7 hours ago, Saar8srl said:

Update; Mark Horowitz told me to updose. Its now 1 month on 3 mg. He told me watch the symptoms and slowly updose until I feel some how fine. I don’t know if I’m doing the right thing. He thinks it will help me because I had relief from the 10 mg earlier.

Thanks for the update. It is great you spoke with Dr. H again.

On 9/13/2026 at 6:50 AM, Saar8srl said:

Hi ,

Increased to 4 mg yesterday but had an active reaction so went back today to 3mg. Will I be ok? I feel so odd and disconnect from live. Had a few days last week when I felt relief. Can someone tell me if I’m doing the right thing. Feels like this is my life now in bed most of the time . Will I ever stabilize? Mark also doesn’t know what to say. He just told ne to increase because the last Ri did me good but that also could be a “honeymoon period”. So he told me I could gradually do up. But it’s a risk. I don’t know what to do anymore. Has anyone have experience with Ri and how to handle this situation? I’m going to hold now for a while on 3mg. Anyone who can help wirh experience?

Just wanted to highlight this post for you where you felt 4mg was activating.

If you choose to increase your dose I would personally be cautious at first because of this reaction here.

Let us know what you decide to do and how you get on. Thinking of you xxx

Chippy

18 minutes ago, Chippy said:

Let us know what you decide to do and how you get on. Thinking of you xxx

Thank you chippy. When will you notice a bad reaction? Did you ever saw someone getting better eventually by updosing slowly?

12 minutes ago, Saar8srl said:

Thank you chippy. When will you notice a bad reaction? Did you ever saw someone getting better eventually by updosing slowly?

We always suggest not jumping doses around. But if the reaction is severe return to the previous dose. Otherwise hold the dose for 7-10 days. Sometimes thing can get a little worse. This could be just what happens as you increase but could be waves and windows playing out anyway.

People definitely can benefit from updosing after ri. We pretty much always have people on an initial entry dose after ri and then slowly ease it up. Much safer approach.

8 hours ago, Saar8srl said:

The only thing I know is that I was functional after the 10 mg and my mood was better. I’m scared and the way I’m living the past few months are very hard. Bedridden and not able to function. I know there are people who Ri and could somehow function. I hope firing the right thing

My dear neighbor, I hope you are doing well.

I don't know how I can help you, but I want to say that my own life has been completely on hold for 14 months.

The waves are incredibly difficult.

Please try not to push yourself too hard. You are not alone.

We will all get through this crisis together."

8 minutes ago, lost4ever said:

dear neighbor, I hope you are doing well.

I don't know how I can help you, but I want to say that my own life has been completely on hold for 14 months.

The waves are incredibly difficult.

Please try not to push yourself too hard. You are not alone.

❤️❤️❤️thank you dear. I send you much love and blessings

Hi @Saar8srl ,

Why did you CT in may after being on 10mg?

1 minute ago, Sophia said:

Why did you CT in may after being on 10mg?

I didn’t . Al the choices where my doctors. In the hospital I was very bad. Nobody believe me and they didn’t want to spend time on baby doses and stopped my medication.

Oh sorry! :(

I thought Mark might have been referring to that 10mg ?

Thinking of you @Saar8srl. I'm just going to briefly summarize our chat from the dm's here so that everyone's aware of what's going on and the advice that has been given.

You met with Dr. Horowitz again recently and he recommended that you continue up-dosing slowly. We talked about how you did briefly feel better on 10 mg in the hospital back in May, but you also had a minor activating reaction when you recently tried to go up to 4 mg.

I said that there probably won’t be a solution that will fix everything, besides lots of time as we always say. Up-dosing could help if you felt better previously on a higher dose, but often we can’t recreate how we felt previously just by going back to a particular dose because our nervous systems are so sensitive now. So there’s always a risk.

I recommended that if you do want to try up-dosing again to go slowly, like try 4 mg again for a week and see how things go.

Please let us know what you decide 💜

On 10/4/2026 at 6:23 PM, Chippy said:

People definitely can benefit from updosing after ri. We pretty much always have people on an initial entry dose after ri and then slowly ease it up. Much safer approach.

Hi, would you say I’m 4 months in wd? I don’t know how to count. I guess my last injury? That was in may. Does this mean I’m still in an acute state? X

11 minutes ago, Saar8srl said:

Hi, would you say I’m 4 months in wd? I don’t know how to count. I guess my last injury? That was in may. Does this mean I’m still in an acute state? X

Hey. How are you? Did you increase your dose.

I wouldn’t worry about your timeline too much and what phase you are or are not in. Just one day at a time. Xxxx

42 minutes ago, Chippy said:

Hey. How are you? Did you increase your dose.

Hi, thanks chippy I’m not fine . Severe depression and anhedonia at this point. I did . Just don’t know if it helps. Don’t think so. I did it on 4 th of October. I think my body is not feeling it anymore.

20 minutes ago, Saar8srl said:

Hi, thanks chippy I’m not fine .

I am sorry to hear wish you could get some relief.

21 minutes ago, Saar8srl said:

I did . Just don’t know if it helps. Don’t think so. I did it on 4 th of October. I think my body is not feeling it anymore.

It’s good it didn’t make it worse. Did you notice the activation you had before at 4mg? I’d not increase anymore for a good week and then see how you are.

2 minutes ago, Chippy said:

It’s good it didn’t make it worse. Did you notice the activation you had before at 4mg? I’d not increase anymore for a good week and then see how you

No until now nothing but maybe it will come after 5 days when it reaches my blood?

2 minutes ago, Saar8srl said:

No until now nothing but maybe it will come after 5 days when it reaches my blood?

It’s good things are not worse immediately so I’d concentrate on that, so giving it time will allow you tell the effect. Maybe it will be nothing. Perhaps you’ll feel a bit easier. Then you can choose. Continue to increase or not.

7 minutes ago, Chippy said:

It’s good things are not worse immediately so I’d concentrate on that, so giving it time will allow you tell the effect. Maybe it will be nothing. Perhaps you’ll feel a bit easier. Then you can choose.

The question is do I help my brain heal with a small Ri or does it just do nothing. I dint know that yet. I have to wait and see what the 4 mg is doing . If the depression and my mood will get a little better I will be glad . Since I updose I see more windows tbh . But I don’t know is this is the Ri or the time . The depression is at least not so deep and the DPDR is a little less. But it’s just hard to say because I’m mostly in a wave and I don’t trust myself in a wave …

Also my mood and depression are changing literally every day. Before the Ri they were most the time present and now it’s different everyday and sometimes even during the day

21 minutes ago, Saar8srl said:

The question is do I help my brain heal with a small Ri or does it just do nothing. I dint know that yet. I have to wait and see what the 4 mg is doing . If the depression and my mood will get a little better I will be glad . Since I updose I see more windows tbh . But I don’t know is this is the Ri or the time . The depression is at least not so deep and the DPDR is a little less. But it’s just hard to say because I’m mostly in a wave and I don’t trust myself in a wave …

It’s why if you choose to make changes I would make small ones and observe. So many moving parts.

Update so far; helpful for myself and maybe others

I count may as my last injury. Although i had some oxazepam when i was hospitalized in may and June.

4 months off since wd.

Symptoms before RI;

-uncontrollable Crying spells

-heart pounding in the morning

-Body shivering in the morning

-instructive thoughts

-severe DPDR

-severe depression

-severe head burning

-head pressure ( forehead)

-emotional bluntness

-couldn’t recognize my own house

-anhedonia

-can’t listen and have a conversation probably

-can’t watch tv and read and send texts

-can’t do simpel tasks

Symptoms after the RI

-anhedonia

-can’t watch tv and read

- less DPDR

-less severe depression

-instructive thoughts

-head pressure ( forehead) only when I’m blunted and I’m not all the time

-I still have trouble to recognize my house because I used to be happy and functional here.

-can’t do simpel tasks but maybe 5% better.

Slowly updose Zoloft to get to the point where I could function

Edited October 6Oct 6 by Saar8srl

18 minutes ago, Saar8srl said:

Also my mood and depression are changing literally every day. Before the Ri they were most the time present and now it’s different everyday and sometimes even during the day

This is a great sign. Please give us this kinda detail. It’s really important.

Just now, Chippy said:

This is a great sign. Please give us this kinda detail. It’s really important

Really?❤️❤️❤️

1 minute ago, Saar8srl said:

can’t do simpel tasks but maybe 5% better.

This is very good news.

Just now, Saar8srl said:

Really?❤️❤️❤️

100%

3 minutes ago, Chippy said:

100%

You made me cry 🙏❤️

2 minutes ago, Saar8srl said:

You made me cry 🙏❤️

You should tell us how things are going. All the good bits not just the bad. The good bits give an indication of improvement. The fluctuations are signs something is changing. This could be ri helping. To can take many weeks to show its full colours. So long as you don’t get lots worse it’s ok to increase the dose. Just carefully. No panic. Like you said. Waves make you not make good choices potentially.

Maybe do a daily diary. Just a little how you were that day with the good and the bad in a time order. You may have seen others do it