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Finni: Sensitized by Many Med changes and Mirtazapine

Featured Replies

  • Author
26 minutes ago, Catbird said:

So sorry this is present for you @Finni . I had a terrible time trying to reduce Mirtazapine. I did a 6 month taper (same story as others - way too fast) as my doctor said it would be fine. I ended in a heap with severe agitation and distress. I was put back on my SSRI which I'm currently tapering now. However it looks like you've been on the same dose for at least 2 months and having severe WD symptoms. I feel for you. I've had a wrenching gut for 8 days now so I empathise. 🤗

Hugs back 🤗

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

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  • NBJ71
    NBJ71

    And please don’t beat yourself up about going to the hospital, you were looking for a solution to help yourself. I did exactly the same thing Finni and so have many others. The hospital made me so muc

  • Fullhealing
    Fullhealing

    I know it feels endless @Finni I'm so sorry, but let me assure you are not permanently damaged, it always amazes me anew what the body can overcome and you are no exception. You've been through a

  • Finni
    Finni

    My affirmation:    “I am healing, and my body is strong enough to get through this. Healing is happening even when I can’t feel it.”

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  • Author

My nervous system is swinging wildly between feeling to activated by mirtazapine one day to feeling like I’ve been cold turkey off of it the next day

Yesterday I was activated by it through the night and throughout the first part of the day I had just had that certain medicated tingly electric feeling, but no big distress until evening.

It did not activate me during the night last night but now I feel an incredibly tight pounding, terrified head super tight muscles everywhere crying overwhelmed with terror surges.

Seems like I can hardly see straight

It would be one thing if I had actually reduced a significant chunk, but I have it except for the one night of the slightly slightly lower dose

It’s more like my nervous system has “crashed” and I don’t know what to do. I truly am afraid I’m not going to make it.

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

@Finni It truly is a terrifying journey and made worse by the fact we don't know one day yo the next what will happen .I can relate to you feeling scared ,I'm fine with my symptoms when they are manageable but when they are not its scary as we feel like we are losing control and we don't know what to do ,I know the feeling well . All we can do is to hold on and have faith that these symptoms will go away....I.hope they do for you, you will make it just like all the other times ❤️

2016 - 2019 Sertraline 25mg highest dose 100mg 

2019 C Ted 25mg Bad withdrawals 

01/2020 reinstated 25mg 

06/2020 - 12/2021 tapered from 100mg to 6mg jumped off .bad withdrawals like before .

06/2022 reinstated 25mg 

10/2023 started taper of 25mg not sure of starting drops 

04/2025 5mg

06/2025 4.1mg

08/2025 3.5mg 

10/2025 3.1 mg

12/2025 2.5mg

01/2026 to present 2.27mg 

 

 

3 hours ago, Finni said:

My nervous system is swinging wildly between feeling to activated by mirtazapine one day to feeling like I’ve been cold turkey off of it the next day

Yesterday I was activated by it through the night and throughout the first part of the day I had just had that certain medicated tingly electric feeling, but no big distress until evening.

It did not activate me during the night last night but now I feel an incredibly tight pounding, terrified head super tight muscles everywhere crying overwhelmed with terror surges.

Seems like I can hardly see straight

It would be one thing if I had actually reduced a significant chunk, but I have it except for the one night of the slightly slightly lower dose

It’s more like my nervous system has “crashed” and I don’t know what to do. I truly am afraid I’m not going to make it.

Oh @Finni I feel you strongly, our amazing system is fighting fiercely with angry chemicals, this is the ugly expression but it has an end, I try to hold on to it and give the due respect although it is so difficult amidst the suffering.

Praying for significant and long-lasting relief for you so very soon.

Big comforting hug 🩷

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 20% 0.0358g (2mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of anxiety and sleep that seems to continue to improve.

  • Author

Wow

I’m back to wondering if I’m having adverse reactions. Such strong responses after about an hour and a half after taking mirtazapine and then I wake up and as the morning goes on, I feel like I’ve been given several shots of adrenaline. Overwhelming pressure and pounding and shaking.

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

@Finni sorry to hear that it's not nice ..I woke up at 3.00 like that and it's just eased off ! There could be something going on there especially with the timing

2016 - 2019 Sertraline 25mg highest dose 100mg 

2019 C Ted 25mg Bad withdrawals 

01/2020 reinstated 25mg 

06/2020 - 12/2021 tapered from 100mg to 6mg jumped off .bad withdrawals like before .

06/2022 reinstated 25mg 

10/2023 started taper of 25mg not sure of starting drops 

04/2025 5mg

06/2025 4.1mg

08/2025 3.5mg 

10/2025 3.1 mg

12/2025 2.5mg

01/2026 to present 2.27mg 

 

 

Sorry to hear you’re still struggling @Finni 🤗

Link to SA Profile: https://www.survivingantidepressants.org/forums/topic/32414-catbird-introduction-a-long-and-winding-road/

1996 Commenced on Sertraline 50 - 100mg. Many ADs trialled -Fluoxetine 20 mg, Paroxetine 20mg, Venlafaxine 75mg, Escitalopram 10 - 20mg, Vortioxetine 20mg, Bupropion 150mg.  2019 Recommenced Escitalopram 2022 Mirtazapine 30mg - Rapid taper. Amitriptyline 20mg

CURRENT MEDICATIONS: Escitalopram taper from ~ 10mg commenced 2024, Amitriptyline 20mg at night, Diazepam 7.5mg total per day, Baclofen 10mg morning, 10mg lunch and 20mg night, Polaramine 2mg at night, Ketamine troche 25mg per day (Ceased early September 2025), Valsartan 160mg evening, HRT (Oestrogen 25mcg/day) 

ESCITALOPRAM TAPER: 5 April 2025 - started holding at 1.516mg. Escitalopram taper resumed July 2025; End Aug 1.364; End Sept 1.228; End Oct 1.145; End Nov 1.1 Early Dec 1.11; End Dec 1.082; 2026 End Jan 1.047; Feb 6 1.030; Feb 20 1.014; April 10 1.012; May 3 1.014;

Supplements: Mg++ glycinate, Omega 3s, Curcumin. Vit D3/K2 spray, Vitamin B12 spray, chelated zinc.

So sorry @Finni hang in there, better moments will come xxx

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 20% 0.0358g (2mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of anxiety and sleep that seems to continue to improve.

Hang in there brave @Finni 🛡️⚔️

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

I feel like I’m stuck in a pattern of taking Mirtazapine, having reactions throughout the night and then things building through the morning until they peak midday and then slowly gradually feeling better by evening, and then it starts all over again.

Last night after mirtazapine, I had the familiar feeling of heat and weird electricity…

By midnight, I was in full on horrible pressure in my whole body and head.

Now at 4:45 AM, the pressure and deep electricity, heat and terror is crushing.

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

1 hour ago, Finni said:

I feel like I’m stuck in a pattern of taking Mirtazapine, having reactions throughout the night and then things building through the morning until they peak midday and then slowly gradually feeling better by evening, and then it starts all over again.

Last night after mirtazapine, I had the familiar feeling of heat and weird electricity…

By midnight, I was in full on horrible pressure in my whole body and head.

Now at 4:45 AM, the pressure and deep electricity, heat and terror is crushing.

Sorry you are having to endure such terrible WD symptoms @Finni 💕

Link to SA Profile: https://www.survivingantidepressants.org/forums/topic/32414-catbird-introduction-a-long-and-winding-road/

1996 Commenced on Sertraline 50 - 100mg. Many ADs trialled -Fluoxetine 20 mg, Paroxetine 20mg, Venlafaxine 75mg, Escitalopram 10 - 20mg, Vortioxetine 20mg, Bupropion 150mg.  2019 Recommenced Escitalopram 2022 Mirtazapine 30mg - Rapid taper. Amitriptyline 20mg

CURRENT MEDICATIONS: Escitalopram taper from ~ 10mg commenced 2024, Amitriptyline 20mg at night, Diazepam 7.5mg total per day, Baclofen 10mg morning, 10mg lunch and 20mg night, Polaramine 2mg at night, Ketamine troche 25mg per day (Ceased early September 2025), Valsartan 160mg evening, HRT (Oestrogen 25mcg/day) 

ESCITALOPRAM TAPER: 5 April 2025 - started holding at 1.516mg. Escitalopram taper resumed July 2025; End Aug 1.364; End Sept 1.228; End Oct 1.145; End Nov 1.1 Early Dec 1.11; End Dec 1.082; 2026 End Jan 1.047; Feb 6 1.030; Feb 20 1.014; April 10 1.012; May 3 1.014;

Supplements: Mg++ glycinate, Omega 3s, Curcumin. Vit D3/K2 spray, Vitamin B12 spray, chelated zinc.

1 hour ago, Finni said:

I feel like I’m stuck in a pattern of taking Mirtazapine, having reactions throughout the night and then things building through the morning until they peak midday and then slowly gradually feeling better by evening, and then it starts all over again.

Last night after mirtazapine, I had the familiar feeling of heat and weird electricity…

By midnight, I was in full on horrible pressure in my whole body and head.

Now at 4:45 AM, the pressure and deep electricity, heat and terror is crushing.

My heart goes out to you @Finni sending much healing your way xxx

1998 forced on cipramil *no anxiety/depression background*

Over the years all kinds of SSRI/SNRI/antipsychotics/stabilizers due to apparently side effects/withdrawal

Many attempts to quit over the years with failure (extremely rapid taper followed by doctors' guidens)

Current attempt-Paxil 20 mg:

6/24 20 mg to 5 mg-severe AKA

9/24 Increase to 20-AKA continues

10/24 stopped completely-AKA out of control 

11/24 Zoloft bridge attempt-25 mg to 75 mg+Seroquel-AKA continued-stopped them CT.

12/24 Back on Paxil 10mg (0.1789g)-some stabilization-from here tapered by about 30% each time (don't remember doses and dates).

2025 - 7.10 0.0558g (3.11mg)/7.11 3% 0.0541g (3.02mg)/4.12 1% 0.0535g (2.98mg)

2026 - 3.1 1.5% 0.0526g (2.93mg)/9.1 8.5% 0.0480g (2.68mg)/16.2 1.8% 0.0470g (2.62mg)/21.3 1% 0.466 (2.60mg)/23.4 2.2% 0.455g (2.54mg)/8.7 20% 0.0358g (2mg)

Supplements:

Magnesium Glycinate - started 28.5.26 1 capsule 200mg in the morning - Increased brain fog and muscle stiffness - stopped after two weeks.

Iron - liquid, quarter of recommended dose - increased anxiety and burning sensation - stopped after two weeks.

Saffron - started 8.7.26 1 capsule 30mg in the morning - pretty immediate improvement in terms of anxiety and sleep that seems to continue to improve.

  • Author

I’m in a horrible quandary again.

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

@Finni what sort of quandary?....I'm with you today as not having a great day hopelessness and thinking I'm going to be stuck like this !!

2016 - 2019 Sertraline 25mg highest dose 100mg 

2019 C Ted 25mg Bad withdrawals 

01/2020 reinstated 25mg 

06/2020 - 12/2021 tapered from 100mg to 6mg jumped off .bad withdrawals like before .

06/2022 reinstated 25mg 

10/2023 started taper of 25mg not sure of starting drops 

04/2025 5mg

06/2025 4.1mg

08/2025 3.5mg 

10/2025 3.1 mg

12/2025 2.5mg

01/2026 to present 2.27mg 

 

 

  • Author
4 minutes ago, Beehive said:

@Finni what sort of quandary?....I'm with you today as not having a great day hopelessness and thinking I'm going to be stuck like this !!

Ive become even more reactive to mirtazapine and it seems like it might even be paradoxical… So I would love to reduce again, but then afraid when I do, I feel like I might get even worse.

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

@Finni I feel your pain it definitely is a quandary ,I suppose ultimately the decision rests with you people can guide you but whose to say what's right or wrong when it comes to these tablets. I'm really sorry your in this position 😔 I wish I could help but I would feel the same as you

2016 - 2019 Sertraline 25mg highest dose 100mg 

2019 C Ted 25mg Bad withdrawals 

01/2020 reinstated 25mg 

06/2020 - 12/2021 tapered from 100mg to 6mg jumped off .bad withdrawals like before .

06/2022 reinstated 25mg 

10/2023 started taper of 25mg not sure of starting drops 

04/2025 5mg

06/2025 4.1mg

08/2025 3.5mg 

10/2025 3.1 mg

12/2025 2.5mg

01/2026 to present 2.27mg 

 

 

  • Author
6 minutes ago, Beehive said:

@Finni I feel your pain it definitely is a quandary ,I suppose ultimately the decision rests with you people can guide you but whose to say what's right or wrong when it comes to these tablets. I'm really sorry your in this position 😔 I wish I could help but I would feel the same as you

Are you trying to decide whether to hold or keep tapering?

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

@Finni Yes I am especially when I'm in a bad place my thoughts get very catastrophising amd hopeless like today but when I'm.good I don't think about it ! I think you are in a different position to me as your symptoms are more regular and after your dose

2016 - 2019 Sertraline 25mg highest dose 100mg 

2019 C Ted 25mg Bad withdrawals 

01/2020 reinstated 25mg 

06/2020 - 12/2021 tapered from 100mg to 6mg jumped off .bad withdrawals like before .

06/2022 reinstated 25mg 

10/2023 started taper of 25mg not sure of starting drops 

04/2025 5mg

06/2025 4.1mg

08/2025 3.5mg 

10/2025 3.1 mg

12/2025 2.5mg

01/2026 to present 2.27mg 

 

 

  • Author
11 minutes ago, Beehive said:

@Finni Yes I am especially when I'm in a bad place my thoughts get very catastrophising amd hopeless like today but when I'm.good I don't think about it ! I think you are in a different position to me as your symptoms are more regular and after your dose

It sounds like you are very functional for the most part 🤗 💗

It probably makes waves feel even worse because you can feel so normal other times

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

Absolutely!! It's awful to feel normal and have it taken away from you ! ...I hope you can decide soon what you want to do I think once you have made a decision it may help

2016 - 2019 Sertraline 25mg highest dose 100mg 

2019 C Ted 25mg Bad withdrawals 

01/2020 reinstated 25mg 

06/2020 - 12/2021 tapered from 100mg to 6mg jumped off .bad withdrawals like before .

06/2022 reinstated 25mg 

10/2023 started taper of 25mg not sure of starting drops 

04/2025 5mg

06/2025 4.1mg

08/2025 3.5mg 

10/2025 3.1 mg

12/2025 2.5mg

01/2026 to present 2.27mg 

 

 

  • Author

I’m terrified to try to reduce again, even though my instinct is telling me that mirt is way too much for my nervous system

This morning, I have such deep electricity in my back body and head and rotary motor type sensations in my head after waking up several times in the middle of the night, feeling very nervous, deeply nervous and activated. Yesterday was another day of huge vestibular symptoms and deep electric sensations and distress/panic/ crying.

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

5 minutes ago, Finni said:

I’m terrified to try to reduce again, even though my instinct is telling me that mirt is way too much for my nervous system

This morning, I have such deep electricity in my back body and head and rotary motor type sensations in my head after waking up several times in the middle of the night, feeling very nervous, deeply nervous and activated. Yesterday was another day of huge vestibular symptoms and deep electric sensations and distress/panic/ crying.

I’m sorry to read @Finni only you know the right path. I wish we could tell you what you should do.

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

@Chippy

I wonder if it’s worth it for me to try to split my dose.

Dr. Horowitz suggested taking 3 mg earlier and earlier until I get to 12 hours apart. At least that was one option.

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

5 minutes ago, Finni said:

@Chippy

I wonder if it’s worth it for me to try to split my dose.

Dr. Horowitz suggested taking 3 mg earlier and earlier until I get to 12 hours apart. At least that was one option.

I don’t see why you shouldn’t at least try it and see if it helps @Finni

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

This is terrifying

The pressure in my head was so intense yesterday that it hurt to even touch my scalp.

Felt like I had an accelerating motor in my body last night after taking mirtazapine. I woke up around midnight or 1 AM in full throttle. Dozed a little bit after that on and off.

Now as the sun is rising my whole body is pressurized. My head is pressurized. I feel like everything is pounding and have the twisting nausea and terror.

Electrical feelings in my stomach, solar plexus, tailbone. Clamping muscles in stomach and back and neck.

I’m in disbelief that I’ve gotten this much worse.

Edited by Finni

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

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