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Featured Replies

As @Chippy and @Sminismoni said, trying to impose a timeline on yourself based on others' experiences can be counterproductive. I went through several months feeling I was making no progress compared to others on PaxilProgress. It was a tough lesson to learn, but I had to accept my healing would come in its own time. For reference, it took me about three years from the start of my final taper to when I could consider myself recovered, but again that was my specific experience and there were a lot of ups and downs during that time. It would be better to work on acceptance and coping and give yourself space and patience to heal at your own pace. Timelines impose unnecessary pressure on yourself.

Started Paxil for GAD in 1999

Unsuccessful taper attempt in 2006

Paxilprogress helped with a successful taper completed in 2009

Using therapy and CBT to manage my anxiety
 

I offer advice based on my experience.  Nothing I share is intended to be medical or therapy advice. 

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  • Chippy
    Chippy

    It is possible to add second fear into the mix for sure, but acceptance and a general good attitude and mindset can help avoid this. WD is very powerful and there are lots out there that will tell you

  • Chippy
    Chippy

    As we I have already said. Please stop looking for stories of people just like you. I can assure you MANY people in this community are poly drugged. It is very common. It is also common for people

  • Chippy
    Chippy

    I know. It can take such a long time for things to settle. But there is always hope. Do remember that most people don’t write a success story on a website. Most just either don’t think too or just wan

@SpiroC I encourage you, if possible, to step back from these thoughts a little bit and notice that you are still reassurance seeking. This is a classic anxiety loop. Years ago I ran a CBT group, and the number one lesson was that checking and seeking reassurance maintains the anxiety in the long run. Try to distract if you can't challenge these thoughts, and avoid triggers. A temporary step away from forums and YouTube might also help manage these thoughts. I get it, sometimes they grip you despite your best efforts. It's fine to post that you are struggling, that you are tormented by thoughts, that you feeld despair. We all get that. But we can't enable the reassurance seeking cycle by giving you answers here.

Personally I think it's mildly irresponsible of these coaches to give timelines. It smacks of toxic positivity in my book, which seems an American cultural phenomenon. I saw a coachlast week who thankfully gave me no such thing. I think that is the right approach.

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

  • Author
5 hours ago, Sminismoni said:

@SpiroC I encourage you, if possible, to step back from these thoughts a little bit and notice that you are still reassurance seeking. This is a classic anxiety loop. Years ago I ran a CBT group, and the number one lesson was that checking and seeking reassurance maintains the anxiety in the long run. Try to distract if you can't challenge these thoughts, and avoid triggers. A temporary step away from forums and YouTube might also help manage these thoughts. I get it, sometimes they grip you despite your best efforts. It's fine to post that you are struggling, that you are tormented by thoughts, that you feeld despair. We all get that. But we can't enable the reassurance seeking cycle by giving you answers here.

Personally I think it's mildly irresponsible of these coaches to give timelines. It smacks of toxic positivity in my book, which seems an American cultural phenomenon. I saw a coachlast week who thankfully gave me no such thing. I think that is the right approach.

Noted @Sminismoni - I think that this is just such a scary experience especially when I personally didn’t catch what was happening sooner and ended up with severe pollydrugging that it kinda scares me that I’ll be the guy that dosent heal. Just 8 months ago my life wasn’t half bad and I was quite content. So it’s hard to imagine how bad it’s got so quick and I think that’s why I’m seeking reassurance.

Your insights are appreciated and I’ll try and be more cognizant of that.

I think from the coaches perspectives they have seen hundreds if not thousands of ppl and they can generally gauge a timeline from anecdotal experience based on averages. Thats why I raised it.

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

You don’t have to explain yourself @SpiroC . We are all desperate for answers.

1998 -1999 Paxil CT after 5 months.

1999 - 2024 every 2 to 4 years went from one SSRI to the next. That includes Luvox, Zoloft, Cymbalta, Celexa, Prozac, Lexapro.

2000-2024 lorazepam 2mg.

April 2024 one dose of Effexor, July 2024 one dose of Paxil, July 2024 two weeks of Mirtazapine. September 2024 Lexapro 10mg, Depakote 250mg, Vistaril 25 mg ,Proppranolol 10mg, Requip 2mg Trazadone 50mg. March 2025 off Depakote,Propranolol,vistaril,Trazadon.

March 2025 Zyprexa added at 2.5 mg.”for sleep and anxiety”. Went up to 7.5mg in June.

September 2025 started tapering Zyprexa and Requip.

February 2026 off of Zyprexa and Requip. Reduced Lexapro to 5mg

7/4/2026-4.5mg

8/1/2026-4.0mg

10 hours ago, SpiroC said:

I think from the coaches perspectives they have seen hundreds if not thousands of ppl and they can generally gauge a timeline from anecdotal experience based on averages. Thats why I raised it.

It is very normal to want a sense of a timeline, give you some hope. We have all been there. Luke and I have talked timelines quite a bit. I am personally more in the 'don't worry about it' camp as I said, but certainly coaches do have a good idea of how long people have taken to recover, but obviously you could be less or more time, and that recovery period varies hugely from person to person. So really it doesn't help you knowing this.

It is so normal to seek this out, but eventually I believe we must all settle on acceptance and stop looking for answers. It's ok it takes you a little time to come to this conclusion, I think it does to varying degrees for us all.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

@Chippy - Question for you..

In SA - Alto always speaks about , drug interactions and side affects of drugs.

Being on two sedative drugs like Clonazepam and Seroquel I feel so tired every day like I have lead in my boots. She often advises people to lower the doses to reduce / reverse these affects.

It’s a conundrum because on the one hand the meds are causing these adverse side affects and on the other hand we just have to hold on them to stabilize. It truly is a rock and a hard place situation.

Would like to know your thoughts on this ?

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

  • Author

I was reading a paper by Dr Reg Peart and he was speaking about drug toxicity and how drugs can become more toxic the longer you’re on them I.e benzodiazepines.

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

31 minutes ago, SpiroC said:

Would like to know your thoughts on this ?

in that situation where the drugs themselves significantly impact your life negatively, you just have to balance out wd/drug reactions, if you are very unstable I would tell you to hold.

but let's say you are decently stable, you may see that by tapering 5% or 10% hyperbolically per month, you see you are less tired but your wd is a bit ramped up, you may decide that less tiredness is worth the wd being 1-2 worse on a 1-10 scale.

but tapering faster than that might lead to wd being too strong so that it's not worth being less tired.

Essentially it's all a game of managing the drug effects and WD. and you will have to listen to your body to know how much can you take, and when.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 
Feel free to mention me whenever help is needed.

 

Current Supplements: Morning: Aloe Vera Gels. Night: 6mg melatonin and 133mg magnesium glycinate. Taking Omega 3 as needed to calm dyskinesia or over stimulation..

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

  • Author
5 minutes ago, Lighty said:

but tapering faster than that might lead to wd being too strong so that it's not worth being less tired

Hi Lighty , yes most definitely hear you there. It can be violent beyond words !

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

58 minutes ago, SpiroC said:

In SA - Alto always speaks about , drug interactions and side affects of drugs.

Being on two sedative drugs like Clonazepam and Seroquel I feel so tired every day like I have lead in my boots. She often advises people to lower the doses to reduce / reverse these affects.

@SpiroC I would also add that fatigue or exhaustion can also be a symptom of a destabilized nervous system. I'm struggling a lot with fatigue, especially mental fatigue, and I'm only on 12.5 mg of seroquel so I doubt very much it's a drug side effect. On better days my brain clears a little bit and I have a bit more energy. You're taking more sedative drugs than me so it's certainly possible you're experiencing fatigue as a side effect, but you're also very destabilized so it might be hard to know for sure what's causing you to be so tired.

I'd be really cautious about starting a taper while you're still quite unstable. Just my two cents 💜.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author
22 minutes ago, SarahMc said:

I'd be really cautious about starting a taper while you're still quite unstable. Just my two cents 💜.

Completely agree with you here Sarah and thank you for your thoughts. I’m not suggesting taper I’m just thinking why I’m always so lethargic - it’s part drug / part withdrawal

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

14 hours ago, SpiroC said:

@Chippy - Question for you..

In SA - Alto always speaks about , drug interactions and side affects of drugs.

Being on two sedative drugs like Clonazepam and Seroquel I feel so tired every day like I have lead in my boots. She often advises people to lower the doses to reduce / reverse these affects.

It’s a conundrum because on the one hand the meds are causing these adverse side affects and on the other hand we just have to hold on them to stabilize. It truly is a rock and a hard place situation.

Would like to know your thoughts on this ?

I think you have answered your question a bit, reducing one of the more sedative drugs is a good move if you feel a bit sedated, but you might want to wait to do that until things have settled down before you try would be my thought. Use it more as a guide as what to taper first.

I also agree with @SarahMc it could be perhaps this is a WD effect rather than a drug interaction/side effect.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

On 7/12/2026 at 4:55 PM, Sminismoni said:

Personally I think it's mildly irresponsible of these coaches to give timelines. It smacks of toxic positivity in my book, which seems an American cultural phenomenon. I saw a coachlast week who thankfully gave me no such thing. I think that is the right approach.

It's difficult, as when people book appointments with them that's often the main thing they want to know, and it's a question that comes up time and time again in all of the prescribed harm communities I've been in. In many ways, it's natural to ask "when will I be better?". People are typically not good at dealing with the unknown, whereas a fixed amount of suffering, even if it's long, is easier to begin to come to terms with.

That said, you're right, in that it's not necessarily helpful either.

15 hours ago, SpiroC said:

It’s a conundrum because on the one hand the meds are causing these adverse side affects and on the other hand we just have to hold on them to stabilize. It truly is a rock and a hard place situation.

Unfortunately it's very difficult to know what to do and there isn't always a "right answer". People can give you their thoughts, and they might be based on what they've experienced or seen others do, but that's all we really have. You're right, it is a conundrum and I sympathise a lot with feeling stuck between a rock and a hard place.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

  • 3 weeks later...

Hey @SpiroC how are you doing these days?

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author
1 minute ago, SarahMc said:

Hey @SpiroC how are you doing these days?

Hi Sarah, thanks for checking in. I’m surviving- still housebound and scared for how long things going to take. I still have a feeling that these meds are making me feel terrible but all I can do is hold my doses.

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

  • Author

How’s everything your side @SarahMc ?

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

17 minutes ago, SpiroC said:

Hi Sarah, thanks for checking in. I’m surviving- still housebound and scared for how long things going to take. I still have a feeling that these meds are making me feel terrible but all I can do is hold my doses.

I'm sorry Spiro. I also hate being on the meds and am worried about adverse effects. Have you had any windows at all?

18 minutes ago, SpiroC said:

How’s everything your side @SarahMc ?

I've been in a really bad wave the last week and a half or so. Feeling really beat down and disheartened. Before this I felt like I was making progress, even if it was really slow. But we'll get there together 💜.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author
6 hours ago, SarahMc said:

I'm sorry Spiro. I also hate being on the meds and am worried about adverse effects. Have you had any windows at all?

Night times are a bit better Sarah…

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

  • Author
6 hours ago, SarahMc said:

I've been in a really bad wave the last week and a half or so. Feeling really beat down and disheartened. Before this I felt like I was making progress, even if it was really slow. But we'll get there together 💜.

Really sorry to hear that … I pray for you soon it lets up.

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

19 minutes ago, SpiroC said:

Really sorry to hear that … I pray for you soon it lets up.

Thanks Spiro. Glad to hear you at least get a bit of relief in the evenings. One day at a time, I believe we will both heal.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author
2 minutes ago, SarahMc said:

Thanks Spiro. Glad to hear you at least get a bit of relief in the evenings. One day at a time, I believe we will both heal.

From your lips to Gods ears my friend 🙏

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

@SpiroC Good to hear you get some relief in the evenings. Hang in there, healing is happening.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • 4 weeks later...
  • Author

Hi All,

Very confused by this.

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

  • Author

So what he’s saying is that holding isn’t always your best bet? Like I’ve been severely injured

Spiro

Current Medications (April 2026)

* Zoloft 125mg (a.m.)

* Seroquel 75mg (night)

* Clonazepam 0.5mg (a.m.)

Drug History

January 2013 Zoloft 100mg

~2021 Xanax 0.5mg PRN (once every 2 weeks)

July 2025 Zoloft 0mg

October 2025 Lithium 150mg

October 2025 Gabapentin 600mg

October 2025 Seroquel 200mg

December 2025 Seroquel 25mg

January 2026 Lithium 0mg

January 2026 Zoloft 100mg

January 2026 Zyprexa single dose

January 2026 Geodon injection

January 2026 Lamotrigine 100mg

January 2026 Seroquel 200mg

March 2026 Lamotrigine 0mg

March 2026 Seroquel 75mg

March 2026 Gabapentin 0mg

March 2026 Clonazepam 0.5mg twice daily

April 2026 Clonazepam 0.5mg

April 2026 Zoloft 125mg

April 2026 Seroquel 75mg

Taper / Change Details

* July 2025: Tapered Zoloft from 100mg → 0mg over ~4 weeks:

* Week 1: 50mg

* Week 2: 25mg

* Week 3: 12.5mg

* Week 4: 0mg

* December 2025: Tapered Seroquel from 200mg → 25mg over a few weeks (rapid taper)

* January 2026: Lithium stopped (150mg → 0mg)

* March 2026: Lamotrigine stopped (100mg → 0mg)

* March–April 2026:

* Tapered Seroquel from 200mg → 75mg over ~5 weeks

* Tapered Gabapentin from 600mg → 0mg over ~5 weeks

* Clonazepam: Started at 0.5mg twice daily → now 0.5mg morning only

16 hours ago, SpiroC said:

So what he’s saying is that holding isn’t always your best bet? Like I’ve been severely injured

Good question @SpiroC, I can see why you'd be confused. It seems to me like Dr. Josef in this video is talking about a pretty simple scenario where you come off one drug, then reinstate that same drug pretty shortly afterwards but don't get noticeably better within a couple months. I'm not sure to what extent that would apply to a more complicated situation like you or me since we've been cycled through a bunch of different drugs and our nervous systems are very unstable.

Have you ever talked to Dr. Horowitz? It might be worth setting up an appointment with him if you're worried that holding isn't helping you.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

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