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Skamen: Anhedonia caused by 14 years of Paxil, now in hell after CT

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  • Author

Dear @namastejen1, thank you for asking. Yes, I have dropped from .3 mg to .27 mg since 10 days now. My sleep is still broken by the hellish adrenaline rushes, and the morning I am in awful dread. Anhedonia, depression, hopelessness, fatigue... don't quit me. But the drop didn't worsen my 12 month hell, I am in the same terror. 

I was asking me how you are able to function with more Mirtazapine than me (.4/.27)? Do you feel good? Is it the CT for me which does my state unbearable? Is it the iatrogenic anhedonia which threw me in this Inhumane state? Indeed, my profound wish is to eliminate Mirtazapine from my brain. I hate this poison.

Sbetla

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

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  • LostinCanada
    LostinCanada

    I've read about people being in such a mess and then one day just waking up normal.... never give up Hope...it sustains is...we don't know what tomorrow will bring.  I have also read twice about

  • Yes @skamen THAT'S what I want to see (YOU HAVE HOPE) as hard as it is Svetla YOU WILL beat this, YOU have the STRENGTH and RESILIANCE to see this through and get your life BACK. Stronger than be

  • poulette38
    poulette38

    Oh, I pray for each of you from this forum every evening. 🙏🩷 Let us all stay in Christ.  And you know what, I had this thought. Why did it happen to us? Well guys, I think we are among human be

Posted Images

Hi Svetla, stay strong and stay safe.

take care,      B.🙏🙏🤞🌷

2001-2021 Prozac 20mg

2020-2021 Tramadol 300mg

2022 April 15th  Started Mirtazapine 15mg

2022 Sept 15 dropped to 7.5mg

2023 May 16th failed CT reinstated.

2023  June 30th tapering off

2025 Jan 7th Stopped all drugs.

  • Author

Thank you, @NT1100B, for your encouragement. It is so hard to keep going being in such a Hell. The adrenaline rushes torture me all the he night, I wake up in chemical terror, in hellish doom, it is a real agony. What a mess, I hate Mirtazapine, I hate the psychiatry, how is it possible to prescribe such a poison to the patients? 

At least, I hope you are doing well, B.

Svetla

Edited by skamen

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

Just dropping by to say you are not alone ❤️‍🩹

SA Thread: https://www.survivingantidepressants.org/forums/topic/33406-nemina-tapering-escitalopram/


AR Thread: https://antidepressantrecovery.org/topic/14-nemina-tapering-escilatopram-and-zolpidem/

 

Drug History

2013 - 2025:  Zolpidem 5 mg

2015 - Oct 2024: Venlafaxine, Sertralin (Zoloft), Paroxetin (Paxil),duloxtin (cymbalta), Citalopram (Celexa), Escitalopram (Lexapro) and more 

 

Current Drugs

L-Thyroxin 75, Estrogen, Progesteron 200

 

Tapering Escitalopram

Sept 2024: Setralin/zoloft 75 mg

Oct 2024: Switch to Escitalopram / Lexapro 2mg

Then I tapered over a year from 2mg to 0,32 mg (October 2025).  108 days hold without stabilizing. Resumed taper February 2026:

11 Feb 2026 0.314mg 

18 Feb 2026 0.307mg 

21 Feb 2026 0.302mg

09 Mar 2026 0.297mg

18 April 2026 0,293 mg

18 May 2026 0,285 mg

 

Tapering Zolpidem: From 5 mg to 0,7 mg in 12 months,  then just crumbs for several weeks, now 0! (Jan 2025)

 

Other Supplements 

Omega 3, Magnesium Glycinate, Vit D, Calcium, L-theanin.

  • Author

Thank you, @Nemina, for your presence. My living Hell is endless.

Svetla

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

@skamen Svetla Im sorry ive not posted recently. You are such a warrior and your resolve impresses me so much. I think about you every day and always hope things are improving. Which they will eventually. Chippy xxx

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

  • Author

Thank you, @Chippy, for your presence. The living Hell continues, cortisol spikes, morning terror, hopeless, awful anhedonia... I don't know if this agony has an end... But I don't have a choice, I have to believe in the Time.

Svetla

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

@skamen

You’re going to get there! ❤️❤️

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

  • Author

Thank you, @Finni, we have to stay strong, there is not another option.

Svetla

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

19 minutes ago, Finni said:

@skamen

You’re going to get there! ❤️❤️

You will @skamen

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

Just thinking of you @skamen

 

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

Hi @skamen

How are you ? Do you still feel anhedonia, or it's better sometimes? 

 

A little advice that seems very simple but I haven’t seen reflected in your messages (and you told me you were in your home frequently): do you exercise? I mean, daily walking under the sun, for example? It helps a lot, I promise you. With all my prayers.

About 1 week of st John's wort

 

 

then

 

20-25 october 2025 : escitalopram 10mg (liquid)

 

 

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

 

Stop everything on 9th december 2025 (last dose 2mg 9th december).

 

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

 

"The devil is a liar and he's smiling." 😈

 

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle.

 

Svelta, you will write a success story one day and we will be all here 🙂. Remember that. 🤗

Edited by poulette38

About 1 week of st John's wort

 

 

then

 

20-25 october 2025 : escitalopram 10mg (liquid)

 

 

18 november- 9 december 2025 : Fluoxétine 20 mg (liquid, 10 ml) - 2 days at 30 mg then return to 20 mg because of side effects.

 

Stop everything on 9th december 2025 (last dose 2mg 9th december).

 

in parallel prazepam drops (3 to 13 drops at the evening), on november 2025.

 

"The devil is a liar and he's smiling." 😈

 

🌸"The flower that blossoms in adversity is the most beautiful and rare of all." 🌸

"Do not take life quite so seriously – you surely will never get out of it alive". Bernard Le Bovier de Fontenelle.

 

  • Author

Dear @poulette38 and @Finni, thank you for stopping by me. I am not good, hellish anhedonia, insomnia, inner akatisia, terrible anxiety... Hell on Earth. This suffering cannot be put into words. But I don't have a choice, I need hold on like all of us.

Svetla 

Edited by skamen

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

🫂 

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

@skamen

 

you got this your so strong keep fighting 

 

👊🙏❤️

Mirtazapine for 3 weeks august 2025 15mg made me numb didn’t know why took an overdose of 10x 15mg tablets.

 

reinstated at 11 weeks due to symptoms and inpatient stay. 

currently on 3.75mg mirtazapine

 

symptoms/ anhedonia, slightly blurred vision, tinnitus, toxic naps 

depression, anxiety, pins and needles 

  • Author

Dear @Richie, thank you, it means a lot. 

I am so happy for you, I read all your posts.

Svetla

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

Hi @skamen hang in there. Please don’t forget how strong you are ❤️

12 august 2025; 5mg fluoxetine 

30 August 2025: 10mg fluoxetine 

11 september 2025: 5mg fluoxetine 

19 september 2025; 2.5mg fluoxetine 

2 oktober 2025: 0mg

 

I had to cut my pills in half and quarters, so and don’t think I had accurate dosages.

  • Author

Dear @Sophia, I really need this encouragement to be able to stay alive. Thank you,

Svetla

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

2 hours ago, skamen said:

Dear @Sophia, I really need this encouragement to be able to stay alive. Thank you,

Svetla

You are going to have such an inspirational story to tell when you’re through this! 

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

8 hours ago, poulette38 said:

Svelta, you will write a success story one day and we will be all here 🙂. Remember that. 🤗

100% 🙂

I’m not a medical professional and cannot offer medical advice. I only offer my thoughts as support. Please speak to your health practitioner about your care. This is a peer site where we support each other on our taper/recovery journeys. 

 

If you are from the UK please make sure you fill in a 'Yellow Card' report for the MHRA. It is you doing your bit to help make a difference.

Please take the time to do it today 🙂 https://yellowcard.mhra.gov.uk

For US members details here.

@skamen

not that it really matters I’m just wondering if it was the mirtazapine that brought on more of the adrenaline rushes and cortisol surges? 

I’ve never experienced anything like it until my Mirtazapine dose changed…

 

Or is this just common in antidepressant withdrawal?

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

  • Author

Hi @Finni, the adrenaline rushes are linked to the PWD. The are my most horrible symptom, all the he night with hot flashes + hellish depression. 

Svetla 

2011-2023 Paxil

2023-2024 Effexor

Since February 2024 in anhedonia caused by the long use of AD

February 2024-March 2025 drug after drug after drug... 70 rTMS sessions, 8 ketamin infusions-nothing worked

March 2025 CT upon doctor "advice" from Desipramine, Viibryd, Lithium at high doses all together in 6 days

Since then awful withdrawal: unbearable anxiety, panic attacks, adrenaline rushes, hot flashes, muscle pain over all the body, insomnia, depression, intrusive thoughts, brain fog

Current tapering Mirtazapine : December 29,2025-3 mg, February,15, 2025-2,7 mg, February,28-2,5 mg, March,8-2 mg, March,14-1,5 mg, March,20-0 mg

Thinking of you 💜💪🏻💜

For US members: Please report med to FDA Med Watch

2017 (May) - Ativan .5 mg (3 x Daily) 

2018 (Feb) - Mirtazapine 7.5 mg 

2018 (May) - Ativan to Valium - Switch - Can’t Remember how long it took -tapered to 3 mg of Valium

2024 (May) - Valium Tolerance

2024 (2 Nov) - Completed taper off Valium 

2024 (2 Nov) - Mirtazapine increased to 15 mg

2025 (Feb) - Ativan 0.25 mg (3 x Daily) - Became Paradoxical - Started weaning got to 0.11mg

2025 (Mar) - Ativan 0mg - CT In detox

2025 (April) Started Depakote 1500mg - In detox

2025 (April) - Depakote 500mg (2 x Daily) once home

2025 (Aug) - Completed taper off Depakote

2025 (Aug) - Akathisia surges throughout the day with calming in between

2025 (Sept) - Gabapentin (Micro Dose) - Was calming at first and then became paradoxical so stop

2025 (Oct) - Depakote - RI – (Two days of small dose) Became scared and stopped with WD & aka

2025 (Oct) - Seroquel 50 mg XR – 1 Week - more and more activating and increased aka

2025 (Oct) - Psychiatrist told me to stop it. But I took a few days of a smaller dose of IR then stopped - Not activating

2025 (Nov) - Hydroxyzine 2.5mg - it was paradoxical so stopped

2025 (1 Dec) - Mirtazapine 22.5mg - (2 Days) Was incredibly overstimulating started reducing to previous

2025 (3 Dec) - Mirtazapine 18.75mg

2025 (10 Dec) - Mirtazapine 16.87mg

2025 (22 Dec) - Mirtazapine 15mg

2026 (23Jan) - Mirtazapine 14.7mg

2026 (23 Jan) - Mirtazapine 1mg Panic dose

2026 (24 Jan) - Mirtazapine 15mg

2026 (25 Feb) – Mirtazapine 14.7mg (-2%)

2026 (18 Mar) - propranolol 2.5 mg one time

2026 (21 Mar)- Mirtazapine- 15 mg accidentally in sleepy state

2026 (22 Mar) - Mirtazapine 14.79 mg (more accurate scales) 

2026 (29 April) Mirtazapine 14.7 mg (on suggestion of Horowitz) immediate intense symptoms

2026 (30 April) Mirtazapine 14.79 mg

2026 (23 May) propranolol 2.5 mg one time

2026 (01 June) Mirtazapine 14.79 mg dose was 5 hours late

 

 

On 2/24/2026 at 1:06 PM, skamen said:

Dear @namastejen1, thank you for asking. Yes, I have dropped from .3 mg to .27 mg since 10 days now. My sleep is still broken by the hellish adrenaline rushes, and the morning I am in awful dread. Anhedonia, depression, hopelessness, fatigue... don't quit me. But the drop didn't worsen my 12 month hell, I am in the same terror. 

I was asking me how you are able to function with more Mirtazapine than me (.4/.27)? Do you feel good? Is it the CT for me which does my state unbearable? Is it the iatrogenic anhedonia which threw me in this Inhumane state? Indeed, my profound wish is to eliminate Mirtazapine from my brain. I hate this poison.

Sbetla

Sorry to be away for a time again...but we got sick here at the end of the week and still not 100% today. I try to get on and post a few replies when I can with my work and kiddo schedules. I am so sorry that this is such a rough road for you. I think it is all the other CTs that are causing problems. They probably run on different receptors too. So it's like all of them need to aggressively heal at the same time you are tapering Mirt, which s#cks. I pray that they heal in due time and you start to feel some relief.

I wonder if you can channel your fighting spirit against all of this into activism or helping others...actually I know you can, we all can. It's a warrior's spirit! Blessings my friend!

2 Tim 1:7 For God did not give us a spirit of cowardice (fear); but rather of power and love and self-control (a sound mind).

The Whole Story About Me

--Current Rx: since 2000-2025 Levothyroxine discontinued late Sept 2025 under DO supervision--no menstrual cycle for 2 months, Hypothalamus PMG brought it back and has been regular ever since under functional chiropractor =o) thank God for holistic medicine

2017-current Remeron/Mirt. recent taper schedule here: crushed pills 0.45mg May 30, 2025; 0.4mg Sept 14, 2025; found out 0.4mg weighed is actually a dose of 0.44mg Dec 19, 2025 and now using compounded Rx; 0.41mg Feb 27, 2026; 0.39mg April 3, 2026, 0.38mg May 8, 2026, 0.37mg June 28, 2026.

--Supplements: Standard Process-Whole Food Folate, Prolamine Iodine Plus, B Vitality w/ CoQ10, Zypan, RNA, Cataplex E, Symplex F, and Immuplex (sort of like a multi but for Oct-Apr) when needed; Biotics Research- Mg-Zyme 100mg; Omega-3 Oil, Black Currant Seed Oil, Vitamin D3/K2 drops; sometimes Seeking Health methyl free multi vitamin and elderberry zinc gummies

**Love my work, fitness, polyvagal exercises (includes yoga-style poses for nervous system regulation), prayer/Inner Healing Prayer, holistic health, somatic therapies, lovingkindness, forest therapy, singing, helping others, spending time in nature and with family and friends.

Anti-histamine Withdrawal Video-Explains a lot (This is not me.)

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