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Troy021079: Short term use Pristiq and quetiapine, ADR?

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  • Author
53 minutes ago, Lighty said:

it's all temporary, it's important to just let the symptoms take over and 'surrender' to them in a way instead of fighting them when they are too strong, makes it 10x easier, either way you got this as you are improving.

I have been trying to allow more which can be hard in a wave but I'm not letting symptoms control me as much. I let them sit on my shoulder while I get on with things, I don't do this perfectly but I keep practicing it as well as I can 🙏

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

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  • Absolutely 100%!!!! It feels like it will never end, and that you will be like this for the rest of your life. The waves should eventually start getting shorter and the windows longer. Keep perseve

  • Chippy
    Chippy

    Worsening isn’t uncommon unfortunately. It’s best to try to keep stress levels lower, whilst you recover. Obviously life is life, but avoid the stress you can. Your health and healing journey is the m

  • You said: I am not being hostile, I can only go by what you tell us. Flare ups can be caused by a large range of things, stress can be one of them, although for some, there doesn't seem be much of

19 hours ago, Troy021079 said:

I let them sit on my shoulder while I get on with things, I don't do this perfectly but I keep practicing it as well as I can 🙏

Nobody does Troy, the perfect way is to do it imperfectly but keep trying. As you say, all we can do.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author
12 minutes ago, Chippy said:

Nobody does Troy, the perfect way is to do it imperfectly but keep trying. As you say, all we can do.

It's so hard to do sometimes, especially in a wave when symptoms are screaming at you. It hits even harder after a good period!

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

37 minutes ago, Troy021079 said:

It's so hard to do sometimes, especially in a wave when symptoms are screaming at you. It hits even harder after a good period!

It is, you have the perfect attitude, you accept it is hard but keep trying all the same.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author
23 minutes ago, Chippy said:

It is, you have the perfect attitude, you accept it is hard but keep trying all the same.

Something like, it's hard today but I'm still going to work and doing my thing.

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

  • Author

Why does a wave always feel like a step back and that it's endless, does anyone else feel this when they're in one? Sorry, struggling a bit with this as I really thought I turned a corner until this bloody flare.

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

8 minutes ago, Troy021079 said:

Why does a wave always feel like a step back and that it's endless, does anyone else feel this when they're in one? Sorry, struggling a bit with this as I really thought I turned a corner until this bloody flare.

Yeah unfortunately this is really common and normal. Loads of times I thought I'd turned a corner and when I got hit again was devastated.

Just know the good times will come again and eventually start to last longer.

Think almost everyone here can relate to this. ❤️

You'll get there again

2016 - Sertraline 50mg

2016 - Sertraline 100mg.

I didnt know better and rarely took it consistently.

June 2024 - went down to 75mg

2025 - Down to 50mg

2026 - down to 25mg

April 2026 - hit by withdrawal and kindling

Reinstated April 2026 - 25mg

May 27th 2026 - Upped to 50mg

Absolutely 100%!!!!

It feels like it will never end, and that you will be like this for the rest of your life.

The waves should eventually start getting shorter and the windows longer.

Keep persevering.

Wombat

1998 Paroxetine 20mg, getting to 60mg and staying there for many years.

Started reducing by 10mg at a time, December 2018 to June 2019. At 30mg held for 2 and a half years.

Beginning 2023, start micro tapering from 30mg

End 2023 - 18.76. End 2024 - 13.37. End 2025 - 8.58 

2026 - 31 Jan - 8.38, 15 Feb - 8.19, 07 March - 8.06, 14 March - 8.00, 08 April - holding and start liquid transition, 22 May completed liquid transition 8mg (16ml) held for 1 month

27 June - 7.9, 12 July - 7.75, 18 July - 7.6, 25 July - 7.45, 22 August - 7.30,

 

Deuteronomy 31.8 "The Lord Himself goes before you and will be with you; He will never leave you nor forsake you. Do not be afraid; do not be discouraged."

 

  • Author

Thanks for everyone's words, it means a lot. I guess I'm also disappointed as I thought I'd be further along than what I am, especially after such a short time on the drugs. I don't hear much about short term use and reactions.

Edited by Troy021079

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

56 minutes ago, Troy021079 said:

Thanks for everyone's words, it means a lot. I guess I'm also disappointed as I thought I'd be further along than what I am, especially after such a short time on the drugs. I don't hear much about short term use and reactions.

There are loads of us who used these drugs short term and are still having issues, even one pill. You are doing better than you think and given some more time I think you will be doing better still.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author
10 minutes ago, Chippy said:

There are loads of us who used these drugs short term and are still having issues, even one pill. You are doing better than you think and given some more time I think you will be doing better still.

Thanks @Chippy I guess it's my wave brain talking a bit. I know I've made good improvements, it just seems out of proportion the amount of time taking those **** drugs to the time it takes to heal 😬

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

5 minutes ago, Troy021079 said:

it just seems out of proportion the amount of time taking those **** drugs to the time it takes to heal 😬

Unfortunately often there is no correlation between the two.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Still in this wave after about 3 weeks 😢 some windows creep in but aren't holding like my last 5 week window. It really feels like it's come crashing down 🙁

Someone said I full under a kindling injury given my history of coming sertraline then back on the other ****** drugs. I don't fully understand what kindling is?

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

1 hour ago, Troy021079 said:

Still in this wave after about 3 weeks 😢 some windows creep in but aren't holding like my last 5 week window. It really feels like it's come crashing down 🙁

Someone said I full under a kindling injury given my history of coming sertraline then back on the other ****** drugs. I don't fully understand what kindling is?

Sorry to hear that youre still in a wave. Sending lots of support! From my understanding, kindling is when your nervous system has become sensitized by a drug and then adding further drugs sensitizes it more and more, making everything worse. So lets say for example youve been on sertraline. You taper off it with the doctor's instructions and you feel fine. Then later you go back on sertraline again and taper off again. all of a sudden you start getting bad withdrawal that you didint get the first time. I think that it also applies to start up symptoms.

Prior History:

(note that these are only the first prescription dates since i dont remember how long i was on them. there are also some prescriptions of the same stuff that were prescribed again at a later date so i dont remember if ive tried them again or not.)

Concerta: 18mg - 12.3.2014 ⏐ 36mg - 28.4.2014

Equasym Retard: 30mg - 20.11.2014

Medikinet: 5mg - 8.9.2015

Elvanse: 30mg - 30.10.2015

Risperdal: 0,5mg - 8.12.2015 ⏐ 1mg - 2.3.2017

Sertraline: 50mg - 14.10.2016 ⏐ 100mg - 17.1.2018

Intuniv: 1mg - 7.4.2017 ⏐ 2mg - 21.4.2017 ⏐ 4mg - 9.5.2017 ⏐ 3mg - 8.8.2017

Primperan: 10mg - 27.2.2019

Strattera: 25mg - 18.4.2019 ⏐ 10mg - 10.5.2019

Quetiapine: 25mg - 23.2.2021

Mirtazapine: 15mg - 29.2.2024


Escitalopram History:

9.9.2021 Escitalopram 10mg

9.9.2022 Escitalopram 15mg

2.5.2024 Escitalopram 20mg

1.7.2024 Escitalopram CT

11.11.2024 Escitalopram RI 10mg

14.11.2024 Escitalopram CT

15.12.2024 Escitalopram 2.5mg

29.12.2024 Escitalopram 5mg

12.1.2025 Escitalopram 10mg

12.1.2026 Escitalopram 7.5mg

26.1.2026 Escitalopram 5mg

 

Current Dose: Escitalopram 5mg

(some of these dates may not be entirely correct but theyre close enough based on what i can remember)

1 hour ago, Troy021079 said:

Still in this wave after about 3 weeks 😢 some windows creep in but aren't holding like my last 5 week window. It really feels like it's come crashing down 🙁

Sorry to read, this process can be so cruel, better days will come.

1 hour ago, Troy021079 said:

Someone said I full under a kindling injury given my history of coming sertraline then back on the other ****** drugs. I don't fully understand what kindling is?

The term comes from the alcohol community. I see it as literally as dry wood prepping for a bigger fire. So every move that is made, starting a drug, stopping a drug, adding in more drugs, increasing the dose, all adds more fuel or kindling to the fire and helps the flames grow bigger and bigger.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

49 minutes ago, Chippy said:

Sorry to read, this process can be so cruel, better days will come.

The term comes from the alcohol community. I see it as literally as dry wood prepping for a bigger fire. So every move that is made, starting a drug, stopping a drug, adding in more drugs, increasing the dose, all adds more fuel or kindling to the fire and helps the flames grow bigger and bigger.

What are your thoughts on the permanence of kindling? Is it reversible or do you think that once it happens, the sensitivity will be there for the rest of your life? let me know if i should move this question to my own thread!

Prior History:

(note that these are only the first prescription dates since i dont remember how long i was on them. there are also some prescriptions of the same stuff that were prescribed again at a later date so i dont remember if ive tried them again or not.)

Concerta: 18mg - 12.3.2014 ⏐ 36mg - 28.4.2014

Equasym Retard: 30mg - 20.11.2014

Medikinet: 5mg - 8.9.2015

Elvanse: 30mg - 30.10.2015

Risperdal: 0,5mg - 8.12.2015 ⏐ 1mg - 2.3.2017

Sertraline: 50mg - 14.10.2016 ⏐ 100mg - 17.1.2018

Intuniv: 1mg - 7.4.2017 ⏐ 2mg - 21.4.2017 ⏐ 4mg - 9.5.2017 ⏐ 3mg - 8.8.2017

Primperan: 10mg - 27.2.2019

Strattera: 25mg - 18.4.2019 ⏐ 10mg - 10.5.2019

Quetiapine: 25mg - 23.2.2021

Mirtazapine: 15mg - 29.2.2024


Escitalopram History:

9.9.2021 Escitalopram 10mg

9.9.2022 Escitalopram 15mg

2.5.2024 Escitalopram 20mg

1.7.2024 Escitalopram CT

11.11.2024 Escitalopram RI 10mg

14.11.2024 Escitalopram CT

15.12.2024 Escitalopram 2.5mg

29.12.2024 Escitalopram 5mg

12.1.2025 Escitalopram 10mg

12.1.2026 Escitalopram 7.5mg

26.1.2026 Escitalopram 5mg

 

Current Dose: Escitalopram 5mg

(some of these dates may not be entirely correct but theyre close enough based on what i can remember)

2 minutes ago, Some0n3 said:

What are your thoughts on the permanence of kindling? Is it reversible or do you think that once it happens, the sensitivity will be there for the rest of your life? let me know if i should move this question to my own thread!

I dont see it as a scary thing you catch just the description of continued nervous system sensitivity irritation. The body is strong and smart and designed to heal! :)

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

16 minutes ago, Chippy said:

I dont see it as a scary thing you catch just the description of continued nervous system sensitivity irritation. The body is strong and smart and designed to heal! :)

Thanks for the answer!

Prior History:

(note that these are only the first prescription dates since i dont remember how long i was on them. there are also some prescriptions of the same stuff that were prescribed again at a later date so i dont remember if ive tried them again or not.)

Concerta: 18mg - 12.3.2014 ⏐ 36mg - 28.4.2014

Equasym Retard: 30mg - 20.11.2014

Medikinet: 5mg - 8.9.2015

Elvanse: 30mg - 30.10.2015

Risperdal: 0,5mg - 8.12.2015 ⏐ 1mg - 2.3.2017

Sertraline: 50mg - 14.10.2016 ⏐ 100mg - 17.1.2018

Intuniv: 1mg - 7.4.2017 ⏐ 2mg - 21.4.2017 ⏐ 4mg - 9.5.2017 ⏐ 3mg - 8.8.2017

Primperan: 10mg - 27.2.2019

Strattera: 25mg - 18.4.2019 ⏐ 10mg - 10.5.2019

Quetiapine: 25mg - 23.2.2021

Mirtazapine: 15mg - 29.2.2024


Escitalopram History:

9.9.2021 Escitalopram 10mg

9.9.2022 Escitalopram 15mg

2.5.2024 Escitalopram 20mg

1.7.2024 Escitalopram CT

11.11.2024 Escitalopram RI 10mg

14.11.2024 Escitalopram CT

15.12.2024 Escitalopram 2.5mg

29.12.2024 Escitalopram 5mg

12.1.2025 Escitalopram 10mg

12.1.2026 Escitalopram 7.5mg

26.1.2026 Escitalopram 5mg

 

Current Dose: Escitalopram 5mg

(some of these dates may not be entirely correct but theyre close enough based on what i can remember)

  • Author
1 hour ago, Chippy said:

I dont see it as a scary thing you catch just the description of continued nervous system sensitivity irritation. The body is strong and smart and designed to heal! :)

I was told I would heal, it'll just take time if this is the case, this being from a prominent therapist who has been through withdrawal and helps a lot of people. When you're in a wave it sure feels like it's forever.

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

  • Author

Question. 5 week window with some symptoms but going well, back in the gym also going well, went in to wave about 3 weeks ago with some windows but I'm more reactive now to exercise and stress. Is this a normal Windows wave thing or could it be I've gone backwards as I'm not tolerating things I use to to a certain degree. Thanks in advance.

Edited by Troy021079
Typo

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

Sounds like a wave to me. What you want to avoid is falling into the trap of measuring your recovery in the short term. It takes place over months, and you’re doing better than you were months ago. That’s progress despite the waves that may come. Every time you move forward by challenging yourself, you’re bound to experience some reactivity. You’re really doing well!

Started Paxil for GAD in 1999

Unsuccessful taper attempt in 2006

Paxilprogress helped with a successful taper completed in 2009

Using therapy and CBT to manage my anxiety
 

I offer advice based on my experience.  Nothing I share is intended to be medical or therapy advice. 

  • Author
1 hour ago, mstimc60 said:

Sounds like a wave to me. What you want to avoid is falling into the trap of measuring your recovery in the short term. It takes place over months, and you’re doing better than you were months ago. That’s progress despite the waves that may come. Every time you move forward by challenging yourself, you’re bound to experience some reactivity. You’re really doing well!

Thanks @mstimc60 that's a good way of of putting it. I guess after that window (which wasn't perfect) it feels devastating being more sensitive and what feels like going backwards.

This wave feels a bit different, normally I'd get a wave, feel activated for 2 or 3 weeks and settle, this one is fluctuating all over the place. My normal gym routine has been toned down, stress is hitting a bit harder and morning anxiety has increased again etc 🤦 not the pattern I'm use to and if I'm honest, it does scare you a bit.

Edited by Troy021079
Mistakes

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

6 hours ago, Troy021079 said:

This wave feels a bit different, normally I'd get a wave, feel activated for 2 or 3 weeks and settle, this one is fluctuating all over the place. My normal gym routine has been toned down, stress is hitting a bit harder and morning anxiety has increased again etc 🤦 not the pattern I'm use to and if I'm honest, it does scare you a bit.

Hey @Troy021079, it's totally normal for waves to feel different from one another. I don't think patterns last long in WD to be honest. Often we think we've found a pattern and it lasts for a little while, but then it changes or disappears. WD is so unpredictable for all of us, but what we do know is that the waves will lift and relief will come again.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author
14 hours ago, SarahMc said:

Hey @Troy021079, it's totally normal for waves to feel different from one another. I don't think patterns last long in WD to be honest. Often we think we've found a pattern and it lasts for a little while, but then it changes or disappears. WD is so unpredictable for all of us, but what we do know is that the waves will lift and relief will come again.

This wave is kicking my ass, I can't even do a light workout without it escalatiing, it's fluctuating up and down with adrenaline surges, worst one I've had in a while 😔

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

  • Author

I have had more anger and frustration kicking in lately also, I'm ready to move forward but being held back by an uncooperative cns.

Pristiq for 7 days had a bad reaction. 

Quetiapine 7 days which sensitised me further. 

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