MischaDE: Mirtazapine withdrawal and possible permanent damage

March 6Mar 6

Author

8 hours ago, Richie said:

@MischaDE

stay strong bro you got this man

👊

Thanks man! I appreciate it!

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

1

March 6Mar 6

Author

Thank you to everyone in this thread!

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

1

March 6Mar 6

6 hours ago, MischaDE said:

Yeah looking at it this was does make a difference!

It’s the fight of a lifetime, in a way. For an honest person, of course.

About 1 week of st John's wort

then

20-25 october 2025 : escitalopram 10mg (liquid)

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

Stop everything on 9th december 2025 (last dose 2mg 9th december).

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

"The devil is a liar and he's smiling." 😈

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle. ✨️

March 6Mar 6

Author

34 minutes ago, poulette38 said:

It’s the fight of a lifetime, in a way. For an honest person, of course.

And what if I lose that fight? Because I am really tired…

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

March 6Mar 6

You will not lose it. And we are all here for you. 🙂
Fatigue will not last. Nothing is eternal, if there is at least one justice, it’s that one.

About 1 week of st John's wort

then

20-25 october 2025 : escitalopram 10mg (liquid)

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

Stop everything on 9th december 2025 (last dose 2mg 9th december).

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

"The devil is a liar and he's smiling." 😈

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle. ✨️

1

March 6Mar 6

It is likely that you will recover in time, staying med-free. Unfortunately it can be a lot of time, but equally at 6 months med-free there is a lot of scope for recovery in the future.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.

Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

1

May 6May 6

Hi Misha, How are you doing? I hope the things improved for you. В какой ужась мьi, нечеловеческое съществувание. Лето 2025 думала, что все будет закончивает после месец, два.... Nothing like this, the Living Hell is endless...

Svetla

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

1

May 6May 6

Author

2 hours ago, skamen said:
Hi Misha, How are you doing? I hope the things improved for you. В какой ужась мьi, нечеловеческое съществувание. Лето 2025 думала, что все будет закончивает после месец, два.... Nothing like this, the Living Hell is endless...
Svetla

Hi Svetla, I always read your posts to see how you are, I am sorry you are in such agony, I am still impressed that you are enduring this, I was in your state for about 2 months and I could not anymore, I didnt have and dont have the willpower you do, I think its the eastern block mentality you have...

Me I am struggling a lot with suicidal thoughts and depression, feeling very sick always wanting to throw up, very bad PSSD that is emotionally killing me but thankfully my brain burning has gone away and the headpressure mostly too. 2 months ago it was really bad but now its suddenly gone.

Thank you for asking!

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

1
1

May 6May 6

7 minutes ago, MischaDE said:
Hi Svetla, I always read your posts to see how you are, I am sorry you are in such agony, I am still impressed that you are enduring this, I was in your state for about 2 months and I could not anymore, I didnt have and dont have the willpower you do, I think its the eastern block mentality you have...
Me I am struggling a lot with suicidal thoughts and depression, feeling very sick always wanting to throw up, very bad PSSD that is emotionally killing me but thankfully my brain burning has gone away and the headpressure mostly too. 2 months ago it was really bad but now its suddenly gone.
Thank you for asking!

Always thinking of you Mischa. So pleased the head pressure has mainly gone still. Don’t forget to message me more! Miss you xxx

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

May 6May 6

Author

13 minutes ago, Chippy said:
Always thinking of you Mischa. So pleased the head pressure has mainly gone still. Don’t forget to message me more! Miss you xxx

Alright, thanks Chippy Chip! It's just I have been a bit out of it, I wake up and I am just in absolutely terrible shape. Will message you more! Hope you're slowly getting better!

Edited May 6May 6 by MischaDE

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

1

May 6May 6

Just now, MischaDE said:
Alright, thanks Chippy Chip! It's just I have been a bit out of it, I wake up and I am just in absolutely terrible shape. Will message you more!

Ah Im sorry my guy! I hate to see this. You’re such a trooper! Good things will happen for you. Just a matter of time! And yes you should!

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

May 6May 6

Author

6 minutes ago, Chippy said:
Ah Im sorry my guy! I hate to see this. You’re such a trooper! Good things will happen for you. Just a matter of time! And yes you should!

Thanks Chippy for always emotionally supporting everyone!

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

May 6May 6

Author

2 hours ago, skamen said:
Hi Misha, How are you doing? I hope the things improved for you. В какой ужась мьi, нечеловеческое съществувание. Лето 2025 думала, что все будет закончивает после месец, два.... Nothing like this, the Living Hell is endless...
Svetla

Oh and I forgot to mention that my sleep is better now.

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

1

May 6May 6

Just now, MischaDE said:
Oh and I forgot to mention that my sleep is better now.

This is very good news! Nothing worse than poor sleep!

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

1

May 6May 6

As Chippy said, nothing is worse that the lack of sleep. I am so happy for you, Mischa. Every night since 14 months now (if I can have some sleep) I have waken at 12, 2, 4, 6 h by the awful cortisol/hot/depression waves, with sweats, skin itching and muscle pains. And around 6 o'clock I cannot more stay in bed because of the feeling of terror and dying... I don't know how long I will be able to stay on this inhumane state... My resilience is at its end. But it is great that suddenly your head pressure lifted, Mischa. I read many stories when the people started to feel better one day without progressive signs before. I pray one day to share with you this, I really pray for us.

Svetla

Edited May 6May 6 by skamen

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

2

May 6May 6

Author

19 minutes ago, skamen said:
As Chippy said, nothing is worse that the lack of sleep. I am so happy for you, Mischa. Every night since 14 months now (if I can have some sleep) I have waken at 12, 2, 4, 6 h by the awful cortisol/hot/depression waves, with sweats, skin itching and muscle pains. And around 6 o'clock I cannot more stay in bed because of the feeling of terror and dying... I don't know how long I will be able to stay on this inhumane state... My resilience is at its end. But it is great that suddenly your head pressure lifted, Mischa. I read many stories when the people started to feel better one day without progressive signs before. I pray one day to share with you this, I really pray for us.
Svetla

Yes, I really pray for you too because I know what you are feeling like, it was just like that for me on Mirtazapine...you are very very strong to endure this for such a long time and I genuinely hope you will have some relief soon. I am sorry Svetla, I wish I could do something for you.

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

1

May 6May 6

Hi @MischaDE ,

Thinking of you too ! 😃

You haven’t given us any news for a long time. I was worried.

I am reassured to see that your sleep has finally improved. It's a very important thing I think.

See you soon. Don’t forget that you will win this fight as I told you. Don't ever doubt that.

About 1 week of st John's wort

then

20-25 october 2025 : escitalopram 10mg (liquid)

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

Stop everything on 9th december 2025 (last dose 2mg 9th december).

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

"The devil is a liar and he's smiling." 😈

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle. ✨️

2

May 6May 6

Author

Just now, poulette38 said:
Hi @MischaDE ,
Thinking of you too ! 😃
You haven’t given us any news for a long time. I was worried.
I am reassured to see that your sleep has finally improved. It's a very important thing I think.
See you soon. Don’t forget that you will win this fight as I told you. Don't ever doubt that.

Thanks a lot man! I appreciate it a lot! I hope you are healing as well!

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

May 6May 6

2 minutes ago, MischaDE said:
Thanks a lot man!

Yes but I'm a pretty girl. 🤣🤣🤣 (I'm not @Chippy , you look tired 😂)

About 1 week of st John's wort

then

20-25 october 2025 : escitalopram 10mg (liquid)

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

Stop everything on 9th december 2025 (last dose 2mg 9th december).

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

"The devil is a liar and he's smiling." 😈

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle. ✨️

4

May 6May 6

Author

2 minutes ago, poulette38 said:
Yes but I'm a pretty girl. 🤣🤣🤣 (I'm not @Chippy , you look tired 😂)

Oh ok, I am sorry, pretty woman! :-D

From 27. February 2025 - 15. April 2025 Mirtazapine 15 mg (tried quitting CT 3 times before reinstating after one day, successful CT on attempt 4)

(2 weeks in that timeframe my dose was upped to Mirtazapine 30 mg, I don't remember the exact date when the dose was upped and in which timeframe I took it.)

15. April 2025 - 29. April 2025 Lorazepam 0,5 mg

15. April 2025 - 20. August 2025 on Olanzapine 5 mg

20th of August 2025 - 04. September 2025 tapered off Olanzapine (5 mg to 2,5 mg to 0 mg)

Off all meds since 05. September 2025.

1

May 6May 6

2 minutes ago, MischaDE said:
Oh ok, I am sorry, pretty woman! :-D

😏 I prefer that. I'll forgive you this time. 😌

About 1 week of st John's wort

then

20-25 october 2025 : escitalopram 10mg (liquid)

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

Stop everything on 9th december 2025 (last dose 2mg 9th december).

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

"The devil is a liar and he's smiling." 😈

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle. ✨️

1
1

May 6May 6

remember it's temporary and you can live a good life and be happy even when chronically sick ❤️

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.
Feel free to mention me whenever help is needed.

Current Supplements: Morning: Aloe Vera Gels. Night: 6mg melatonin and 133mg magnesium glycinate. Taking Omega 3 as needed to calm dyskinesia or over stimulation..

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

2

May 6May 6

You got this Mischa Mieees 💪🏻

12 august 2025; 5mg fluoxetine

30 August 2025: 10mg fluoxetine

11 september 2025: 5mg fluoxetine

19 september 2025; 2.5mg fluoxetine

2 oktober 2025: 0mg

I had to cut my pills in half and quarters, so and don’t think I had accurate dosages.

1
1

May 7May 7

9 hours ago, poulette38 said:
Yes but I'm a pretty girl. 🤣🤣🤣 (I'm not @Chippy , you look tired 😂)

@poulette38 you are freeking hilarious sometimes! Love your spirit. 🤣

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys.

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

3

May 7May 7

On 5/6/2026 at 6:08 PM, MischaDE said:
thankfully my brain burning has gone away and the headpressure mostly too. 2 months ago it was really bad but now its suddenly gone.

23 hours ago, MischaDE said:
Oh and I forgot to mention that my sleep is better now.

These are both good signs, even though you're still suffering quite a lot.

For many, that can be how improvements start, symptoms either fade away, become less common or become milder. It doesn't seem to change your position much, but symptoms reducing and fading away is good.

As for sleep, I think that we do a lot of recovery in our sleep, and sleep is essential for health overall. It is good that it is better than before.

I hope in a few more months, you're able to look back and observe that you've improved a little more.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.

Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

2

MischaDE: Mirtazapine withdrawal and possible permanent damage

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