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Marina: on/off/on/off Zoloft since end of 2020

Featured Replies

  • Author

@Lighty I am trying, really, I am. Even after my complaining/reply to you, I gave it a try. And it works for a moment, until WD mind just does an override.

I am happy you are able to do this and I hope, in time, I get there too. 🙏🏻❤️ Thank you!

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

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  • Marina
    Marina

    Thank you @SarahMc ❤️ So far the day isn't terrible, hopefully it will continue that way until bedtime. 🙏🏻 I hope you feel some relief as the day goes by. ❤️

  • Marina
    Marina

    Update - 8 and a half months: Many times I wanted to write an update but it was too hard for me to be on here. It was hard on the bad days because I didn't want to sob and complain too much and on t

  • Marina
    Marina

    Thank you @SarahMc and @Fullhealing ❤️ And again, thank you @Chippy and @Luke ❤️ Your comments and encouragement mean more than you know. Yesterday I was so low, but already today after reading what

5 minutes ago, Marina said:

@Lighty I am trying, really, I am. Even after my complaining/reply to you, I gave it a try. And it works for a moment, until WD mind just does an override.

I am happy you are able to do this and I hope, in time, I get there too. 🙏🏻❤️ Thank you!

even with it taking over you can just surrender to it and let the WD do as it wants, instead of adding secondary bad emotions, and ride the bad symptoms, hopefully it makes sense.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

Current Supplements: 6mg melatonin and 133mg magnesium glycinate at night.

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

  • Author

@Lighty I am working on it... 😕

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

27 minutes ago, Marina said:

@Lighty I am trying, really, I am. Even after my complaining/reply to you, I gave it a try. And it works for a moment, until WD mind just does an override.

I am happy you are able to do this and I hope, in time, I get there too. 🙏🏻❤️ Thank you!

It's perfectly fine @Marina don't pressure yourself, there will be moments when no matter what you pull out of the toolbox it won't work.. On days like these, the zen flies out the window, there is no peace, no quiet, only terror and fear and only time is a factor.

We will still continue to try, of course, but without pressure, there is no unnecessary need to add fuel to the 🔥 you are coping the best you can xxx

Edited by Fullhealing

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 20% 0.0358g (2mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of anxiety and sleep that seems to continue to improve.

  • Author

Thank you @Fullhealing 🥺❤️

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

  • Author

This wave is absolutely brutal. It feels like I've passed a new threshold with the level of DP/DR. All symptoms are in their full force. Feels a lot like first months/acute. Sleep is worse and I keep waking up earlier and earlier and then suffering painful tingling in my hands/fingers and also like cold water running through my whole body. (That last thing doesn't feel too bad, really. I feel relief when it happens as it is quite warm/hot.) I usually have a meltdown around lunch and that lasts until the evening. I can't calm myself, I cry the whole afternoon catastrophazing, I feel such restlessness in my body and mind (not sure if akathisia or not) and I also feel like going into panic mode several times during the afternoon. Tinnitus is pretty persistent and annoying as well. It's driving me nuts. My appetite is lower.

I feel like all my symptoms are exacerbated by the sudden rise in temperatures and our AC being disconnected. I generally don't handle heat well. They did, finally, connect our AC yesterday late afternoon and that brings some relief. But I fear how I'll survive the summer. It's going to be incredibly hard in this state.

I have no idea if I'm getting better or worse looking at the whole picture. My windows are getting longer and better, but my waves are also getting worse and more instense. I usually read people saying they are getting longer and better windows but their waves getting shorter and milder. So, I don't know where I stand as both things are equally intensifying. I'm scared. I'm scared my whole summer will be just one absolutely brutal wave. ☹️

I am enduring, even though each day I say I can't do this anymore. I am re-reading KenA's and Ten0275's threads (from the old forum) constantly these days and they give me hope (at least for a short while).

I haven't had much strength to comment on others' threads these last days but I hope all of you are doing better. I wish speedy healing for all of us. 🙏🏻❤️

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

32 minutes ago, Marina said:

This wave is absolutely brutal. It feels like I've passed a new threshold with the level of DP/DR. All symptoms are in their full force.

I'm so sorry you're suffering so much @Marina. It must be particularly upsetting when you were feeling so close to the end of this whole process. I know heat can increase stress a lot, so I'm really glad you got your AC connected. I hope you're still able to spend some time outside, maybe in the evening when it's cooler?

Whether or not you think you're getting better, every day brings you closer to recovery. Keep doing what you need to do to get through the day, and at some point when you least expect it you'll feel that next window. I hope it comes for you soon. Thinking of you and sending healing thoughts your way 💜

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author

Thank you @SarahMc ❤️

I usually do my morning walk and I did it this morning. It wasn't too hot outside so it was okay. Maybe that brought me back to reality a bit. I am also trying to read a bit even though it's hard, but I need distractions and things to keep my mind off WD fatalism. It does feel like I'm desperately holding the door so the monsters won't get in. But I hope in time it won't feel like that.

Thank you, Sarah. Sending back the same wishes for you. 🤗❤️

Edited by Marina

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

4 hours ago, Marina said:

This wave is absolutely brutal. It feels like I've passed a new threshold with the level of DP/DR. All symptoms are in their full force. Feels a lot like first months/acute. Sleep is worse and I keep waking up earlier and earlier and then suffering painful tingling in my hands/fingers and also like cold water running through my whole body. (That last thing doesn't feel too bad, really. I feel relief when it happens as it is quite warm/hot.) I usually have a meltdown around lunch and that lasts until the evening. I can't calm myself, I cry the whole afternoon catastrophazing, I feel such restlessness in my body and mind (not sure if akathisia or not) and I also feel like going into panic mode several times during the afternoon. Tinnitus is pretty persistent and annoying as well. It's driving me nuts. My appetite is lower.

I feel like all my symptoms are exacerbated by the sudden rise in temperatures and our AC being disconnected. I generally don't handle heat well. They did, finally, connect our AC yesterday late afternoon and that brings some relief. But I fear how I'll survive the summer. It's going to be incredibly hard in this state.

I have no idea if I'm getting better or worse looking at the whole picture. My windows are getting longer and better, but my waves are also getting worse and more instense. I usually read people saying they are getting longer and better windows but their waves getting shorter and milder. So, I don't know where I stand as both things are equally intensifying. I'm scared. I'm scared my whole summer will be just one absolutely brutal wave. ☹️

I am enduring, even though each day I say I can't do this anymore. I am re-reading KenA's and Ten0275's threads (from the old forum) constantly these days and they give me hope (at least for a short while).

I haven't had much strength to comment on others' threads these last days but I hope all of you are doing better. I wish speedy healing for all of us. 🙏🏻❤️

So very sorry for the brutal long waves @Marina although very glad for the long bright windows that give you strength to continue, it's very hard to bear especially when you're so close to zero but this pattern is typical and can happen at any stage so don't let doubt creep in, I know it's hard not to but your system is working hard and continues to regulate itself constantly.

You're very strong, remember that, you've survived this far and you will surely continue to do so just hang in there, the positive will outweigh the negative, it's just a matter of time.

Sending much healing, strength and peace your way 🩷

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 20% 0.0358g (2mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of anxiety and sleep that seems to continue to improve.

  • Author

Thank you @Fullhealing 🥺🙏🏻❤️

I am definitely postponing my jump off until I feel some solid ground under my feet.

Thank you again. ❤️ I wish the same for you. 🤗

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

5 hours ago, Marina said:

This wave is absolutely brutal. It feels like I've passed a new threshold with the level of DP/DR. All symptoms are in their full force. Feels a lot like first months/acute. Sleep is worse and I keep waking up earlier and earlier and then suffering painful tingling in my hands/fingers and also like cold water running through my whole body. (That last thing doesn't feel too bad, really. I feel relief when it happens as it is quite warm/hot.) I usually have a meltdown around lunch and that lasts until the evening. I can't calm myself, I cry the whole afternoon catastrophazing, I feel such restlessness in my body and mind (not sure if akathisia or not) and I also feel like going into panic mode several times during the afternoon. Tinnitus is pretty persistent and annoying as well. It's driving me nuts. My appetite is lower.

I feel like all my symptoms are exacerbated by the sudden rise in temperatures and our AC being disconnected. I generally don't handle heat well. They did, finally, connect our AC yesterday late afternoon and that brings some relief. But I fear how I'll survive the summer. It's going to be incredibly hard in this state.

I have no idea if I'm getting better or worse looking at the whole picture. My windows are getting longer and better, but my waves are also getting worse and more instense. I usually read people saying they are getting longer and better windows but their waves getting shorter and milder. So, I don't know where I stand as both things are equally intensifying. I'm scared. I'm scared my whole summer will be just one absolutely brutal wave. ☹️

I am enduring, even though each day I say I can't do this anymore. I am re-reading KenA's and Ten0275's threads (from the old forum) constantly these days and they give me hope (at least for a short while).

I haven't had much strength to comment on others' threads these last days but I hope all of you are doing better. I wish speedy healing for all of us. 🙏🏻❤️

Dear @Marina,

I'm sorry to read you're going through such a difficult time, I wish it were easier for you... At the risk of sounding trite, know that this wave will not last; it will pass. And as time passes, you're getting closer and closer to the other side of this. Even if your mind tries to covince you otherwise, remember that it is WD speaking, not you.

I really appreciate the support you have given me in the past few months so I would love to return the favor. Thank you.

Wishing you lots of strength and more healing ❤️

Took trazodone from June 2023 to November 2023. Didn't notice any withdrawal symptoms when I came off.

 

2023-07-04: started taking paroxetine, 20 mg.

2023-07-30: increased dose to 30 mg.

2023-08-26: lowered dose to 20 mg.

2024-03-21: lowered dose to 10 mg.

2024-07-10: lowered dose to 5 mg.

2024-07-26: 0 mg

 

2024-08-14: reinstated on another AD, this time 10 mg of escitalopram.

2024-11-24: lowered dose to 7.5 mg.

2025-01-15: lowered dose to 5 mg.

2025-03-01: lowered dose to 3.75 mg. (with pill cutter)

2025-03-26: lowered dose to 2.5 mg. (with pill cutter)

2025-04-23: lowered dose to 1.25 mg. (with pill cutter)

2025-05-24: 0 mg

 

Started Rosuvastatin in October 2024 due to high cholesterol. On a break from this med from April 2026 until July 2026.

 

Current supplements: None at the moment

19 hours ago, Marina said:

This wave is absolutely brutal. It feels like I've passed a new threshold with the level of DP/DR. All symptoms are in their full force. Feels a lot like first months/acute. Sleep is worse and I keep waking up earlier and earlier and then suffering painful tingling in my hands/fingers and also like cold water running through my whole body. (That last thing doesn't feel too bad, really. I feel relief when it happens as it is quite warm/hot.) I usually have a meltdown around lunch and that lasts until the evening. I can't calm myself, I cry the whole afternoon catastrophazing, I feel such restlessness in my body and mind (not sure if akathisia or not) and I also feel like going into panic mode several times during the afternoon. Tinnitus is pretty persistent and annoying as well. It's driving me nuts. My appetite is lower.

I feel like all my symptoms are exacerbated by the sudden rise in temperatures and our AC being disconnected. I generally don't handle heat well. They did, finally, connect our AC yesterday late afternoon and that brings some relief. But I fear how I'll survive the summer. It's going to be incredibly hard in this state.

I have no idea if I'm getting better or worse looking at the whole picture. My windows are getting longer and better, but my waves are also getting worse and more instense. I usually read people saying they are getting longer and better windows but their waves getting shorter and milder. So, I don't know where I stand as both things are equally intensifying. I'm scared. I'm scared my whole summer will be just one absolutely brutal wave. ☹️

I am enduring, even though each day I say I can't do this anymore. I am re-reading KenA's and Ten0275's threads (from the old forum) constantly these days and they give me hope (at least for a short while).

I haven't had much strength to comment on others' threads these last days but I hope all of you are doing better. I wish speedy healing for all of us. 🙏🏻❤️

Dear Marina, I am so sorry you having a hard time atm. This healing journey can be so unpredictable, but we do know that healing is happening. I do believe that symptoms can stack, it might be you are having the sudden onslaught of the last few cuts catching up with you. I would hold this dose personally, for an extended period of time (several months) and let your body heal whilst propped up with this little bit of drug.

The heat definitely effects us all. I am noticing it at night in particular. I am glad to see your AC is back on. Great news.

As hard as it is right now, try to just be here in the today and not think about the coming weeks, you are much stronger than you realise and staying present really helps keep the wd brain a little under control in my experience.

Hope today is easier for you xxxx

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

20 hours ago, Marina said:

I have no idea if I'm getting better or worse looking at the whole picture. My windows are getting longer and better, but my waves are also getting worse and more instense. I usually read people saying they are getting longer and better windows but their waves getting shorter and milder. So, I don't know where I stand as both things are equally intensifying. I'm scared. I'm scared my whole summer will be just one absolutely brutal wave. ☹️

I think one thing to consider alongside this, is that you've tapered right down to a very low dose and you're not far from being drug free.

It can often get quite difficult after cuts at the very low doses, but outside of how good/long windows are, and how difficult waves are, you've made immense progress towards being drug free and then healing totally without these drugs.

In that context, you're absolutely making good progress towards getting better.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

  • Author

Thank you guys ❤️

@Niels91 I appreciate the support. ❤️ I really hope this wave subsides soon.

@Chippy I don't know what the cause is... Maybe it's all things - my cycle/hormones, the heat, the cuts... But maybe it's just a wave happening no matter what. Whatever it is, it's happening and I have to endure it. I will be holding the dose. We'll see how that goes. But it's hard not to think about the summer in front of us. I feel immense fear.

Thank you for the encouragement. ❤️

@Luke Thank you. ❤️ I am glad I'm near the end of the taper, but man, it's probably the roughest part (alongside all the other rough parts of this situation).

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

I don't have any personal experience with it, but it does seem like it can be the difficult part for a lot of people.

You're welcome. Please try to hold on to the fact that you've made absolutely huge progress with tapering, even if symptoms are sometimes bad.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

  • Author

@Luke What hurts me the most in my tapering process is how it all went sideways...

I started tapering in October 2024 and everything was going pretty good until my switch to compounded capsules aroung 5mg in September 2025. That was the point of no return and I probably made it worse with my fast and bumpy taper from 5mg to 1mg. From 1mg to 0,1mg I was overly careful, but the damage was already done between 5mg and 1mg. I honestly think that all this is the consequence of what happened between September and (let's say) November 2025.

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

Hey @Marina — just wanted to say thanks for the support you’ve given me, and hope today is a bit calmer for you 💜

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author

Thank you @SarahMc ❤️

So far the day isn't terrible, hopefully it will continue that way until bedtime. 🙏🏻 I hope you feel some relief as the day goes by. ❤️

My story: https://antidepressantrecovery.org/topic/87-marina-onoffonoff-zoloft-since-end-of-2020/

History:

• November 2020 - March 2022: 50 mg Zoloft (first WD - mostly mental symptoms)

• July and August 2022: psilocybin microdosing

• End of August 2022: medium dose psilocybin

• January 2023reinstated Zoloft 50 mg (but probably experinenced adverse reaction/tolerance/poop-out)

• October 2024: started slow taper off Zoloft

• September 2025: switched to compounded capsules (second WD started - both physical and mental symptoms)

• May 2026: still tapering but in liquid form; currently at cca 0,1 mg

 

Symptoms:

Windows and waves pattern of healing.

In a wave:

• severe DP/DR - reality seems strange and creepy and I feel a disconnect from my life, myself, God and the world around me, deep depression, stuck in my head, disinterest for my previous hobbies and work, hopeless, intrusive thoughts, cortisol mornings...

• histamine intolerance, vision problems (eye floaters/VSS/light sensitivity), tinnitus, muscle twitches...

So pleased to hear your day is going relatively well @Marina my it lasts very long 🙏💞

Edited by Fullhealing

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 20% 0.0358g (2mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of anxiety and sleep that seems to continue to improve.

On 6/3/2026 at 9:59 AM, Marina said:

@Luke What hurts me the most in my tapering process is how it all went sideways...

I started tapering in October 2024 and everything was going pretty good until my switch to compounded capsules aroung 5mg in September 2025. That was the point of no return and I probably made it worse with my fast and bumpy taper from 5mg to 1mg. From 1mg to 0,1mg I was overly careful, but the damage was already done between 5mg and 1mg. I honestly think that all this is the consequence of what happened between September and (let's say) November 2025.

It's not your fault.

One way or another, pretty much everyone here was caught out by the harms these drugs could do without proper information from the medical profession, drug companies etc.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

16 hours ago, Marina said:

Thank you @SarahMc ❤️

So far the day isn't terrible, hopefully it will continue that way until bedtime. 🙏🏻 I hope you feel some relief as the day goes by. ❤️

Great to hear Marina! More to come! xxx

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

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