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Marina: on/off/on/off Zoloft since end of 2020

Featured Replies

  • Author

Thank you @namastejen1

It's somewhat hyperbolic at this point. I mostly follow my "instinct" in tapering to put it that way.

I have faith, am Catholic (but lately also leaning towards Eastern Orthodox). But sadly, as I went into withdrawal I feel like I've been cut away from everything - the world, myself and God.

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

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  • Marina
    Marina

    Thank you @SarahMc ❤️ So far the day isn't terrible, hopefully it will continue that way until bedtime. 🙏🏻 I hope you feel some relief as the day goes by. ❤️

  • Marina
    Marina

    Update - 8 and a half months: Many times I wanted to write an update but it was too hard for me to be on here. It was hard on the bad days because I didn't want to sob and complain too much and on t

  • Marina
    Marina

    Thank you @SarahMc and @Fullhealing ❤️ And again, thank you @Chippy and @Luke ❤️ Your comments and encouragement mean more than you know. Yesterday I was so low, but already today after reading what

  • Author

Thank you @Tracey

 

I also feel that I have situational depression on top of the chemical one and that is making things worse.

 

I have my boyfriend as the main support. Family, some friends... But I don't see them all too often and I think that "isolation" affects me. I am usually an introvert but since this withdrawal started I almost constantly need people around be (but also don't want to be clingy).

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

  • Author

Update (cca 4 and a half months in)

 

I've been in a window since Sunday. It's amazing how normal I feel these last few days. WD almost feels like a distant flashback or a bad dream. (It's a bit of a dangerous game forgetting you're in WD, especially when you're suddenly hit by derealisation. 😵‍💫)
Physical symptoms are still here, but mentally I am so close to my usual self. I am particularly enjoying music in this window, which wasn't really possible most days since it all started. (Not all music! Some music still disturbs me.) I've been listening to a lot of music, singing to it and even did a bit of a dance at home. So shocking!

 

I assume this window will end very soon as my period is approaching. Maybe a very bad wave is waiting for me or it will seem worse after feeling so good after a long time.
But it's good to know windows exist. I had to write it down while still in a window, as I tend to forget anything good ever existed when I'm in a wave. 

 

(I wrote this yesterday evening. Today is another gloomy day and I feel like I'm entering a wave. Weather affects me so much.)

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

4 minutes ago, Marina said:

Update (cca 4 and a half months in)

 

I've been in a window since Sunday. It's amazing how normal I feel these last few days. WD almost feels like a distant flashback or a bad dream. (It's a bit of a dangerous game forgetting you're in WD, especially when you're suddenly hit by derealisation. 😵‍💫)
Physical symptoms are still here, but mentally I am so close to my usual self. I am particularly enjoying music in this window, which wasn't really possible most days since it all started. (Not all music! Some music still disturbs me.) I've been listening to a lot of music, singing to it and even did a bit of a dance at home. So shocking!

 

I assume this window will end very soon as my period is approaching. Maybe a very bad wave is waiting for me or it will seem worse after feeling so good after a long time.
But it's good to know windows exist. I had to write it down while still in a window, as I tend to forget anything good ever existed when I'm in a wave. 

 

(I wrote this yesterday evening. Today is another gloomy day and I feel like I'm entering a wave. Weather affects me so much.)

Hey Marina

 

Thank you for the update.

 

This is great news! So happy you had a nice window. Look at all you could do whilst in it! It night and day isn't it. 🙂 

 

Its great to take note as you say, then when you're not having such a good day you can remember that better days are there.

 

Im sorry to also read you are not having such a good day today, and yes many of us are affected by the grey winter days. More light is coming now. Spring will be here before we know it.

 

Chippy

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Thank you, Chippy 🙂

 

The day just started. We'll see how it goes, but I am definitely feeling the decrease in mood. I am going to a harp and flute concert tonight, so I have something to look forward to.

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

4 minutes ago, Marina said:

Thank you, Chippy 🙂

 

The day just started. We'll see how it goes, but I am definitely feeling the decrease in mood. I am going to a harp and flute concert tonight, so I have something to look forward to.

That's it Marina, early yet.

 

That's good. Sometime nice to look forward to 🙂 

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

@MarinaHi Marina. I thought I would stop by and say hello. I noticed that you are using liquid Zoloft. That is how I had to do it as I got down to the small numbers. It worked well for me and I hope it works as well for you.  Warm wishes. R.

I am not a health professional in any way, and I do not give medical advice. These are only my opinions. Any decisions about your medical care should be discussed with a qualified medical professional.

 

If you would like to reach me, please post on my thread and tag @rachelsusan, or post on your thread and tag in the same way, so I will see it. 😀😀😀

HISTORY FOR GABAPENTIN TAPER

April 18, 2026: 200 mg to 195 mg (2.5% reduction), May 18, 2026: 195 mg to 187.5 mg (3.85% reduction), June 28, 2026: 187.5 mg to 185 mg (1.33% reduction)

 

HISTORY FOR ZOLOFT TAPER

Feb. 2016 to June 2016  - Was on 150mg Zoloft.  

Quit Zoloft (Sertraline) June  2016,  reinstated 50mg of Zoloft July 2016.  From July 2016  to October 2016 went from 50 mg down 2.3 mg. I up-dosed in November 2016 to 12.5 mg. Held there until January 2017 when I started a much slower taper.

STARTING SENSIBLE  ZOLOFT TAPERING USING GUIDELINES FROM ANOTHER SITE - WHICH WAS VERY HELPFUL

Dec. 10 2016  - switched to Liquid Zoloft (Sertraline) @ 12.5 mg.   Jan. 4, 2020 1.875 mg (6.3%). Jan. 25, 2020 1.75 mgFeb. 29, 2020 1.625mg (7.10%).  Apr. 4, 2020 1.5 mg.  May 9, 2020 1.375 mg.  June 6, 2020 1.25 mg. (9.10%).  July 4, 2020 1.125 mg. (10%).  August 15, 2020 1.0 mg.  Oct 24, 2020 .875 mg.  Nov. 28, 2020 .75mgJan 16, 2021 .685mg (8.7%).  Feb 13, 2021 .62mg. March 12, 2021 .56mg.  May 1, 2021 .375mg.  May 29, 2021 .25mg. June 26, 2021 .125mg. July 25, 2021 .065mg. August 22, 2021 .048mg.  October 2, 2021 .043mg.  October 10, 2021 .038mg.  October 23, 2021 .035mg.  October 30, 2021 .032mg.  Nov. 13, 2021 .030 mg.  Dec 4, 2021 .0285 mg.  Dec 11, 2021 .0265 mg. Dec 18, 2021 .0246 mg. Dec 25, 2021 .023mg. Jan 1, 2022. 0 mg. OFF COMPLETELY

My thread at SA - https://www.survivingantidepressants.org/forums/topic/12649-☼-rachelsusan-zoloft-on-off-and-reinstated/page/28/

Started my Gabapentin reduction. Transitioned to partial liquid, 100mg in liquid and a 100mg capsule for a total of a 200mg dose. Dose three times a day for a total of 600mg a day. April 18 2026 first cut to 195mg (2.5%). May 18, 2026 to 187.5 (3.85%), June 28, 2026 to 185 (1.33%).

  • Author

Thank you @RachelSusan

I only wish I knew local pharmacies made it and switched to liquid sooner, maybe I would have avoided the "break" in my taper that happened with compounded capsules and which started my whole withdrawal fun. 🥲

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

On 1/19/2026 at 2:58 AM, Marina said:

Thank you @namastejen1

It's somewhat hyperbolic at this point. I mostly follow my "instinct" in tapering to put it that way.

I have faith, am Catholic (but lately also leaning towards Eastern Orthodox). But sadly, as I went into withdrawal I feel like I've been cut away from everything - the world, myself and God.

I can understand that...the body, mind, heart, and spirit can get disconnected when we are going through illness or this terrible withdrawal/Rx drugged process. Press on with prayer or mass--whatever has helped in the past. I like getting Communion at mass--I typically feel better afterwards if I focus on the process and not just go up in line, rotely take it, and sit down again. Those 2 are very close siblings--so you're not making too much of a switch there and can find a lot of overlap.

 

I have been off of the site for a few days with a lot going on with the Monday being a holiday, busy weekend prior, and work. So I apologize if I am repeating what others have said, but I would do my best to remain consistent with the taper--1 month, hyperbolic. Our body, and brain in particular, like homeostasis and regularity especially with mind-altering drugs. I know you will make the right decision for yourself though. Hopefully you are having a great day or it will become better. Take care.

2 Tim 1:7 For God did not give us a spirit of cowardice (fear); but rather of power and love and self-control (a sound mind).

The Whole Story About Me

--Current Rx: since 2000-2025 Levothyroxine discontinued late Sept 2025 under DO supervision--no menstrual cycle for 2 months, Hypothalamus PMG brought it back and has been regular ever since under functional chiropractor =o) thank God for holistic medicine

2017-current Remeron/Mirt. recent taper schedule here: crushed pills 0.45mg May 30, 2025; 0.4mg Sept 14, 2025; found out 0.4mg weighed is actually a dose of 0.44mg Dec 19, 2025 and now using compounded Rx; 0.41mg Feb 27, 2026; 0.39mg April 3, 2026, 0.38mg May 8, 2026, 0.37mg June 28, 2026.

--Supplements: Standard Process-Whole Food Folate, Prolamine Iodine Plus, B Vitality w/ CoQ10, Zypan, RNA, Cataplex E, Symplex F, and Immuplex (sort of like a multi but for Oct-Apr) when needed; Biotics Research- Mg-Zyme 100mg; Omega-3 Oil, Black Currant Seed Oil, Vitamin D3/K2 drops; sometimes Seeking Health methyl free multi vitamin and elderberry zinc gummies

**Love my work, fitness, polyvagal exercises (includes yoga-style poses for nervous system regulation), prayer/Inner Healing Prayer, holistic health, somatic therapies, lovingkindness, forest therapy, singing, helping others, spending time in nature and with family and friends.

Anti-histamine Withdrawal Video-Explains a lot (This is not me.)

  • Author

Thank you @namastejen1

 

I go to mass but I don't take communion. I can't go to confession because I live in a relationship outside of marriage. 😔

 

I would say I have been feeling a bit better lately. I'll probably start tapering again tomorrow but I'll listen to my body. Nothing too much, nothing too fast.

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

Well, I would still go to Communion--I know that is not the way, but you are invited to a "party" and should partake of it--a dear priest said that many years ago when I was kid living in Chicago. Maybe our priests were a bit liberal but they wanted everyone to partake of the life giving part of Communion. It's up to you. Must leave the site for now for work. Message with you here later.

2 Tim 1:7 For God did not give us a spirit of cowardice (fear); but rather of power and love and self-control (a sound mind).

The Whole Story About Me

--Current Rx: since 2000-2025 Levothyroxine discontinued late Sept 2025 under DO supervision--no menstrual cycle for 2 months, Hypothalamus PMG brought it back and has been regular ever since under functional chiropractor =o) thank God for holistic medicine

2017-current Remeron/Mirt. recent taper schedule here: crushed pills 0.45mg May 30, 2025; 0.4mg Sept 14, 2025; found out 0.4mg weighed is actually a dose of 0.44mg Dec 19, 2025 and now using compounded Rx; 0.41mg Feb 27, 2026; 0.39mg April 3, 2026, 0.38mg May 8, 2026, 0.37mg June 28, 2026.

--Supplements: Standard Process-Whole Food Folate, Prolamine Iodine Plus, B Vitality w/ CoQ10, Zypan, RNA, Cataplex E, Symplex F, and Immuplex (sort of like a multi but for Oct-Apr) when needed; Biotics Research- Mg-Zyme 100mg; Omega-3 Oil, Black Currant Seed Oil, Vitamin D3/K2 drops; sometimes Seeking Health methyl free multi vitamin and elderberry zinc gummies

**Love my work, fitness, polyvagal exercises (includes yoga-style poses for nervous system regulation), prayer/Inner Healing Prayer, holistic health, somatic therapies, lovingkindness, forest therapy, singing, helping others, spending time in nature and with family and friends.

Anti-histamine Withdrawal Video-Explains a lot (This is not me.)

  • Author

@namastejen1

Maybe a kid has much less sins than me. 😅 I have commited so many sins since my last confession. It has been close to 20 years, maybe even more... I wouldn't feel right taking communion.

 

No worries. Have a nice day. 😊

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

@Marina In reply to your comment about wishing you had known about liquid sooner, you and me both. I actually wish I had known a lot of things sooner when it comes to Zoloft. I was glad to read in your last post that you are feeling a bit better. One thing I learned while tapering was that I had to wait much longer between cuts than was even recommended. It sounds like you are really listening to your body, which is a good way to guide yourself through this.

I am not a health professional in any way, and I do not give medical advice. These are only my opinions. Any decisions about your medical care should be discussed with a qualified medical professional.

 

If you would like to reach me, please post on my thread and tag @rachelsusan, or post on your thread and tag in the same way, so I will see it. 😀😀😀

HISTORY FOR GABAPENTIN TAPER

April 18, 2026: 200 mg to 195 mg (2.5% reduction), May 18, 2026: 195 mg to 187.5 mg (3.85% reduction), June 28, 2026: 187.5 mg to 185 mg (1.33% reduction)

 

HISTORY FOR ZOLOFT TAPER

Feb. 2016 to June 2016  - Was on 150mg Zoloft.  

Quit Zoloft (Sertraline) June  2016,  reinstated 50mg of Zoloft July 2016.  From July 2016  to October 2016 went from 50 mg down 2.3 mg. I up-dosed in November 2016 to 12.5 mg. Held there until January 2017 when I started a much slower taper.

STARTING SENSIBLE  ZOLOFT TAPERING USING GUIDELINES FROM ANOTHER SITE - WHICH WAS VERY HELPFUL

Dec. 10 2016  - switched to Liquid Zoloft (Sertraline) @ 12.5 mg.   Jan. 4, 2020 1.875 mg (6.3%). Jan. 25, 2020 1.75 mgFeb. 29, 2020 1.625mg (7.10%).  Apr. 4, 2020 1.5 mg.  May 9, 2020 1.375 mg.  June 6, 2020 1.25 mg. (9.10%).  July 4, 2020 1.125 mg. (10%).  August 15, 2020 1.0 mg.  Oct 24, 2020 .875 mg.  Nov. 28, 2020 .75mgJan 16, 2021 .685mg (8.7%).  Feb 13, 2021 .62mg. March 12, 2021 .56mg.  May 1, 2021 .375mg.  May 29, 2021 .25mg. June 26, 2021 .125mg. July 25, 2021 .065mg. August 22, 2021 .048mg.  October 2, 2021 .043mg.  October 10, 2021 .038mg.  October 23, 2021 .035mg.  October 30, 2021 .032mg.  Nov. 13, 2021 .030 mg.  Dec 4, 2021 .0285 mg.  Dec 11, 2021 .0265 mg. Dec 18, 2021 .0246 mg. Dec 25, 2021 .023mg. Jan 1, 2022. 0 mg. OFF COMPLETELY

My thread at SA - https://www.survivingantidepressants.org/forums/topic/12649-☼-rachelsusan-zoloft-on-off-and-reinstated/page/28/

Started my Gabapentin reduction. Transitioned to partial liquid, 100mg in liquid and a 100mg capsule for a total of a 200mg dose. Dose three times a day for a total of 600mg a day. April 18 2026 first cut to 195mg (2.5%). May 18, 2026 to 187.5 (3.85%), June 28, 2026 to 185 (1.33%).

  • Author

@RachelSusan Oh, yes... If I had known what hell awaits me because of these drugs, I would never had touched them. But they all said it was "mild", "safe" and no problem to come off of.

 

My window has closed and "fun" begins again, sadly...

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

@Marina Ouch. I was just looking at your list of symptoms. They are all bad. I kept a list as well.

I am not a health professional in any way, and I do not give medical advice. These are only my opinions. Any decisions about your medical care should be discussed with a qualified medical professional.

 

If you would like to reach me, please post on my thread and tag @rachelsusan, or post on your thread and tag in the same way, so I will see it. 😀😀😀

HISTORY FOR GABAPENTIN TAPER

April 18, 2026: 200 mg to 195 mg (2.5% reduction), May 18, 2026: 195 mg to 187.5 mg (3.85% reduction), June 28, 2026: 187.5 mg to 185 mg (1.33% reduction)

 

HISTORY FOR ZOLOFT TAPER

Feb. 2016 to June 2016  - Was on 150mg Zoloft.  

Quit Zoloft (Sertraline) June  2016,  reinstated 50mg of Zoloft July 2016.  From July 2016  to October 2016 went from 50 mg down 2.3 mg. I up-dosed in November 2016 to 12.5 mg. Held there until January 2017 when I started a much slower taper.

STARTING SENSIBLE  ZOLOFT TAPERING USING GUIDELINES FROM ANOTHER SITE - WHICH WAS VERY HELPFUL

Dec. 10 2016  - switched to Liquid Zoloft (Sertraline) @ 12.5 mg.   Jan. 4, 2020 1.875 mg (6.3%). Jan. 25, 2020 1.75 mgFeb. 29, 2020 1.625mg (7.10%).  Apr. 4, 2020 1.5 mg.  May 9, 2020 1.375 mg.  June 6, 2020 1.25 mg. (9.10%).  July 4, 2020 1.125 mg. (10%).  August 15, 2020 1.0 mg.  Oct 24, 2020 .875 mg.  Nov. 28, 2020 .75mgJan 16, 2021 .685mg (8.7%).  Feb 13, 2021 .62mg. March 12, 2021 .56mg.  May 1, 2021 .375mg.  May 29, 2021 .25mg. June 26, 2021 .125mg. July 25, 2021 .065mg. August 22, 2021 .048mg.  October 2, 2021 .043mg.  October 10, 2021 .038mg.  October 23, 2021 .035mg.  October 30, 2021 .032mg.  Nov. 13, 2021 .030 mg.  Dec 4, 2021 .0285 mg.  Dec 11, 2021 .0265 mg. Dec 18, 2021 .0246 mg. Dec 25, 2021 .023mg. Jan 1, 2022. 0 mg. OFF COMPLETELY

My thread at SA - https://www.survivingantidepressants.org/forums/topic/12649-☼-rachelsusan-zoloft-on-off-and-reinstated/page/28/

Started my Gabapentin reduction. Transitioned to partial liquid, 100mg in liquid and a 100mg capsule for a total of a 200mg dose. Dose three times a day for a total of 600mg a day. April 18 2026 first cut to 195mg (2.5%). May 18, 2026 to 187.5 (3.85%), June 28, 2026 to 185 (1.33%).

  • Author

@RachelSusan Can you give a current update on your recovery/symptoms?

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

On 1/21/2026 at 10:14 AM, Marina said:

@namastejen1

Maybe a kid has much less sins than me. 😅 I have commited so many sins since my last confession. It has been close to 20 years, maybe even more... I wouldn't feel right taking communion.

 

No worries. Have a nice day. 😊

Well, do what you think is best...I feel our priests are super compassionate, maybe I have been blessed recently with nonjudgmental ones. There is one like this that I keep good boundaries around, though, who was reassigned with the shortage. I think you would feel better just letting it all out in a face to face scenario. I am only encouraging not pushing--at least that is my intention here. We all commit sins or do wrongs--none of us is perfect. It was 30 years since I had gone to confession when I finally went back. I have a few more bigger sins to discuss but like going to a neighboring church or the monks that are in a religious order away from the diocesan churches. Too much singing and chatting with our current priest that they know my voice, so no anonymity there!

 

But hopefully you are faring well. I know it takes longer than what we would like through this circus of Rx. We will both get there to 0mg soon. Just give it the necessary time you need. I hope by the end of 2027 to be free of this Mirt.

 

Have a great evening and stay warm. It feels -14 F over here right now. Hopefully it's nicer by you!

2 Tim 1:7 For God did not give us a spirit of cowardice (fear); but rather of power and love and self-control (a sound mind).

The Whole Story About Me

--Current Rx: since 2000-2025 Levothyroxine discontinued late Sept 2025 under DO supervision--no menstrual cycle for 2 months, Hypothalamus PMG brought it back and has been regular ever since under functional chiropractor =o) thank God for holistic medicine

2017-current Remeron/Mirt. recent taper schedule here: crushed pills 0.45mg May 30, 2025; 0.4mg Sept 14, 2025; found out 0.4mg weighed is actually a dose of 0.44mg Dec 19, 2025 and now using compounded Rx; 0.41mg Feb 27, 2026; 0.39mg April 3, 2026, 0.38mg May 8, 2026, 0.37mg June 28, 2026.

--Supplements: Standard Process-Whole Food Folate, Prolamine Iodine Plus, B Vitality w/ CoQ10, Zypan, RNA, Cataplex E, Symplex F, and Immuplex (sort of like a multi but for Oct-Apr) when needed; Biotics Research- Mg-Zyme 100mg; Omega-3 Oil, Black Currant Seed Oil, Vitamin D3/K2 drops; sometimes Seeking Health methyl free multi vitamin and elderberry zinc gummies

**Love my work, fitness, polyvagal exercises (includes yoga-style poses for nervous system regulation), prayer/Inner Healing Prayer, holistic health, somatic therapies, lovingkindness, forest therapy, singing, helping others, spending time in nature and with family and friends.

Anti-histamine Withdrawal Video-Explains a lot (This is not me.)

  • Author

@namastejen1 Thank you ❤️

 

I was thinking about just talking to a priest, first and foremost... Perhaps, about this WD situation if nothing else...

 

I am moving towards 0,1mg in my taper. Just tired of it...

 

It's not that cold here but it's terribly gloomy. Just clouds every single day. Everything is gray. Which is definitely not helping me in this situation. As if it's making my derealization even worse, just feeling stuck in a scary grey day all the time. 

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

It may help to talk things out--whatever feels best to you to bring up. I had a priest do a blessing over me, he was one to do this with a lot of people. He is filled different charismatic gifts of the Holy Spirit and is really someone who wants to share them in a very humble way. So perhaps a priest can do prayers with you. Some do them in different ways, of course.

Adoration has been helpful for me to just sit with Jesus in the form of His Eucharistic body. The silence, stillness, and sacredness is a gift.

A very new thing I enjoy is the liturgy of the hours; it has sung or read aloud songs (hymns and psalms), prayers, and other Scripture passages for free on the divine office website. Do whatever prayer when you can sort of thing, not a pressured/have to do it. The Compline or night time prayers are so nice to end the day with. Many start with those.

I am not sure where you are at now that you are dropping to 0.1mg. Please go slow for your brain and body. Time will go by anyway, best to be comfortable in this whole process by going low and slow with our drop downs--hyperbolic seems to be the way to go. 

Be well my friend.

2 Tim 1:7 For God did not give us a spirit of cowardice (fear); but rather of power and love and self-control (a sound mind).

The Whole Story About Me

--Current Rx: since 2000-2025 Levothyroxine discontinued late Sept 2025 under DO supervision--no menstrual cycle for 2 months, Hypothalamus PMG brought it back and has been regular ever since under functional chiropractor =o) thank God for holistic medicine

2017-current Remeron/Mirt. recent taper schedule here: crushed pills 0.45mg May 30, 2025; 0.4mg Sept 14, 2025; found out 0.4mg weighed is actually a dose of 0.44mg Dec 19, 2025 and now using compounded Rx; 0.41mg Feb 27, 2026; 0.39mg April 3, 2026, 0.38mg May 8, 2026, 0.37mg June 28, 2026.

--Supplements: Standard Process-Whole Food Folate, Prolamine Iodine Plus, B Vitality w/ CoQ10, Zypan, RNA, Cataplex E, Symplex F, and Immuplex (sort of like a multi but for Oct-Apr) when needed; Biotics Research- Mg-Zyme 100mg; Omega-3 Oil, Black Currant Seed Oil, Vitamin D3/K2 drops; sometimes Seeking Health methyl free multi vitamin and elderberry zinc gummies

**Love my work, fitness, polyvagal exercises (includes yoga-style poses for nervous system regulation), prayer/Inner Healing Prayer, holistic health, somatic therapies, lovingkindness, forest therapy, singing, helping others, spending time in nature and with family and friends.

Anti-histamine Withdrawal Video-Explains a lot (This is not me.)

  • 2 weeks later...

Hi Marina🙋🏻‍♀️how have you been? I wanted to check in on you. It’s nearly morning/time to wake up by you, where it’s almost bedtime for me. So I hope you have a nice Sunday. 😇

2 Tim 1:7 For God did not give us a spirit of cowardice (fear); but rather of power and love and self-control (a sound mind).

The Whole Story About Me

--Current Rx: since 2000-2025 Levothyroxine discontinued late Sept 2025 under DO supervision--no menstrual cycle for 2 months, Hypothalamus PMG brought it back and has been regular ever since under functional chiropractor =o) thank God for holistic medicine

2017-current Remeron/Mirt. recent taper schedule here: crushed pills 0.45mg May 30, 2025; 0.4mg Sept 14, 2025; found out 0.4mg weighed is actually a dose of 0.44mg Dec 19, 2025 and now using compounded Rx; 0.41mg Feb 27, 2026; 0.39mg April 3, 2026, 0.38mg May 8, 2026, 0.37mg June 28, 2026.

--Supplements: Standard Process-Whole Food Folate, Prolamine Iodine Plus, B Vitality w/ CoQ10, Zypan, RNA, Cataplex E, Symplex F, and Immuplex (sort of like a multi but for Oct-Apr) when needed; Biotics Research- Mg-Zyme 100mg; Omega-3 Oil, Black Currant Seed Oil, Vitamin D3/K2 drops; sometimes Seeking Health methyl free multi vitamin and elderberry zinc gummies

**Love my work, fitness, polyvagal exercises (includes yoga-style poses for nervous system regulation), prayer/Inner Healing Prayer, holistic health, somatic therapies, lovingkindness, forest therapy, singing, helping others, spending time in nature and with family and friends.

Anti-histamine Withdrawal Video-Explains a lot (This is not me.)

Hi @Marina,

 

I am wondering how you are doing? 

 

Hoping your are not in too much struggle. 💛

Aug 2006 - Sertraline 25/50/75/100mg TO June 2019 - Reduced from 100mg to 50mg over a few months

Sept  2019 - Reduced from 50mg to 25mg lasted a week,  then went back up to 50mg, after a few weeks back up to 100mg.

Oct 2021 - Reduced to 75mg, Dec 2021 (mid) reduced to 50mg , March 2022 - Reduced to 25mg

Oct 2022 - Reduce to 0mg (Immediate withdrawal crying, mood unstable, impending doom, digestive probs, tingling,numbness,burning, brain zaps,  insomnia)

Feb 2023 -  "Panic attack" lasting 14 hours, 2 weeks later start back on 25mg sertraline, 12 hours later severe 'panic attack' with chest pain, tachycardia, restlessness, hyponatraemia, impending doom, racing thoughts, akathisia mild.  Taken to emergency. 

March 2023 back up to 50mg (on medical advice), April 75mg, May 100mg. Back to 75mg within a few weeks due to feeling too stimulated and anxious. 

Nov 2023 resume taper. 70, 65, 60, 55, 50 (March 2024)

April 45mg, May 41mg, June 37mg, July 34mg Aug 31mg, Sept 28mg, Oct 26mg, Nov 25mg, HOLD 

Jan 1st 2025 24mg, Jan 12th 23.5mg, Jan 20th 23mg, Feb 20th 22mg, March 20th 21mg, April 14th 18.9mg, May 5th 17mg, May 28th 15.3mg, July 16th 13.7mg, Aug 26th 12.3mg, Sept 16th 10.5 mg, Sept 22, 10mg, Oct 7th 8.3mg, Nov 4th 8mg, Dec 1st 7.7mg, Dec 26th 7mg 2026 Updose to 7.6mg Mar 20th, Back to 7mg Mar 21. Currently holding

 

Other supplements: Fish oil, Mg citrate/glycinate 150-300mg per day, Ginkgo biloba daily, womens multi vit/min 3 times week, Vitamin C 1000mg night, valerian/passiflora as needed. B12 as needed. Bone support for osteopaenia (Ca/Mg, K, D)

  • Author

Hi @Tracey

Thank you for asking. ❤️ I've been struggling a lot. January was the worst month so far... I might post an update soon, but I'll see... I hope you are doing better. ❤️

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

1 hour ago, Marina said:

Hi @Tracey

Thank you for asking. ❤️ I've been struggling a lot. January was the worst month so far... I might post an update soon, but I'll see... I hope you are doing better. ❤️

Hey Marina

 

Im really sorry to read this. Im sorry I meant to message you and see how you were. Yes do post an update.

 

We are all thinking of you and I miss your funny/positive posts.

 

Chippy

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Thank you so much @Chippy ❤️

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

16 hours ago, Marina said:

Hi @Tracey

Thank you for asking. ❤️ I've been struggling a lot. January was the worst month so far... I might post an update soon, but I'll see... I hope you are doing better. ❤️

I am with you in spirit and hope you start to settle very soon. Do what you need to do for your own self. I understand how hard it can be to even read on a computer, let alone do an update. We will all be here when you are ready. 

Be kind and gentle on yourself, this is no easy process. 🩷

Aug 2006 - Sertraline 25/50/75/100mg TO June 2019 - Reduced from 100mg to 50mg over a few months

Sept  2019 - Reduced from 50mg to 25mg lasted a week,  then went back up to 50mg, after a few weeks back up to 100mg.

Oct 2021 - Reduced to 75mg, Dec 2021 (mid) reduced to 50mg , March 2022 - Reduced to 25mg

Oct 2022 - Reduce to 0mg (Immediate withdrawal crying, mood unstable, impending doom, digestive probs, tingling,numbness,burning, brain zaps,  insomnia)

Feb 2023 -  "Panic attack" lasting 14 hours, 2 weeks later start back on 25mg sertraline, 12 hours later severe 'panic attack' with chest pain, tachycardia, restlessness, hyponatraemia, impending doom, racing thoughts, akathisia mild.  Taken to emergency. 

March 2023 back up to 50mg (on medical advice), April 75mg, May 100mg. Back to 75mg within a few weeks due to feeling too stimulated and anxious. 

Nov 2023 resume taper. 70, 65, 60, 55, 50 (March 2024)

April 45mg, May 41mg, June 37mg, July 34mg Aug 31mg, Sept 28mg, Oct 26mg, Nov 25mg, HOLD 

Jan 1st 2025 24mg, Jan 12th 23.5mg, Jan 20th 23mg, Feb 20th 22mg, March 20th 21mg, April 14th 18.9mg, May 5th 17mg, May 28th 15.3mg, July 16th 13.7mg, Aug 26th 12.3mg, Sept 16th 10.5 mg, Sept 22, 10mg, Oct 7th 8.3mg, Nov 4th 8mg, Dec 1st 7.7mg, Dec 26th 7mg 2026 Updose to 7.6mg Mar 20th, Back to 7mg Mar 21. Currently holding

 

Other supplements: Fish oil, Mg citrate/glycinate 150-300mg per day, Ginkgo biloba daily, womens multi vit/min 3 times week, Vitamin C 1000mg night, valerian/passiflora as needed. B12 as needed. Bone support for osteopaenia (Ca/Mg, K, D)

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