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Featured Replies

  • Author
1 hour ago, Luke said:

report no real withdrawal symptoms, and no changes nor fluctuations.

@Luke I do have fluctuations in physical symptoms and get horrific neuroemotions, but the symptoms I described above are there constantly in the background, without any fluctuations. The last time I felt enjoyment or interest was 6 months ago. I don't feel connected with my surroundings. There's no spark. I optimistically bought tickets to a flower show, which is normally right up my alley, but I really don't care if I go or not, even if I am physically well enough on the day. I regret wasting the money. I am also very cognitively slowed and can no longer quickly take in information or learn new things. I used to be an information sponge, soaking up data. It's all just dead inside my head. Hence my concern that there is an aspect to this which may be permanent.

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

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Top Posters In This Topic

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  • Chippy
    Chippy

    @Sminismoni You will recover, you have to unapologetically believe in this. Any other thought is not an option. That data set is so tiny, its virtually pointless to look at. I really believe that spe

  • Sminismoni
    Sminismoni

    Thank you Luke. If I feel any better later this year I plan to do a Grand Rounds presentation in my Trust to educate my colleagues on this. I plan to be very transparent and present myself as a case r

  • Sminismoni
    Sminismoni

    I have sent an email this morning to the National Deprescribing Clinic as follows (will update if I get a reply):   Dear Team,   I am an Australian-trained Fellow of the Royal Aust

  • Author
11 minutes ago, Sophia said:

don’t understand how it’s even humanly possible to be unable to feel sick, tired, drunk, hungover, regular headaches… it’s so unnatural

I don't feel tired, stressed, or normally worried about things either. Alcohol also did nothing - I drank it until 3 months into withdrawal and I remember thinking that I couldn't feel it relax me.

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

1 hour ago, Sminismoni said:

the symptoms I described above are there constantly in the background, without any fluctuations

I have the same…. My 4 main symptoms (head pressure/weird head sensations, emotional blunting, anhedonia and severe dry eyes without any tear reflex) are there always

Edited by Sophia

12 august 2025; 5mg fluoxetine 

30 August 2025: 10mg fluoxetine 

11 september 2025: 5mg fluoxetine 

19 september 2025; 2.5mg fluoxetine 

2 oktober 2025: 0mg

 

I had to cut my pills in half and quarters, so and don’t think I had accurate dosages.

Hi I try not to come on the site too regularly as I go down rabbit holes but I saw your posts on my page.

One day when I’m better I’m going to somehow get my story across to the mental health trust here where I live, I worked for them for 20 years and it’s one of their doctors who put me on my fluoextine following my adverse reaction to Compazine.

It made me 1000 times worse until I finally settled but I was never ‘right’ on it hence the taper and coming off.

I’m at 16 months now so a way ahead of you.

As you can see from my page I’ve had many ups and downs.

I started to get longer windows in month 10 which lasted 2-3 weeks. I had a 6 week window around March time.

Things move around but for me agitation/fear is the main consistent symptom I’ve had all this time and it’s debilitating on wave days. On window days it can now 100% go which it didn’t in the past.

I still get pockets of depression which sadly seem to be worse the past 2 months, but my looping brain (kinda opposite to yours) has eased off significantly in those 2 months.

I am in a nasty wave today so feel hopeless hence coming on the site, but they always lift.

I’ve had waves now for 12 months since mt acute ended and they always always lift to a window, and I have to remind myself of that!

I’ve also scoured these pages and have found a million success stories which I read in a wave.

This is a horrid journey and it’s a scary one. I feel scared that I’ll be like this forever, even though my rational brain knows that I’ve made improvements in the last 16 months.

I really hope you some good windows soon and/or some lifting of Symtoms.

You are amazing to keep working. If I didn’t have these depression pockets with weeping I’d like to try and work, but sadly I can’t work as on those days pretty much all I do is cry!!

Sending love and hope

Rosie x

- Compazine injury following surgery used as an anti nausea drug Feb 2023, led to agitation and racing thoughts 

- tried to cope med free, advised to start Prozac May 2023 20mg 

- made me worse but was told to persevere, believe I had an adverse reaction. 
- decided to taper after 6 months of use at 20mg. Went down over 14/15 months to 1.5mg.

- February 2025 came off 1.5mg due to feeling good and didn’t know this would lead to such strong WD

  • Author

I am just in complete despair. I went on SA and cannot really find recovery stories from emotional blunting and anhedonia. The thread under that topic was very negative. I have 24/7 derealisation and numbness when negative neuro-emotions aren't at play (and even those feel "blunted" compared to the first 3 months of WD). Amotivation, like I have bricks inside me and can't start tasks. Nothing interests me. I used to love flowers, books. Now I couldn't care less. And I can't concentrate to read or absorb new information.

I can't find any recovery stories where this was the constant symptom either. I am beginning to realise that the physical WD might resolve but the PSSD aspect may not. I don't know how I can live like that. I used to have such a rich inner world. I can't access that at all anymore. I feel so hopeless today.

The way I've coped with all of this so far is to think that in 2 or 3 years I will be my old self again. Or even 5 years. But the thought of not having my sharp mind, my imagination, my creativity, my feelings for music, art, nature back ever, is destroying me.

Edited by Sminismoni

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

@Sminismoni Hi, have you tried going on the internet and typing in "anhedonia and emotional blunting success stories". You'll find many links from others on Reddit, Benzobuddies and others who have gone through the same and posted success stories. Good luck.🙂

2008, 10 mg citalopram, 2.5 mg bendroflumethiazide. 

2021 reduced citalopram over 3 years and stayed on 5.2 mg citalopram for approx. 1 year. 

Sept 2023 taken off all meds and put on amitriptyline 10 mg and Ramipril 2.5 mg. 

October 2023 taken off amitriptyline and ramipril and put on propranolol 10 mg and Losartan 25 mg. 

November 2023 taken off propranolol and losartan. 

December 2023 back on citalopram 0.5 mg and bendroflumethiazide 2.5 mg. 

February 2024 taken off bendroflumethiaide put on bisoprolol 1.25 mg but came off it same month. Put on ramipril 1.25 mg, still on citalopram 0.5 mg. Stopped ramipril same month. Decided to quit all meds.

June 2024 0.45 mg citalopram

July 2024 0.4 mg citalopram

October 2024 0.2 mg citalopram but had to increase to 0.3 mg same month

January 2025 quit citalopram at 0.3 mg CT.

Not taking any prescription meds currently, health checks have been good results to date.

Anhedonia for two years, healed! https://benzobuddies.org/topic/266718-anhedonia-for-two-years-healed/

Dear @Sminismoni, please read the above link.

Long term use of ADs caused my awful anhedonia which became unbearable with the CT. Since February 2024 I have not been me, not interest for nothing, an internal blockage for everything I used to love to do, I cannot recognize me. In addition of this I am in the Hell of horrid inner akatisia, cortisol torture, insomnia, feeling of dying... I feel you very well.

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

12 august 2025; 5mg fluoxetine 

30 August 2025: 10mg fluoxetine 

11 september 2025: 5mg fluoxetine 

19 september 2025; 2.5mg fluoxetine 

2 oktober 2025: 0mg

 

I had to cut my pills in half and quarters, so and don’t think I had accurate dosages.

Thank you, @Sophia, for these links. Pleas post other ones when you find them.

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

  • Author

I am so hopeless and the only thing that was helping me cope up until this point was believing in recovery. That one day I would have my sense of self, my physical health, my brain and normal emotions back. But I'm reading the Hengartner paper again on Protracted withdrawal using data from SA.

It's not filling me with hope. ChatGPT:

If you're trying to answer the specific question, "Of the people in this paper whose outcome was actually known, how many recovered?", then:

Recovered (natural + reinstatement + other treatment) = 15 people

Partially recovered = 12 people

Suicide = 2 people

Outcome unknown/not reported = 36 people

So among the 33 people with a known outcome, about 45% were reported as recovered, 36% partially recovered, and 6% died by suicide.

This is not a life.

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

@Sminismoni You will recover, you have to unapologetically believe in this. Any other thought is not an option.

That data set is so tiny, its virtually pointless to look at. I really believe that spending time looking for proof of healing is pointless and just leads down a rabbit hole of despair.

If you must read that data, I see something more positive in the numbers. Nearly 50% of those people 100% recovered and most of the others are currently on their way to recovering 100% but are not there yet. Sadly a small number didn't find the strenth to keep going, don't let that be you. xxx

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

3 hours ago, Chippy said:

@Sminismoni You will recover, you have to unapologetically believe in this. Any other thought is not an option.

That data set is so tiny, its virtually pointless to look at. I really believe that spending time looking for proof of healing is pointless and just leads down a rabbit hole of despair.

If you must read that data, I see something more positive in the numbers. Nearly 50% of those people 100% recovered and most of the others are currently on their way to recovering 100% but are not there yet. Sadly a small number didn't find the strenth to keep going, don't let that be you. xxx

Wish I could ‘like’ this 1000x!!

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

On 6/21/2026 at 10:24 AM, Sophia said:

Did you feel that as well Luke? Like the way your brain felt and worked was completely altered?

Very much so, for a long time, although I was constantly extremely exhausted and physically sick as well.

On 6/21/2026 at 10:34 AM, Sminismoni said:

@Luke I do have fluctuations in physical symptoms and get horrific neuroemotions, but the symptoms I described above are there constantly in the background, without any fluctuations. The last time I felt enjoyment or interest was 6 months ago. I don't feel connected with my surroundings. There's no spark. I optimistically bought tickets to a flower show, which is normally right up my alley, but I really don't care if I go or not, even if I am physically well enough on the day. I regret wasting the money. I am also very cognitively slowed and can no longer quickly take in information or learn new things. I used to be an information sponge, soaking up data. It's all just dead inside my head. Hence my concern that there is an aspect to this which may be permanent.

I get that, and I had that concern for a very long time. I still think you're experiencing withdrawal syndrome, and that it will improve in time.

None of what you're describing is "abnormal" for withdrawal and there have been plenty of others who experienced similar, who eventually went on to improve and then recover.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

  • Author

Another very bad day. I wonder if it's the heat. I am bedbound, fatigued, can't move, I just feel heavy. Walking to the toilet requires too much effort. I haven't eaten. Very blurry vision with a completely dense head with no concentration amd few thoughts. No emotions, complete apathy that is absolutely tormenting. I want to die. I can't face the prospect of never enjoying a sunset again or being sparked by a topic and buying 6 books on it and reading them all in a matter of weeks. That's the person I was. I don't want life if I can never get that back.

I am still tormented by the negativity on other subs like Reddit. People who are like this for years with no feelings and apathy, with ongoing major symptoms and saying they got worse at 3 years off etc.

I'm not sure why I don't read those kinds of super negative Reddit stories here,. These kind of people weren't on SA either as far as I could see. Who are those people? Are they just so protracted they've given up on support groups? Do they like posting as a form of misery porn? It truly confuses me. Keen to hear your thoughts @Luke and @Chippy. I just find them so triggering and don't understand how their conversation on medication harm can be so much more pessimistic, and the cases so much more extreme. On the flip side, I have avoided a lot of the American withdrawal coaches and support groups too, because I find them almost the opposite. There is a vibe of toxic positivity about some that really puts me off, and a one size fits all approach, with lots of focus on activation style symptoms such as akathisia but little focussing on those who have apathy and blunting (which gets me hopeless too).

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

Hey @Sminismoni I’m sorry for your suffering. Luke and Chippy may have more insight than me — but one thing I would say about Reddit is that you don’t generally get the kinds of detailed stories, med histories, and back-and-forth conversation that you get here, and previously on SA. So it’s really difficult to know, for example, why someone may have worsened at 3 years off, or what may have caused a particular case to be so extreme and protracted.

Even the worst cases I have read about here, on SA, and in more long form sources like Mad in America, have seen progress over time, and even if not fully recovered several years out continue to see positive progress.

As hard as it may be, we need to try hard to believe in our own recoveries.

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

  • Author

@SarahMc I can't seem to fight the hopelessness. No amount of challenging or self compassion or any srrategy is helping to shift this. It is so strong, and I am so pessimistic.

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

26 minutes ago, Sminismoni said:

@SarahMc I can't seem to fight the hopelessness. No amount of challenging or self compassion or any srrategy is helping to shift this. It is so strong, and I am so pessimistic.

I think that overwhelming sense of despair hits us all at times, but I’m sorry it’s so stubborn for you 😢 It will lift! I’ve been in it for weeks at a time before, and just had to keep repeating to myself that it was temporary to get myself through, even though my brain refused to believe it.

One thing I would really strongly recommend is to avoid triggers like Reddit, or anything else that drags you further down into the pit. Try to focus on positive stories and other distractions that at least used to make you feel good, even if they don’t have the same effect right now. One day they will again 💜

I’m not a medical professional and cannot offer medical advice. I am new to this journey and my thoughts are based only on my personal experience with psychiatric drugs. This is a peer site where we support each other on our taper/recovery journeys. 

Current regimen:

Cymbalta - 90 mg/day

Seroquel - 12.5 mg/day

*holding to stabilize as of Apr 2026

 

History:

Seroquel - up to 50 mg as needed for sleep (generally 6.25-12.5 mg a few times a week, though sometimes more) - 2009 (ish) to present

Cymbalta - 60 mg/day, periodically down to 30 mg/day - May 2014 to May 2025

Clonazepam - up to 1 mg/day as needed - March to May 2025, quick taper off

Zoloft - 150 mg/day - May 2025 to Aug 2025 (quick cross-taper from Cymbalta)

Pristiq - 50 mg/day from Aug 2025 to mid-Oct 2025 (quick cross-taper from Zoloft); 100 mg/day from Oct 2025 to Dec 2025; back down to 50 mg/day from Dec 2025 to Jan 2026

Lyrica - 200 mg/day - Nov 2025 to Jan 2026 (quick taper off from mid-Jan to early Feb 2026 due to severe depressive symptoms)

Cymbalta - 60 mg/day - Jan - March 2026; up to 90 mg/day from March to present

 

5 hours ago, Sminismoni said:

Another very bad day. I wonder if it's the heat. I am bedbound, fatigued, can't move, I just feel heavy. Walking to the toilet requires too much effort. I haven't eaten. Very blurry vision with a completely dense head with no concentration amd few thoughts. No emotions, complete apathy that is absolutely tormenting. I want to die. I can't face the prospect of never enjoying a sunset again or being sparked by a topic and buying 6 books on it and reading them all in a matter of weeks. That's the person I was. I don't want life if I can never get that back.

I am still tormented by the negativity on other subs like Reddit. People who are like this for years with no feelings and apathy, with ongoing major symptoms and saying they got worse at 3 years off etc.

I'm not sure why I don't read those kinds of super negative Reddit stories here,. These kind of people weren't on SA either as far as I could see. Who are those people? Are they just so protracted they've given up on support groups? Do they like posting as a form of misery porn? It truly confuses me. Keen to hear your thoughts @Luke and @Chippy. I just find them so triggering and don't understand how their conversation on medication harm can be so much more pessimistic, and the cases so much more extreme. On the flip side, I have avoided a lot of the American withdrawal coaches and support groups too, because I find them almost the opposite. There is a vibe of toxic positivity about some that really puts me off, and a one size fits all approach, with lots of focus on activation style symptoms such as akathisia but little focussing on those who have apathy and blunting (which gets me hopeless too).

@Sminismoni

Honestly: NO REDDIT. One day I read a post from a guy who talked about his experience with ADs: "it was great," he said, that jerk. And I’ve read others, which don’t immediately come to mind. I suspect a lot of these "bots" to be ill-intentioned people, who maybe have never even taken any medication! Who can confirm this ? We don't know these people in real life! Caution is required. Critical thinking is definitely not an option (in general, but especially on this kind of site).

About 1 week of st John's wort

 

 

then

 

20-25 october 2025 : escitalopram 10mg (liquid)

 

 

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

 

Stop everything on 9th december 2025 (last dose 2mg 9th december).

 

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

 

"The devil is a liar and he's smiling." 😈

 

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle.

 

@Sminismoni i think Reddit is a garbage site when it comes to getting valid & useful

Information. I perused it once and decided not to waste my time. I wouldn’t trust anyone there when comes the stuff we all deal with here.

Pokeys Topic

Pokeys Archived Dose hHistory

Current Medication:

2.5mg of nebivolol for BP

5mg Eliquis x2.

Vitamin D, 40mg Famotidine PRN

Magnesium glycinate ,5mg melatonin

20 March 2025 - Mirtazapine - 7.5mg (+41.5%)

20 Feb 2026 - Doxepin 29.6mg (0.6mg updose)

On 1/30/2026 at 4:53 AM, Sminismoni said:

The absolute worst part about my withdrawal journey for me is the emotional blunting, lack of interest, inability to feel joy, get excited or want to do anything. Most days I can't even cry, I'm an emotional robot. Music, nature, art, all things that used to make my life rich mean nothing now. I could see someone murdered in front of me and probably shrug my shoulders and walk away. I also often feel physically sluggish and weighed down. Add in vague derealisation a lot of the time, and I cannot voluntarily initiate tasks, or connect to them in any meaningful way, let alone people. There is no urgency to anything, no sense of time or a future. This, more than any physical symptom has ruined my life. Today I have relatively few physical symptoms but this emotional bit never goes away, there is no reprieve. I can't even "feel" supported by others, if that makes sense. This is the most difficult symptom to describe to others as well.

I relate to this sooooo much and I am also in the field. Though as a therapist but I’ve worked with psychiatrist for years to prescribe. I also have severe anhedonia and blurry vision, heavy days where I can barely walk to the bathroom also burning joints fragile body feels like I can barely

Walk I miss feeling embodied (sexy even) having fun feeling strong and goofy. Having sex doing yoga blissing out to food and music I can’t believe this is my reality.

I pray we heal

2003-2023 on SSRIs (different ones over the years) did a slow taper 

Aug 2023-completely off. No real symptoms, besides increased anxiety and some emotional volatility, but also was in an abusive relationship

June 2024-did psilocybin therapy to help me leave relationship. Afterwards could not eat and was in panic every day.

April 2025-try to reinstate SSRI (6days Prozac 10mg then 5 days Zoloft at varying mg)=11 days severe adverse reaction total akathesia, DP/DR, brain burning 

April 8, 2025 last 2.5 mg Zoloft nothing since

Current/Symptoms post adverse reaction: severe anhedonia, burning in hips and hand, VSS, floaters, feel empty, don’t feel embodied, flat fuzzy. B4 this even during bad times I felt energetic and joyful for the most part. Felt a lot and now I feel nothing.

 

@SarahMc makes a good point. On forums like this and SA, people are obliged to post their medication histories, and they post about their story all in one place.

The PSSD forum, for example, is absolutely plagued by people doomposting and saying they've "had PSSD for X years" who have either spent those years going on and off of medications, or are even still taking them.

Likewise, I've been in various fb and whatsapp groups and over time I've come to learn that many of the most vocal posters are hiding parts of their drug history. These groups often had quieter members who posted intermittently who were slowly getting better over time.

We're pretty firm about posting drug histories in signatures, and being honest and open about it here. We put significant amounts of our time, effort and money into this site and helping people, and it still happens that we learn about new reinstatements or drugs having been thrown into the mix, having put lots of time and effort into trying to help someone understand why they've taken a downturn over weeks or months.

Are there people who suffer for a long time? Absolutely. Can these drugs cause severe harms? Again, yes. I would count myself among those. Still, It is slowly getting better.

At less than a year off of these drugs, there is so, so much precedent for improving and then recovering in time.

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

18 hours ago, Sminismoni said:

@SarahMc I can't seem to fight the hopelessness. No amount of challenging or self compassion or any srrategy is helping to shift this. It is so strong, and I am so pessimistic.

Im sorry @Sminismoni I think for some coping skills offer little support, the symptoms are too strong, this won't be this way forever, as you heal and thing become less acute you will be able to engage with coping skills more readily I'm sure of it. For the minute just surviving is enough x

19 hours ago, Sminismoni said:

Keen to hear your thoughts @Luke and @Chippy.

I have nothing to add that has not been said by others really. I don't spend time on reddit and consider it all a bit random and frankly the gutter of the internet! I don't and have not read success stories either. I don't relate with most people in WD tbh, I just accept my current position and look to the future, trusting my body to put it all right for me. Some days it is easier to believe than others.

The big point here to highlight is that people are generally terrible for hiding what they have been taking from us all, as Luke pointed out, on here we see those who worsen often have been drinking or taking other drugs, and that's fine, they owe us nothing realy we are just strangers on the internet after all, but it does colour the results when we look at thier cases for sure.

Ultimately you are a smart well educated individual who knows to not add to the mix with other drugs and substances, who is doing everything she can to provide a solid platform for healing, trust this is enough.

I found a really useful post on a video once that I think sums this up, if you have not read it already.

“There is a lot of different language in our community about being broken, being injured, being permanently damaged but there are multiple ways to look at this. I knew my withdrawal from psychotropic drugs as the most intense and severe disruption my nervous system has ever experienced.

So I suffered. And I suffered hard. And there were many days I had zero hope. I was miserable and just sort of put an invisible football helmet on my head, put my head down, and grinded out the time. I was in an invisible prison and didn’t know when the judge would let me out.

There is a magic place where surrender, radical acceptance, patience, distraction, and delusion meet. I was delusionally optimistic as if I had a psychic laser that would take me to healing. I did not want to entertain any other outcome. And would you look at that. All my “delusion” paid off and here I am on the other side, throwing a rope to you to show you how to do this.

And you won’t be perfect. All of this is messy. You will trip and fall and scrape your knees and beg God himself to rescue you from this hell and he won’t, and then you’ll curse his name. You will have hope one day and then not again for a month. And all of this is okay. Because you will heal despite kicking and screaming for it to be different.

So please - FOCUS ON HEALING - start doing healing practices, even if you feel they are not working - they are helping you pass the time and that means it is working - and it’s helping to rewire you so that when you’re done you will be wired and ready to rebuild your life.

So instead of viewing your nervous system as injured or damaged or permanently altered, focus on its healing capacity, that your DNA is wired for surviving and thriving, that you are in a healing crisis, that it is working REALLY HARD for you right now to repair itself. Shift your focus away from the scary stuff and towards healing and where you are headed. Healing is the outcome. Do not entertain anything else.”

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

On 6/26/2026 at 8:57 AM, Chippy said:

For the minute just surviving is enough

I think this is what a lot of the mindfulness, coping skills etc misses: if you're acutely suffering and it's not just anxiety, it takes everything just to survive.

If that's all you can do, that's all you can do. Try not to beat yourself up for not surviving "well".

Nothing I say is medical advice, it is simply my opinion. I am an anonymous person on an internet forum with no relevant qualifications other than being badly harmed by a drug. For all you know, I could be an idiot. You are making your own decisions and part of that is deciding how much to listen to my opinion, if at all.

 

Perhaps you should consider this post an artistic work of fiction written for entertainment purposes.


Story from SA: LukeUK: Remeron/Mirtazapine Severe Withdrawal - Introductions and updates - Surviving Antidepressants

 

15mg Remeron/Mirtazapine November starting 2022 (severe physical side effects)

Attempted to taper off January 2023, ended up having a major breakdown and going up to 30mg, took weeks to stabilise

1 month taper  to 0mg

Last dose April 2023

Severe withdrawal syndrome with many physical symptoms

Summary: 5 months using Mirtazapine, including 1 month taper ending late April 2023.

Hey, How have you been @Sminismoni ?

Just checking on you.

Hopefully you been better and been learning how to deal with the symptoms better.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 
Feel free to mention me whenever help is needed.

 

Current Supplements: Morning: Aloe Vera Gels. Night: 6mg melatonin and 133mg magnesium glycinate. Taking Omega 3 as needed to calm dyskinesia or over stimulation..

Current Medications: Mirtazapine, Lasea (lavender oil) before bed.

------------------------------------------

Tapering: Mirtazapine 15mg, (went compounded) 13.5mg 08/May/2025, 12.1mg 10/July/2025, 15/July/2025 15mg (half tablet), 26/July/2025 14.35mg (moved to dry cutting method) ), 03/Aug/2025 14.6mg, 24/Nov/2025 14.47mg, 29/Jan/2026 14.35mg

Note: Had a lot of issue with degradation with different cutting times and compounded pharmacy which caused withdrawals and a more sensitive nervous system.

  • Author

Another horrific night. 1 hour of sleep. Skin prickling all over, a churning washing machine feeling inside my body, nausea, confusion, joint pain and all while feeling wide awake like I've taken cocaine.

Tried weighted blanket - Nope

Tried stretching - Nope

Hot pack - No

Cold pack -No

Rocking to and fro - just made me dizzy

Tried some food - more nausea

And it's still going.....

Edited by Sminismoni

November 2024 Elvanse for ADHD. Anxiety and jaw clenching, stopped after 4 weeks. Felt fine.

 

January 2025 Medikinet XL

Made me depressed and suicidal so stopped after 3 weeks. Felt fine

 

March 2025 Concerta XL Made me depressed and suicidal so stopped after 2 weeks. Felt fine

 

April-May 2025 Amfexa and Methylphenidate instant release, both only worked for an hour so stopped.  Felt fine.

 

June 2025 Atomoxetine started slow taper. Immediate hot flushing and feeling sluggish.

 

July-September 2025 Tapered up to 70mg Atomoxetine. Constipation, insomnia, muscle spasms, weird thoughts, mood swings, night sweats, hot flushes, brain fog, dizziness etc

 

October 2025 rapid taper off Atomoxetine. I also had a GA for shoulder surgery the same week I finished meds.

 

Ongoing symptoms ever since, but now also trouble swallowing, difficulty passing urine, muscle twitches, depersonalisation, heavy limbs, emotional blunting, apathy, feeling "wired" and robotic, PGAD.

 

New symptoms February 2026: Nausea and burning head

 

Supplements: B12, folate and Vit D as all were bordering on deficient. 

Bad reactions to CBD oil, Mag glycinate, Mag L.Threonate and Fish Oil

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