes Luvox, Zoloft, Cymbalta, Celexa, Prozac, Lexapro.

2000-2024 lorazepam 2mg.

April 2024 one dose of Effexor, July 2024 one dose of Paxil, July 2024 two weeks of Mirtazapine. September 2024 Lexapro 10mg, Depakote 250mg, Vistaril 25 mg ,Proppranolol 10mg, Requip 2mg Trazadone 50mg. March 2025 off Depakote,Propranolol,vistaril,Trazadon.

March 2025 Zyprexa added at 2.5 mg.”for sleep and anxiety”. Went up to 7.5mg in June.

September 2025 started tapering Zyprexa and Requip.

February 2026 off of Zyprexa and Requip. Reduced Lexapro to 5mg

7/4/2026-4.5mg

8/1/2026-4.0mg

1

August 12Aug 12

Author

A few light sleep nights. Nothing significant. Caffeine late is still an issue, even chocolate ice cream.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

August 12Aug 12

4 hours ago, Mittenraised said:
A few light sleep nights. Nothing significant. Caffeine late is still an issue, even chocolate ice cream.

Glad things are not too bad. Yes I think keeping the caffeine to a min and only earlier in the day is a good move. I noticed dark chocolate made my sleep worse at one point.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

September 1Sep 1

Author

1.62 MG tonight!

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

2

September 3Sep 3

Author

So far so good. Sleep is consistent; no discomfort. I hope it's like this the rest of the way!

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

2

September 3Sep 3

5 hours ago, Mittenraised said:
So far so good. Sleep is consistent; no discomfort. I hope it's like this the rest of the way!

Oh 100% lovin the positivity over here @Mittenraised great to see :)

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

September 3Sep 3

9 hours ago, Mittenraised said:
So far so good. Sleep is consistent; no discomfort. I hope it's like this the rest of the way!

Amazing -- so glad to hear it!

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

1

September 12Sep 12

Author

1.5 MG. 10 days since my last drop. I hope to discontinue sometime in December.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

September 12Sep 12

8 hours ago, Mittenraised said:
1.5 MG. 10 days since my last drop. I hope to discontinue sometime in December.

Glad things are still going smoothly. What do you plan to be your final dose?

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

September 13Sep 13

Author

Hi @SarahMc,

I hope just under 1mg. It follows the information I read relative to getting under 1% receptor occupancy and also under 1% of my original dose. (300 MG)

If the trend continues, I should be able to make December work.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1

September 13Sep 13

8 minutes ago, Mittenraised said:
I hope just under 1mg. It follows the information I read relative to getting under 1% receptor occupancy and also under 1% of my original dose. (300 MG)

Ok, thanks! I'll be following the end of your taper with interest ahead of my own.

Also, as an aside, I just checked out your thread on SA and I find it WILD that you were prescribed 300 mg for sleep!! I've never heard of more than 100 mg being prescribed for sleep, and that's on the high end.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

September 14Sep 14

Author

@SarahMc ,

Yup, that is a big problem. You trust your doctor to look out for your health and well being. Unfortunately, most are bought by the pharmaceutical industry and are really just drug dealers with an education. I don't take anything without thorough research first.

I will be sure to post here after I discontinue. I want to help other folks that are in our predicament. I remember how hopeless I felt, then I found SA and it was a lifesaver.

It's been challenging and uncomfortable for several years but it does get better and our bodies do heal. Even at 57 years old!

Stay healthy, ~M

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

1
2

September 14Sep 14

14 hours ago, Mittenraised said:
Yup, that is a big problem. You trust your doctor to look out for your health and well being. Unfortunately, most are bought by the pharmaceutical industry and are really just drug dealers with an education. I don't take anything without thorough research first.

This is definitely a lesson I've learned the hard way, as have many on here I'm sure.

14 hours ago, Mittenraised said:
I will be sure to post here after I discontinue. I want to help other folks that are in our predicament. I remember how hopeless I felt, then I found SA and it was a lifesaver.
It's been challenging and uncomfortable for several years but it does get better and our bodies do heal. Even at 57 years old!
Stay healthy, ~M

Thanks, I think the more people who post here after they've discontinued and especially after they've healed, the better. We all need those hopeful stories and it looks like you're well on your way to being one of them 😊

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys.

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

1

September 15Sep 15

Yours is an example of a disciplined well-executed taper, sir.

Olanzapine (5mg) started June 2023 - This is the only drug I'm currently taking. I haven't used any other psych drugs.

After 4 weeks dropped to 2.5mg for 5 days then dropped to 1.25mg for 3 days (all on doctor's orders) - Severe withdrawal symptoms commenced. I then took a single dose of 3.75mg, then went to 2.5mg on July 19/23 and held.

Sept28/2023: -2.5%Oct5: -2.5%Oct12: -2.5%Oct19: -5%Oct29: -5%Nov10: 2.0mg Nov20: 1.9mg Nov30: 1.8mg Dec12: 1.75mg Dec22: 1.70mg Dec29: 1.65mg Jan 06/2024: 1.60mg Jan14: 1.55mg Jan25: 1.50mg Feb12: Updose to 1.55mg Apr25: 1.50mg May22: 1.45mg Jun5: 1.40mg Jun25: 1.35mg Jul24: 1.30mg Aug7: 1.25mg Aug21: 1.20mg Sept4: 1.15mg Sept18: 1.10mg Oct2: 1.05mg Oct18: 1mg Nov1: 0.95mg Nov15: 0.90mg Nov29: 0.85mg Dec18: 0.80mg Jan 17/2025: 0.75mg Feb5: 0.725mg Feb15: 0.70mg Feb26: 0.675mg Mar8: 0.65mg Mar19: 0.625mg Mar30: 0.60mg Apr10: 0.575mg Apr23: 0.55mg May14: 0.525mg Jun10: 0.50mg Jun24: 0.475mg Jul8: 0.45mg Jul23: 0.425mg Aug13: 0.40mg Aug31: 0.375mg Sept18: 0.35mg Oct7: 0.325mg Oct27: 0.30mg Nov17: 0.275mg Dec8: 0.25mg Jan 13/2026: 0.225mg Jan26: 0.2125mg Feb8: 0.20mg Feb 21: 0.1875mg Mar7: 0.175mg Mar22: 0.1625mg Apr4: 0.15mg Apr18: 0.1375mg May2: 0.125mg ... Aug9: 0.075mg Aug20: 0.07mg Aug30: 0.065mg Sep4: 0.0625mg Sep13: 0.0575mg Sep23: 0.0525 Oct4: 0.0475mg

Nothing I say should be taken as medical advice.

1
1

October 1Oct 1

Author

1.35 MG tonight. I'm able to nap lightly in the evenings, that wasn't possible a year ago.

Getting closer.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

2

October 8Oct 8

Author

Almost back to normal; if there is such a thing.

I plan on tapering to just under 1 MG and discontinuing. It follows the receptor occupancy recommendations I have read and is well under 1% of my initial dose.

Seroquel taper- Dropped 10% to 225 mg-2/3/23, 200mg XR 2/19/23, 180 XRmg 3/20/23, 162 XRmg 4/25/23, 150 XR 5/25/23, 7/31/23 137.5mg XR & IR, 9/4/23 125mg (100mg XR,25mg IR) 9/21/23, (100mg XR, 12.5mg IR) 10/28/23, (100mg XR) 11/19/23, (50mg XR, 50mg IR) 12/8/23, (50mg XR, 42mg IR) 1/1/24, 82.8mg 2/7/24, 75mg 2/22/24, 67.5mg 3/22/24, 61mg 5/6/24, 54.9mg 5/31/24, 50mg 6/15/24, 45mg 7/16/24, 40.5mg 8/16/24, 36mg 9/16/24, 31.5mg 10/22/24, 28mg 12/4/2024, 25mg 12/25/24, 22.5mg 1/24/25, 20mg 2/14/24, 18mg 3/7/25, 16.2mg, 4/3/25, 14.6mg 5/2/25, 12 mg, 6/1/25, 10.5 mg, 6/28/25, 9.45 mg, 7/16/25, 8.5 mg, 8/6/25, 7.65mg, 8/20/25, 6.9 mg 9/11/25, 6.2 mg 9/27/25, 5.6 mg 10/13/25, 5.0 mg 11/2/25, 4.5 mg 11/23/25, 4.0 mg 12/14/25, 3.6 mg 1/10/26, 3.25 mg 2/27/26, 2.9 mg 3/26/26, 2.6 mg 4/21/26, 2.25 mg 6/1/26, 2.0 mg 6/30/26, 1.8 MG 7/31/26, 1.62 MG 8/31/26, 1.50 MG 9/10/26, 1.35 MG 9/30/26, 1.215 MG 10/11/26.

Supplements- Magnesium Glycinate 420mg, 1000mg fish oil twice daily, Niacinamide 500mg- 3 daily, L-Theanine 200mg- 2 daily.

2

October 12Oct 12

If you're still having symptoms during drops you might just want to keep going lower, at the very least until you don't. And I always espouse speeding up rather than jumping. I've seen a number of people keep it to 10% per month, and then out of nowhere, just jump off the drug; which I don't understand. If a person has it in their mind to jump, then to me it makes all the sense in the world to just do a 25% or 50% cut and see how that goes first. Or start doing 15%-30% per month - and see how you feel. I've been going around or over 20% per month for quite a while because I'm going to go as low as I can - but fast(er).

The 1% of original dose thing is tricky because on your drug people take anywhere from 25mg to 1000mg.

Olanzapine (5mg) started June 2023 - This is the only drug I'm currently taking. I haven't used any other psych drugs.

After 4 weeks dropped to 2.5mg for 5 days then dropped to 1.25mg for 3 days (all on doctor's orders) - Severe withdrawal symptoms commenced. I then took a single dose of 3.75mg, then went to 2.5mg on July 19/23 and held.

Sept28/2023: -2.5%Oct5: -2.5%Oct12: -2.5%Oct19: -5%Oct29: -5%Nov10: 2.0mg Nov20: 1.9mg Nov30: 1.8mg Dec12: 1.75mg Dec22: 1.70mg Dec29: 1.65mg Jan 06/2024: 1.60mg Jan14: 1.55mg Jan25: 1.50mg Feb12: Updose to 1.55mg Apr25: 1.50mg May22: 1.45mg Jun5: 1.40mg Jun25: 1.35mg Jul24: 1.30mg Aug7: 1.25mg Aug21: 1.20mg Sept4: 1.15mg Sept18: 1.10mg Oct2: 1.05mg Oct18: 1mg Nov1: 0.95mg Nov15: 0.90mg Nov29: 0.85mg Dec18: 0.80mg Jan 17/2025: 0.75mg Feb5: 0.725mg Feb15: 0.70mg Feb26: 0.675mg Mar8: 0.65mg Mar19: 0.625mg Mar30: 0.60mg Apr10: 0.575mg Apr23: 0.55mg May14: 0.525mg Jun10: 0.50mg Jun24: 0.475mg Jul8: 0.45mg Jul23: 0.425mg Aug13: 0.40mg Aug31: 0.375mg Sept18: 0.35mg Oct7: 0.325mg Oct27: 0.30mg Nov17: 0.275mg Dec8: 0.25mg Jan 13/2026: 0.225mg Jan26: 0.2125mg Feb8: 0.20mg Feb 21: 0.1875mg Mar7: 0.175mg Mar22: 0.1625mg Apr4: 0.15mg Apr18: 0.1375mg May2: 0.125mg ... Aug9: 0.075mg Aug20: 0.07mg Aug30: 0.065mg Sep4: 0.0625mg Sep13: 0.0575mg Sep23: 0.0525 Oct4: 0.0475mg

Nothing I say should be taken as medical advice.

Mittenraised: Seroquel tapering from 250 MG

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